2023
Volume of subcortical brain regions in social anxiety disorder: mega-analytic results from 37 samples in the ENIGMA-Anxiety Working Group
Groenewold N, Bas-Hoogendam J, Amod A, Laansma M, Van Velzen L, Aghajani M, Hilbert K, Oh H, Salas R, Jackowski A, Pan P, Salum G, Blair J, Blair K, Hirsch J, Pantazatos S, Schneier F, Talati A, Roelofs K, Volman I, Blanco-Hinojo L, Cardoner N, Pujol J, Beesdo-Baum K, Ching C, Thomopoulos S, Jansen A, Kircher T, Krug A, Nenadić I, Stein F, Dannlowski U, Grotegerd D, Lemke H, Meinert S, Winter A, Erb M, Kreifelts B, Gong Q, Lui S, Zhu F, Mwangi B, Soares J, Wu M, Bayram A, Canli M, Tükel R, Westenberg P, Heeren A, Cremers H, Hofmann D, Straube T, Doruyter A, Lochner C, Peterburs J, Van Tol M, Gur R, Kaczkurkin A, Larsen B, Satterthwaite T, Filippi C, Gold A, Harrewijn A, Zugman A, Bülow R, Grabe H, Völzke H, Wittfeld K, Böhnlein J, Dohm K, Kugel H, Schrammen E, Zwanzger P, Leehr E, Sindermann L, Ball T, Fonzo G, Paulus M, Simmons A, Stein M, Klumpp H, Phan K, Furmark T, Månsson K, Manzouri A, Avery S, Blackford J, Clauss J, Feola B, Harper J, Sylvester C, Lueken U, Veltman D, Winkler A, Jahanshad N, Pine D, Thompson P, Stein D, Van der Wee N. Volume of subcortical brain regions in social anxiety disorder: mega-analytic results from 37 samples in the ENIGMA-Anxiety Working Group. Molecular Psychiatry 2023, 28: 1079-1089. PMID: 36653677, PMCID: PMC10804423, DOI: 10.1038/s41380-022-01933-9.Peer-Reviewed Original ResearchConceptsSocial anxiety disorderSubcortical brain regionsAnxiety disordersSAD patientsBilateral putamen volumesSubcortical regionsBrain regionsLinear mixed effects analysisComorbid anxiety disordersSubcortical volumesFamily-wise errorPutamen volumeSAD onsetVolumetric differencesPallidum volumeMixed effects analysisD effect sizesInconsistent findingsLeft putamenEffect sizeFull samplePrevious findingsInternational sampleSignificant interactionLimited convergence
2022
Serotonin regulation of behavior via large-scale neuromodulation of serotonin receptor networks
Salvan P, Fonseca M, Winkler A, Beauchamp A, Lerch J, Johansen-Berg H. Serotonin regulation of behavior via large-scale neuromodulation of serotonin receptor networks. Nature Neuroscience 2022, 26: 53-63. PMID: 36522497, PMCID: PMC9829536, DOI: 10.1038/s41593-022-01213-3.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDorsal Raphe NucleusHumansMagnetic Resonance ImagingMiceNeuroimagingReceptors, SerotoninSerotoninConceptsMagnetic resonance imagingSerotonin neuronsSerotonin receptorsSerotonin regulationDorsal raphe serotonin neuronsReceptor networkResting-state functional magnetic resonance imagingOptogenetic functional magnetic resonance imagingRaphe serotonin neuronsSpecific serotonin receptorsBrain-wide activityFunctional magnetic resonance imagingSerotonin receptor typesDifferent serotonin receptorsBrain-wide distributionSerotonin effectsReceptor typesResonance imagingFunctional connectivityReceptorsNeuronsSingle-cell levelCompelling evidenceFunctional signaturesMultiple aspects
2021
The Enhancing NeuroImaging Genetics through Meta‐Analysis Consortium: 10 Years of Global Collaborations in Human Brain Mapping
Thompson P, Jahanshad N, Schmaal L, Turner J, Winkler A, Thomopoulos S, Egan G, Kochunov P. The Enhancing NeuroImaging Genetics through Meta‐Analysis Consortium: 10 Years of Global Collaborations in Human Brain Mapping. Human Brain Mapping 2021, 43: 15-22. PMID: 34612558, PMCID: PMC8675422, DOI: 10.1002/hbm.25672.Peer-Reviewed Original ResearchMeSH KeywordsBrain MappingGeneticsHumansMeta-Analysis as TopicMulticenter Studies as TopicNeuroimagingConceptsMagnetic resonance imagingMeta-Analysis (ENIGMA) consortiumEnhancing Neuroimaging GeneticsBrain developmentBrain mappingHuman brain mappingBrain mapping analysisTask-based functional magnetic resonance imagingSubstance use disordersFunctional magnetic resonance imagingPosttraumatic stress disorderHuman brain disordersHuman brain developmentObsessive-compulsive disorderDiffusion magnetic resonance imagingMajor depressionUse disordersBipolar disorderBrain disordersBrain scansResonance imagingMagnetic resonance spectroscopyHuman cortexStress disorderLarge-scale studies
2020
Neuroimaging Association Scores: reliability and validity of aggregate measures of brain structural features linked to mental disorders in youth
Axelrud L, Simioni A, Pine D, Winkler A, Pan P, Sato J, Zugman A, Parker N, Picon F, Jackowski A, Hoexter M, Barker G, Martinot J, Martinot M, Satterthwaite T, Rohde L, Milham M, Barker E, Salum G. Neuroimaging Association Scores: reliability and validity of aggregate measures of brain structural features linked to mental disorders in youth. European Child & Adolescent Psychiatry 2020, 30: 1895-1906. PMID: 33030612, PMCID: PMC9077631, DOI: 10.1007/s00787-020-01653-x.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentBrainHumansMagnetic Resonance ImagingMental DisordersNeuroimagingReproducibility of ResultsConceptsGeneral psychopathologyCortical thicknessBrain featuresSubcortical volumesMental disordersStructural brain featuresInternal consistencyBrain structural featuresHealthy Brain NetworkPsychiatric disordersAssociation scoreSymptomatic domainsHigh internal consistencyPsychopathology assessmentDisordersBrain networksLow internal consistencyEffect sizeBehavioral phenotypesScoresReplicable associationsPsychopathologyWeighted scoreAssociationReplicable markersENIGMA‐anxiety working group: Rationale for and organization of large‐scale neuroimaging studies of anxiety disorders
Bas‐Hoogendam J, Groenewold N, Aghajani M, Freitag G, Harrewijn A, Hilbert K, Jahanshad N, Thomopoulos S, Thompson P, Veltman D, Winkler A, Lueken U, Pine D, van der Wee N, Stein D, Agosta F, Åhs F, An I, Alberton B, Andreescu C, Asami T, Assaf M, Avery S, Nicholas L, Balderston, Barber J, Battaglia M, Bayram A, Beesdo‐Baum K, Benedetti F, Berta R, Björkstrand J, Blackford J, Blair J, Karina S, Blair, Boehme S, Brambilla P, Burkhouse K, Cano M, Canu E, Cardinale E, Cardoner N, Clauss J, Cividini C, Critchley H, Udo, Dannlowski, Deckert J, Demiralp T, Diefenbach G, Domschke K, Doruyter A, Dresler T, Erhardt A, Fallgatter A, Fañanás L, Brandee, Feola, Filippi C, Filippi M, Fonzo G, Forbes E, Fox N, Fredrikson M, Furmark T, Ge T, Gerber A, Gosnell S, Grabe H, Grotegerd D, Gur R, Gur R, Harmer C, Harper J, Heeren A, Hettema J, Hofmann D, Hofmann S, Jackowski A, Andreas, Jansen, Kaczkurkin A, Kingsley E, Kircher T, c M, Kreifelts B, Krug A, Larsen B, Lee S, Leehr E, Leibenluft E, Lochner C, Maggioni E, Makovac E, Mancini M, Manfro G, Månsson K, Meeten F, Michałowski J, Milrod B, Mühlberger A, Lilianne R, Mujica‐Parodi, Munjiza A, Mwangi B, Myers M, Nenadi C, Neufang S, Nielsen J, Oh H, Ottaviani C, Pan P, Pantazatos S, Martin P, Paulus, Perez‐Edgar K, Peñate W, Perino M, Peterburs J, Pfleiderer B, Phan K, Poletti S, Porta‐Casteràs D, Price R, Pujol J, Andrea, Reinecke, Rivero F, Roelofs K, Rosso I, Saemann P, Salas R, Salum G, Satterthwaite T, Schneier F, Schruers K, Schulz S, Schwarzmeier H, Seeger F, Smoller J, Soares J, Stark R, Stein M, Straube B, Straube T, Strawn J, Suarez‐Jimenez B, Boris, Suchan, Sylvester C, Talati A, Tamburo E, Tükel R, van den Heuvel O, Van der Auwera S, van Nieuwenhuizen H, van Tol M, van Velzen L, Bort C, Vermeiren R, Visser R, Volman I, Wannemüller A, Wendt J, Werwath K, Westenberg P, Wiemer J, Katharina, Wittfeld, Wu M, Yang Y, Zilverstand A, Zugman A, Zwiebel H. ENIGMA‐anxiety working group: Rationale for and organization of large‐scale neuroimaging studies of anxiety disorders. Human Brain Mapping 2020, 43: 83-112. PMID: 32618421, PMCID: PMC8805695, DOI: 10.1002/hbm.25100.Peer-Reviewed Original ResearchMeSH KeywordsAnxiety DisordersHumansLimbic SystemMulticenter Studies as TopicNeuroimagingPrefrontal CortexConceptsAnxiety disordersSocial anxiety disorderGeneralized anxiety disorderLarge-scale neuroimaging studiesNeuroscience methodologiesNeuroimaging studiesSpecific phobiaGlobal mental healthClinical neuroscienceMental healthPanic disorderENIGMA consortiumUnique sampleDisordersFuture directionsLow statistical powerSmall sample sizeMega‐analysis methods in ENIGMA: The experience of the generalized anxiety disorder working group
Zugman A, Harrewijn A, Cardinale E, Zwiebel H, Freitag G, Werwath K, Bas‐Hoogendam J, Groenewold N, Aghajani M, Hilbert K, Cardoner N, Porta‐Casteràs D, Gosnell S, Salas R, Blair K, Blair J, Hammoud M, Milad M, Burkhouse K, Phan K, Schroeder H, Strawn J, Beesdo‐Baum K, Thomopoulos S, Grabe H, Van der Auwera S, Wittfeld K, Nielsen J, Buckner R, Smoller J, Mwangi B, Soares J, Wu M, Zunta‐Soares G, Jackowski A, Pan P, Salum G, Assaf M, Diefenbach G, Brambilla P, Maggioni E, Hofmann D, Straube T, Andreescu C, Berta R, Tamburo E, Price R, Manfro G, Critchley H, Makovac E, Mancini M, Meeten F, Ottaviani C, Agosta F, Canu E, Cividini C, Filippi M, Kostić M, Munjiza A, Filippi C, Leibenluft E, Alberton B, Balderston N, Ernst M, Grillon C, Mujica‐Parodi L, van Nieuwenhuizen H, Fonzo G, Paulus M, Stein M, Gur R, Gur R, Kaczkurkin A, Larsen B, Satterthwaite T, Harper J, Myers M, Perino M, Yu Q, Sylvester C, Veltman D, Lueken U, Van der Wee N, Stein D, Jahanshad N, Thompson P, Pine D, Winkler A. Mega‐analysis methods in ENIGMA: The experience of the generalized anxiety disorder working group. Human Brain Mapping 2020, 43: 255-277. PMID: 32596977, PMCID: PMC8675407, DOI: 10.1002/hbm.25096.Peer-Reviewed Original ResearchPermutation inference for canonical correlation analysis
Winkler A, Renaud O, Smith S, Nichols T. Permutation inference for canonical correlation analysis. NeuroImage 2020, 220: 117065. PMID: 32603857, PMCID: PMC7573815, DOI: 10.1016/j.neuroimage.2020.117065.Peer-Reviewed Original ResearchENIGMA and global neuroscience: A decade of large-scale studies of the brain in health and disease across more than 40 countries
Thompson PM, Jahanshad N, Ching CRK, Salminen LE, Thomopoulos SI, Bright J, Baune BT, Bertolín S, Bralten J, Bruin WB, Bülow R, Chen J, Chye Y, Dannlowski U, de Kovel CGF, Donohoe G, Eyler LT, Faraone SV, Favre P, Filippi CA, Frodl T, Garijo D, Gil Y, Grabe HJ, Grasby KL, Hajek T, Han LKM, Hatton SN, Hilbert K, Ho TC, Holleran L, Homuth G, Hosten N, Houenou J, Ivanov I, Jia T, Kelly S, Klein M, Kwon JS, Laansma MA, Leerssen J, Lueken U, Nunes A, Neill J, Opel N, Piras F, Piras F, Postema MC, Pozzi E, Shatokhina N, Soriano-Mas C, Spalletta G, Sun D, Teumer A, Tilot AK, Tozzi L, van der Merwe C, Van Someren EJW, van Wingen GA, Völzke H, Walton E, Wang L, Winkler AM, Wittfeld K, Wright MJ, Yun JY, Zhang G, Zhang-James Y, Adhikari BM, Agartz I, Aghajani M, Aleman A, Althoff RR, Altmann A, Andreassen OA, Baron DA, Bartnik-Olson BL, Marie Bas-Hoogendam J, Baskin-Sommers AR, Bearden CE, Berner LA, Boedhoe PSW, Brouwer RM, Buitelaar JK, Caeyenberghs K, Cecil CAM, Cohen RA, Cole JH, Conrod PJ, De Brito SA, de Zwarte SMC, Dennis EL, Desrivieres S, Dima D, Ehrlich S, Esopenko C, Fairchild G, Fisher SE, Fouche JP, Francks C, Frangou S, Franke B, Garavan HP, Glahn DC, Groenewold NA, Gurholt TP, Gutman BA, Hahn T, Harding IH, Hernaus D, Hibar DP, Hillary FG, Hoogman M, Hulshoff Pol HE, Jalbrzikowski M, Karkashadze GA, Klapwijk ET, Knickmeyer RC, Kochunov P, Koerte IK, Kong XZ, Liew SL, Lin AP, Logue MW, Luders E, Macciardi F, Mackey S, Mayer AR, McDonald CR, McMahon AB, Medland SE, Modinos G, Morey RA, Mueller SC, Mukherjee P, Namazova-Baranova L, Nir TM, Olsen A, Paschou P, Pine DS, Pizzagalli F, Rentería ME, Rohrer JD, Sämann PG, Schmaal L, Schumann G, Shiroishi MS, Sisodiya SM, Smit DJA, Sønderby IE, Stein DJ, Stein JL, Tahmasian M, Tate DF, Turner JA, van den Heuvel OA, van der Wee NJA, van der Werf YD, van Erp TGM, van Haren NEM, van Rooij D, van Velzen LS, Veer IM, Veltman DJ, Villalon-Reina JE, Walter H, Whelan CD, Wilde EA, Zarei M, Zelman V. ENIGMA and global neuroscience: A decade of large-scale studies of the brain in health and disease across more than 40 countries. Translational Psychiatry 2020, 10: 100. PMID: 32198361, PMCID: PMC7083923, DOI: 10.1038/s41398-020-0705-1.Peer-Reviewed Original ResearchMeSH KeywordsBrainDepressive Disorder, MajorHumansMagnetic Resonance ImagingNeuroimagingReproducibility of ResultsConceptsAttention-deficit/hyperactivity disorderPost-traumatic stress disorderAutism spectrum disorderObsessive-compulsive disorderDissociative identity disorderBrain systemsSubstance use disordersHyperactivity disorderSpectrum disorderStress disorderConduct disorderAnxiety disordersBrain metricsDiverse samplePsychosocial factorsIdentity disorderAntisocial personalityHuman brainSuicidal thoughtsUse disordersHarmonized analysesGender differencesRobustness of findingsNeuroscienceBrain injuryMultiple testing correction over contrasts for brain imaging
Alberton B, Nichols T, Gamba H, Winkler A. Multiple testing correction over contrasts for brain imaging. NeuroImage 2020, 216: 116760. PMID: 32201328, PMCID: PMC8191638, DOI: 10.1016/j.neuroimage.2020.116760.Peer-Reviewed Original Research
2016
Faster permutation inference in brain imaging
Winkler AM, Ridgway GR, Douaud G, Nichols TE, Smith SM. Faster permutation inference in brain imaging. NeuroImage 2016, 141: 502-516. PMID: 27288322, PMCID: PMC5035139, DOI: 10.1016/j.neuroimage.2016.05.068.Peer-Reviewed Original ResearchConceptsGamma distributionPermutation distributionProperties of statisticsReal data exampleInexpensive computing powerLinear modelGeneralised Pareto distributionMatrix theoryTail approximationNegative binomial distributionSymmetric errorsPareto distributionDirect fittingFamily-wise error ratePermutation inferenceReference resultsComplex modelsBinomial distributionReal dataSynthetic dataExact error rateComputing powerGeneral linear modelFamilywise errorNull hypothesisNon‐parametric combination and related permutation tests for neuroimaging
Winkler AM, Webster MA, Brooks JC, Tracey I, Smith SM, Nichols TE. Non‐parametric combination and related permutation tests for neuroimaging. Human Brain Mapping 2016, 37: 1486-1511. PMID: 26848101, PMCID: PMC4783210, DOI: 10.1002/hbm.23115.Peer-Reviewed Original Research
2015
Fast and powerful heritability inference for family-based neuroimaging studies
Ganjgahi H, Winkler AM, Glahn DC, Blangero J, Kochunov P, Nichols TE. Fast and powerful heritability inference for family-based neuroimaging studies. NeuroImage 2015, 115: 256-268. PMID: 25812717, PMCID: PMC4463976, DOI: 10.1016/j.neuroimage.2015.03.005.Peer-Reviewed Original ResearchConceptsAuxiliary linear modelSemi-parametric inferenceInference methodsP-value computationParametric inference methodsNovel inference methodSum of squaresMultiple testing problemLikelihood computationInference proceduresFast estimationStandard resultsComputational intensityData settingTesting problemLinear modelPermutation schemeMethodological resultsAnisotropy measuresSignificance testsComputationInferenceWald testFalse positive riskHeritability estimation
2013
Genetic basis of neurocognitive decline and reduced white-matter integrity in normal human brain aging
Glahn DC, Kent JW, Sprooten E, Diego VP, Winkler AM, Curran JE, McKay DR, Knowles EE, Carless MA, Göring HH, Dyer TD, Olvera RL, Fox PT, Almasy L, Charlesworth J, Kochunov P, Duggirala R, Blangero J. Genetic basis of neurocognitive decline and reduced white-matter integrity in normal human brain aging. Proceedings Of The National Academy Of Sciences Of The United States Of America 2013, 110: 19006-19011. PMID: 24191011, PMCID: PMC3839730, DOI: 10.1073/pnas.1313735110.Peer-Reviewed Original ResearchReduced White Matter Integrity in Sibling Pairs Discordant for Bipolar Disorder
Sprooten E, Brumbaugh MS, Knowles EE, McKay DR, Lewis J, Barrett J, Landau S, Cyr L, Kochunov P, Winkler AM, Pearlson GD, Glahn DC. Reduced White Matter Integrity in Sibling Pairs Discordant for Bipolar Disorder. American Journal Of Psychiatry 2013, 170: 1317-1325. PMID: 24185242, PMCID: PMC4119087, DOI: 10.1176/appi.ajp.2013.12111462.Peer-Reviewed Original Research
2012
Identification of common variants associated with human hippocampal and intracranial volumes
Stein JL, Medland SE, Vasquez AA, Hibar DP, Senstad RE, Winkler AM, Toro R, Appel K, Bartecek R, Bergmann Ø, Bernard M, Brown AA, Cannon DM, Chakravarty MM, Christoforou A, Domin M, Grimm O, Hollinshead M, Holmes AJ, Homuth G, Hottenga JJ, Langan C, Lopez LM, Hansell NK, Hwang KS, Kim S, Laje G, Lee PH, Liu X, Loth E, Lourdusamy A, Mattingsdal M, Mohnke S, Maniega SM, Nho K, Nugent AC, O'Brien C, Papmeyer M, Pütz B, Ramasamy A, Rasmussen J, Rijpkema M, Risacher SL, Roddey JC, Rose EJ, Ryten M, Shen L, Sprooten E, Strengman E, Teumer A, Trabzuni D, Turner J, van Eijk K, van Erp TG, van Tol MJ, Wittfeld K, Wolf C, Woudstra S, Aleman A, Alhusaini S, Almasy L, Binder EB, Brohawn DG, Cantor RM, Carless MA, Corvin A, Czisch M, Curran JE, Davies G, de Almeida MA, Delanty N, Depondt C, Duggirala R, Dyer TD, Erk S, Fagerness J, Fox PT, Freimer NB, Gill M, Göring HH, Hagler DJ, Hoehn D, Holsboer F, Hoogman M, Hosten N, Jahanshad N, Johnson MP, Kasperaviciute D, Kent JW, Kochunov P, Lancaster JL, Lawrie SM, Liewald DC, Mandl R, Matarin M, Mattheisen M, Meisenzahl E, Melle I, Moses EK, Mühleisen TW, Nauck M, Nöthen MM, Olvera RL, Pandolfo M, Pike GB, Puls R, Reinvang I, Rentería ME, Rietschel M, Roffman JL, Royle NA, Rujescu D, Savitz J, Schnack HG, Schnell K, Seiferth N, Smith C, Steen VM, Valdés Hernández MC, Van den Heuvel M, van der Wee NJ, Van Haren NE, Veltman JA, Völzke H, Walker R, Westlye LT, Whelan CD, Agartz I, Boomsma DI, Cavalleri GL, Dale AM, Djurovic S, Drevets WC, Hagoort P, Hall J, Heinz A, Jack CR, Foroud TM, Le Hellard S, Macciardi F, Montgomery GW, Poline JB, Porteous DJ, Sisodiya SM, Starr JM, Sussmann J, Toga AW, Veltman DJ, Walter H, Weiner MW, Bis J, Ikram M, Smith A, Gudnason V, Tzourio C, Vernooij M, Launer L, DeCarli C, Seshadri S, Andreassen O, Apostolova L, Bastin M, Blangero J, Brunner H, Buckner R, Cichon S, Coppola G, de Zubicaray G, Deary I, Donohoe G, de Geus E, Espeseth T, Fernández G, Glahn D, Grabe H, Hardy J, Hulshoff Pol H, Jenkinson M, Kahn R, McDonald C, McIntosh A, McMahon F, McMahon K, Meyer-Lindenberg A, Morris D, Müller-Myhsok B, Nichols T, Ophoff R, Paus T, Pausova Z, Penninx B, Potkin S, Sämann P, Saykin A, Schumann G, Smoller J, Wardlaw J, Weale M, Martin N, Franke B, Wright M, Thompson P. Identification of common variants associated with human hippocampal and intracranial volumes. Nature Genetics 2012, 44: 552-561. PMID: 22504417, PMCID: PMC3635491, DOI: 10.1038/ng.2250.Peer-Reviewed Original Research
2011
Genetic influence on the working memory circuitry: Behavior, structure, function and extensions to illness
Karlsgodt KH, Bachman P, Winkler AM, Bearden CE, Glahn DC. Genetic influence on the working memory circuitry: Behavior, structure, function and extensions to illness. Behavioural Brain Research 2011, 225: 610-622. PMID: 21878355, PMCID: PMC3545474, DOI: 10.1016/j.bbr.2011.08.016.Peer-Reviewed Original Research