2022
Serotonin regulation of behavior via large-scale neuromodulation of serotonin receptor networks
Salvan P, Fonseca M, Winkler A, Beauchamp A, Lerch J, Johansen-Berg H. Serotonin regulation of behavior via large-scale neuromodulation of serotonin receptor networks. Nature Neuroscience 2022, 26: 53-63. PMID: 36522497, PMCID: PMC9829536, DOI: 10.1038/s41593-022-01213-3.Peer-Reviewed Original ResearchConceptsMagnetic resonance imagingSerotonin neuronsSerotonin receptorsSerotonin regulationDorsal raphe serotonin neuronsReceptor networkResting-state functional magnetic resonance imagingOptogenetic functional magnetic resonance imagingRaphe serotonin neuronsSpecific serotonin receptorsBrain-wide activityFunctional magnetic resonance imagingSerotonin receptor typesDifferent serotonin receptorsBrain-wide distributionSerotonin effectsReceptor typesResonance imagingFunctional connectivityReceptorsNeuronsSingle-cell levelCompelling evidenceFunctional signaturesMultiple aspects
2021
Recent advances in understanding neural correlates of anxiety disorders in children and adolescents
Zugman A, Winkler A, Pine D. Recent advances in understanding neural correlates of anxiety disorders in children and adolescents. Current Opinion In Psychiatry 2021, 34: 617-623. PMID: 34475352, PMCID: PMC8490291, DOI: 10.1097/yco.0000000000000743.Peer-Reviewed Original ResearchConceptsAnxiety disordersBrain regionsMedial prefrontal cortexNeural indicesLow-level threatNeural correlatesSmall effect sizesPrefrontal cortexNeural circuitryBrain circuitryCircuitry dysfunctionBrain connectivityCommon psychiatric diagnosesFearEffect sizeMost mental illnessesStria terminalisBed nucleusAnxietyAdolescentsPsychiatric diagnosisMental illnessRecent workDisordersChildren
2020
White matter structure and myelin-related gene expression alterations with experience in adult rats
Sampaio-Baptista C, Vallès A, Khrapitchev A, Akkermans G, Winkler A, Foxley S, Sibson N, Roberts M, Miller K, Diamond M, Martens G, De Weerd P, Johansen-Berg H. White matter structure and myelin-related gene expression alterations with experience in adult rats. Progress In Neurobiology 2020, 187: 101770. PMID: 32001310, PMCID: PMC7086231, DOI: 10.1016/j.pneurobio.2020.101770.Peer-Reviewed Original ResearchConceptsDiffusion tensor imagingAdult ratsMRNA expressionMyelin basic protein mRNA expressionWM plasticityNeuronal activity modulationMBP protein expressionC-fos mRNA expressionMatter structuresAnalysis of myelinGray matter structuresProtein mRNA expressionWhite matter plasticityRegulation of myelinationWhite matter structuresBarrel cortexGene expression alterationsCortical activityMRNA expression analysisRNA sequencing analysisBrain structuresTensor imagingDTI differencesMacroscale measuresMolecular correlates
2014
Permutation inference for the general linear model
Winkler AM, Ridgway GR, Webster MA, Smith SM, Nichols TE. Permutation inference for the general linear model. NeuroImage 2014, 92: 381-397. PMID: 24530839, PMCID: PMC4010955, DOI: 10.1016/j.neuroimage.2014.01.060.Peer-Reviewed Original ResearchConceptsPermutation inferenceNon-standard statisticsComplex general linear modelArbitrary experimental designsLinear modelPermutation methodOnly weak assumptionsGLM parametersWeak assumptionsSymmetric distributionExact controlGeneral linear modelNuisance variablesInferenceDetailed exampleComplete algorithmAlgorithmExperimental designIndependent dataNuisance effectsUseful caseGeneric frameworkModelStatisticsGLM
2011
Genetic influence on the working memory circuitry: Behavior, structure, function and extensions to illness
Karlsgodt KH, Bachman P, Winkler AM, Bearden CE, Glahn DC. Genetic influence on the working memory circuitry: Behavior, structure, function and extensions to illness. Behavioural Brain Research 2011, 225: 610-622. PMID: 21878355, PMCID: PMC3545474, DOI: 10.1016/j.bbr.2011.08.016.Peer-Reviewed Original ResearchGenetic Architecture of Declarative Memory
Bearden CE, Karlsgodt KH, Bachman P, van Erp TG, Winkler AM, Glahn DC. Genetic Architecture of Declarative Memory. The Neuroscientist 2011, 18: 516-532. PMID: 21832260, PMCID: PMC3545476, DOI: 10.1177/1073858411415113.Peer-Reviewed Original ResearchConceptsGenetic architectureIndependent inheritanceGenetic basisMolecular basisSingle gene disordersMolecular mechanismsGeneralist genesMemory functionHuman memory functionLong-term memoryDistinct aspectsGenesDeclarative memoryCognitive domainsMemory abilityDistinct subcomponentsInheritanceMemoryFunctionIndividual variabilityDomainImportant informationEvidence