2014
Assessment of whole brain white matter integrity in youths and young adults with a family history of substance‐use disorders
Acheson A, Wijtenburg S, Rowland L, Winkler A, Gaston F, Mathias C, Fox P, Lovallo W, Wright S, Hong L, Dougherty D, Kochunov P. Assessment of whole brain white matter integrity in youths and young adults with a family history of substance‐use disorders. Human Brain Mapping 2014, 35: 5401-5413. PMID: 24867528, PMCID: PMC4206569, DOI: 10.1002/hbm.22559.Peer-Reviewed Original ResearchConceptsSubstance use disordersLower FA valuesFamily historyUse disordersFA valuesCorona radiataWhole-brain white matter integrityYoung adultsFrontostriatal white matter tractsBrain white matter integrityFrontal white matterPosterior corona radiataAnterior corona radiataFractional anisotropy (FA) dataHigher radial diffusivitySuch family historyWhite matter tractsWhite matter integrityAge-related declineImpaired myelinationAxonal myelinationCorpus callosumGeneral populationWhite matterSignificant negative correlation
2011
High Dimensional Endophenotype Ranking in the Search for Major Depression Risk Genes
Glahn DC, Curran JE, Winkler AM, Carless MA, Kent JW, Charlesworth JC, Johnson MP, Göring HH, Cole SA, Dyer TD, Moses EK, Olvera RL, Kochunov P, Duggirala R, Fox PT, Almasy L, Blangero J. High Dimensional Endophenotype Ranking in the Search for Major Depression Risk Genes. Biological Psychiatry 2011, 71: 6-14. PMID: 21982424, PMCID: PMC3230692, DOI: 10.1016/j.biopsych.2011.08.022.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overChromosomes, Human, Pair 4Cognition DisordersDepressive Disorder, MajorEndophenotypesFamily HealthFemaleGene Expression ProfilingGenetic LinkageGenetic Predisposition to DiseaseGenome-Wide Association StudyGenotypeHumansMagnetic Resonance ImagingMaleMexican AmericansMiddle AgedNeuropsychological TestsOligonucleotide Array Sequence AnalysisPsychiatric Status Rating ScalesQuantitative Trait LociRiskYoung AdultConceptsGenome-wide significant quantitative trait lociSignificant quantitative trait lociQuantitative trait lociGenome-wide significanceBivariate linkage analysisGenetic utilityTrait lociCausal genesDepression genesLinkage analysisRisk genesPleiotropic effectsExtended pedigreesGenesMexican-American individualsObjective endophenotypesExpression levelsUnrelated individualsFamily-based studyIntermediate phenotypesBiological mechanismsUnbiased methodLociTraitsNew insights