Analysis of Genetic Variability and Whole Genome Linkage of Whole-Brain, Subcortical, and Ependymal Hyperintense White Matter Volume
Kochunov P, Glahn D, Winkler A, Duggirala R, Olvera RL, Cole S, Dyer TD, Almasy L, Fox PT, Blangero J. Analysis of Genetic Variability and Whole Genome Linkage of Whole-Brain, Subcortical, and Ependymal Hyperintense White Matter Volume. Stroke 2009, 40: 3685-3690. PMID: 19834011, PMCID: PMC2787844, DOI: 10.1161/strokeaha.109.565390.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAgingBiomarkersBrain IschemiaCerebrospinal Fluid PressureCerebrumChromosome MappingCohort StudiesDisease ProgressionDNA Mutational AnalysisEpendymaFemaleGenetic LinkageGenetic Predisposition to DiseaseGenetic TestingGenetic VariationHumansIntracranial HypertensionLeukoencephalopathiesMagnetic Resonance ImagingMaleMexican AmericansMiddle AgedNerve Fibers, MyelinatedYoung AdultConceptsArterial pulse pressurePulse pressureImportant neuroimaging markerFluid-attenuated inversion recovery imagesCommon risk factorsWhite matter volumeYears of ageInversion recovery imagesHealthy Mexican AmericansHWM volumeFamily Heart StudyRisk factorsCerebral volumeNeuroimaging markerHeart StudyMatter volumeWhite matterWhole brainPathophysiology studiesCerebral integritySan Antonio Family Heart StudyRecovery imagesMexican AmericansWhole-genome linkageGenome linkage