2006
Transcription Factor NF‐κ B: Function, Structure, Regulation, Pathways, and Applications
Cheong R, Levchenko A. Transcription Factor NF‐κ B: Function, Structure, Regulation, Pathways, and Applications. 2006 DOI: 10.1002/3527600906.mcb.200500006.Peer-Reviewed Original ResearchTranscription factor subunitNF-κBTranscription factor NFPosttranslation modificationsSignal transductionTranscription factorsFactor subunitTarget genesCombinatorial specificityRel familyStress responseGreat therapeutic interestFactor NFIκB kinaseNF-κB activityMost cellsNumerous mechanismsSubunitsCentral roleTherapeutic interestInhibitorsTransductionKinaseGenesCytoplasm
2004
The Systems Biology of Glycosylation
Murrell M, Yarema K, Levchenko A. The Systems Biology of Glycosylation. ChemBioChem 2004, 5: 1334-1347. PMID: 15457533, DOI: 10.1002/cbic.200400143.Peer-Reviewed Original ResearchConceptsSystems biologyRegulation of differentiationRegulation of glycosylationEukaryotic cellsBiochemical systems analysisCell regulation processesCell decisionsSignal transductionGlycosylationBiologyRegulation processesRegulationTransductionApoptosisDifferentiationProfound influenceCellsNovel research methodology
2000
Scaffold proteins may biphasically affect the levels of mitogen-activated protein kinase signaling and reduce its threshold properties
Levchenko A, Bruck J, Sternberg P. Scaffold proteins may biphasically affect the levels of mitogen-activated protein kinase signaling and reduce its threshold properties. Proceedings Of The National Academy Of Sciences Of The United States Of America 2000, 97: 5818-5823. PMID: 10823939, PMCID: PMC18517, DOI: 10.1073/pnas.97.11.5818.Peer-Reviewed Original ResearchConceptsMitogen-activated protein kinaseScaffold proteinProtein kinaseSpecific cellular contextDifferent subcellular compartmentsDetailed biochemical modelCellular contextSignal transductionSubcellular compartmentsScaffold concentrationsScaffold levelMultimolecular complexesFull activationGeneric scaffoldKinaseProteinBiochemical modelPathwaySignal propagationTransductionComplexesQuantitative computer modelCrosstalkCompartmentsActivation