2019
One-year changes in brain microstructure differentiate preclinical Huntington's disease stages
Pflanz C, Charquero-Ballester M, Majid D, Winkler A, Vallée E, Aron A, Jenkinson M, Douaud G. One-year changes in brain microstructure differentiate preclinical Huntington's disease stages. NeuroImage Clinical 2019, 25: 102099. PMID: 31865023, PMCID: PMC6931230, DOI: 10.1016/j.nicl.2019.102099.Peer-Reviewed Original ResearchMeSH KeywordsAdultBasal GangliaCorpus CallosumDiffusion Tensor ImagingFemaleHumansHuntington DiseaseLongitudinal StudiesMaleMiddle AgedProdromal SymptomsConceptsOnset of symptomsPreclinical stageDisease stageMean diffusivityHuntington's diseaseGender-matched healthy controlsOnly clinical measurePosterior basal gangliaDistinct pathophysiological mechanismsOptimal therapeutic windowOne-year changeSignificant differencesPreclinical Huntington's diseasePresymptomatic Huntington's diseaseNeurodegenerative phaseNeuroinflammatory processesMotor scoresPathophysiological mechanismsBasal gangliaDisease progressionHealthy controlsHuntington's disease stagesCorpus callosumTreatment responseClinical measuresCombining fMRI during resting state and an attention bias task in children
Harrewijn A, Abend R, Linke J, Brotman M, Fox N, Leibenluft E, Winkler A, Pine D. Combining fMRI during resting state and an attention bias task in children. NeuroImage 2019, 205: 116301. PMID: 31639510, PMCID: PMC6911838, DOI: 10.1016/j.neuroimage.2019.116301.Peer-Reviewed Original ResearchConceptsDot-probe taskAttention bias taskFunctional connectivityThreat biasBias taskCognitive tasksDifferent attentional processesReconfiguration efficiencyTask-based fMRI dataAttentional processesAttention taskSocial reticenceTask performanceAttention stateAnxiety symptomsFMRI dataPattern of modulationPrior researchTaskIQFMRICurrent studyChildrenFunctional hierarchyNetwork changes
2015
Striatal activity and reduced white matter increase frontal activity in youths with family histories of alcohol and other substance‐use disorders performing a go/no‐go task
Acheson A, Tagamets M, Winkler A, Rowland L, Mathias C, Wright S, Hong L, Kochunov P, Dougherty D. Striatal activity and reduced white matter increase frontal activity in youths with family histories of alcohol and other substance‐use disorders performing a go/no‐go task. Brain And Behavior 2015, 5: e00352. PMID: 26221573, PMCID: PMC4511289, DOI: 10.1002/brb3.352.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAspartic AcidBrain MappingChildCorpus StriatumExecutive FunctionFamilyFemaleGenetic Predisposition to DiseaseHumansInhibition, PsychologicalLongitudinal StudiesMagnetic Resonance ImagingMaleMotor CortexNeural PathwaysProton Magnetic Resonance SpectroscopyPsychomotor PerformanceSignal Processing, Computer-AssistedSubstance-Related DisordersWhite MatterConceptsSupplementary motor areaSubstance use disordersWhite matter integrityFamily historyFrontal white matter integrityStriatal activityDorsal striatumFrontal cortical activityCortical activitySMA activityFrontal cortical projectionsDrug use disordersDorsal striatal activitySuch family historyDorsal striatum activityCortical projectionsMotor areaElevated riskOngoing longitudinal studyUse disordersWhite matterDownstream projectionsGo/