Model-based evaluation of the microhemodynamic effects of PEGylated HBOC molecules in the rat brain cortex: a laser speckle imaging study.
Portörő I, Mukli P, Kocsis L, Hermán P, Caccia D, Perrella M, Mozzarelli A, Ronda L, Mathe D, Eke A. Model-based evaluation of the microhemodynamic effects of PEGylated HBOC molecules in the rat brain cortex: a laser speckle imaging study. Biomedical Optics Express 2020, 11: 4150-4175. PMID: 32923034, PMCID: PMC7449705, DOI: 10.1364/boe.388089.Peer-Reviewed Original ResearchHemoglobin-based oxygen carriersLaser speckle contrastSpeckle contrastSpatial dispersionAdverse effectsEuro-pegInfrared ImagingRed blood cell velocityRat brain cortexBlood cell velocityPotential adverse effectsNitric oxide scavengingVascular resistanceAdverse eventsBrain microcirculationBrain cortexFractional changeTissue hematocritPlatelet aggregationImaging studiesCell velocityClinical applicationSignificant differencesExtravasationDispersion