2018
Engineering tyrosine residues into hemoglobin enhances heme reduction, decreases oxidative stress and increases vascular retention of a hemoglobin based blood substitute
Cooper C, Silkstone G, Simons M, Rajagopal B, Syrett N, Shaik T, Gretton S, Welbourn E, Bülow L, Eriksson N, Ronda L, Mozzarelli A, Eke A, Mathe D, Reeder B. Engineering tyrosine residues into hemoglobin enhances heme reduction, decreases oxidative stress and increases vascular retention of a hemoglobin based blood substitute. Free Radical Biology And Medicine 2018, 134: 106-118. PMID: 30594736, PMCID: PMC6597946, DOI: 10.1016/j.freeradbiomed.2018.12.030.Peer-Reviewed Original ResearchConceptsTyrosine residuesΒ-subunitSingle tyrosine mutationsFerryl heme speciesOxidative stressExtracellular proteinsTyrosine mutationWild typePromising mutantsHEK cellsProtein surfaceHeme speciesMutationsMembrane damageRedox-active tyrosine residueHeme reductionOxidative toxicityFerryl speciesFerric HbSubunitsHb additionHeme lossSpeciesProteinFerric form
2008
Towards a novel haemoglobin-based oxygen carrier: Euro-PEG-Hb, physico-chemical properties, vasoactivity and renal filtration
Portörő I, Kocsis L, Hermán P, Caccia D, Perrella M, Ronda L, Bruno S, Bettati S, Micalella C, Mozzarelli A, Varga A, Vas M, Lowe K, Eke A. Towards a novel haemoglobin-based oxygen carrier: Euro-PEG-Hb, physico-chemical properties, vasoactivity and renal filtration. Biochimica Et Biophysica Acta 2008, 1784: 1402-1409. PMID: 18405674, DOI: 10.1016/j.bbapap.2008.03.005.Peer-Reviewed Original Research
2006
Fractal and Noisy CBV Dynamics in Humans: Influence of Age and Gender
Eke A, Hermán P, Hajnal M. Fractal and Noisy CBV Dynamics in Humans: Influence of Age and Gender. Cerebrovascular And Brain Metabolism Reviews 2006, 26: 891-898. PMID: 16292253, DOI: 10.1038/sj.jcbfm.9600243.Peer-Reviewed Original ResearchThe modified Beer–Lambert law revisited
Kocsis L, Herman P, Eke A. The modified Beer–Lambert law revisited. Physics In Medicine And Biology 2006, 51: n91-n98. PMID: 16481677, DOI: 10.1088/0031-9155/51/5/n02.Peer-Reviewed Original ResearchMathematical model for the estimation of hemodynamic and oxygenation variables by tissue spectroscopy
Kocsis L, Herman P, Eke A. Mathematical model for the estimation of hemodynamic and oxygenation variables by tissue spectroscopy. Journal Of Theoretical Biology 2006, 241: 262-275. PMID: 16413035, DOI: 10.1016/j.jtbi.2005.11.033.Peer-Reviewed Original Research
1999
Fractal Analysis of Spontaneous Fluctuations in Human Cerebral Hemoglobin Content and its Oxygenation Level Recorded by NIRS
Eke A, Hermán P. Fractal Analysis of Spontaneous Fluctuations in Human Cerebral Hemoglobin Content and its Oxygenation Level Recorded by NIRS. Advances In Experimental Medicine And Biology 1999, 471: 49-55. PMID: 10659131, DOI: 10.1007/978-1-4615-4717-4_7.Peer-Reviewed Original ResearchConceptsBrain cortex