2021
Reassessing associations between white matter and behaviour with multimodal microstructural imaging
Lazari A, Salvan P, Cottaar M, Papp D, van der Werf O, Johnstone A, Sanders Z, Sampaio-Baptista C, Eichert N, Miyamoto K, Winkler A, Callaghan M, Nichols T, Stagg C, Rushworth M, Verhagen L, Johansen-Berg H. Reassessing associations between white matter and behaviour with multimodal microstructural imaging. Cortex 2021, 145: 187-200. PMID: 34742100, PMCID: PMC8940642, DOI: 10.1016/j.cortex.2021.08.017.Peer-Reviewed Original Research
2018
Fast and powerful genome wide association of dense genetic data with high dimensional imaging phenotypes
Ganjgahi H, Winkler AM, Glahn DC, Blangero J, Donohue B, Kochunov P, Nichols TE. Fast and powerful genome wide association of dense genetic data with high dimensional imaging phenotypes. Nature Communications 2018, 9: 3254. PMID: 30108209, PMCID: PMC6092439, DOI: 10.1038/s41467-018-05444-6.Peer-Reviewed Original Research
2015
The common genetic influence over processing speed and white matter microstructure: Evidence from the Old Order Amish and Human Connectome Projects
Kochunov P, Thompson P, Winkler A, Morrissey M, Fu M, Coyle T, Du X, Muellerklein F, Savransky A, Gaudiot C, Sampath H, Eskandar G, Jahanshad N, Patel B, Rowland L, Nichols T, O'Connell J, Shuldiner A, Mitchell B, Hong L. The common genetic influence over processing speed and white matter microstructure: Evidence from the Old Order Amish and Human Connectome Projects. NeuroImage 2015, 125: 189-197. PMID: 26499807, PMCID: PMC4691385, DOI: 10.1016/j.neuroimage.2015.10.050.Peer-Reviewed Original ResearchFast and powerful heritability inference for family-based neuroimaging studies
Ganjgahi H, Winkler AM, Glahn DC, Blangero J, Kochunov P, Nichols TE. Fast and powerful heritability inference for family-based neuroimaging studies. NeuroImage 2015, 115: 256-268. PMID: 25812717, PMCID: PMC4463976, DOI: 10.1016/j.neuroimage.2015.03.005.Peer-Reviewed Original ResearchConceptsAuxiliary linear modelSemi-parametric inferenceInference methodsP-value computationParametric inference methodsNovel inference methodSum of squaresMultiple testing problemLikelihood computationInference proceduresFast estimationStandard resultsComputational intensityData settingTesting problemLinear modelPermutation schemeMethodological resultsAnisotropy measuresSignificance testsComputationInferenceWald testFalse positive riskHeritability estimationHeritability of fractional anisotropy in human white matter: A comparison of Human Connectome Project and ENIGMA-DTI data
Kochunov P, Jahanshad N, Marcus D, Winkler A, Sprooten E, Nichols TE, Wright SN, Hong LE, Patel B, Behrens T, Jbabdi S, Andersson J, Lenglet C, Yacoub E, Moeller S, Auerbach E, Ugurbil K, Sotiropoulos SN, Brouwer RM, Landman B, Lemaitre H, Braber A, Zwiers MP, Ritchie S, van Hulzen K, Almasy L, Curran J, deZubicaray GI, Duggirala R, Fox P, Martin NG, McMahon KL, Mitchell B, Olvera RL, Peterson C, Starr J, Sussmann J, Wardlaw J, Wright M, Boomsma DI, Kahn R, de Geus EJ, Williamson DE, Hariri A, van 't Ent D, Bastin ME, McIntosh A, Deary IJ, pol H, Blangero J, Thompson PM, Glahn DC, Van Essen DC. Heritability of fractional anisotropy in human white matter: A comparison of Human Connectome Project and ENIGMA-DTI data. NeuroImage 2015, 111: 300-311. PMID: 25747917, PMCID: PMC4387079, DOI: 10.1016/j.neuroimage.2015.02.050.Peer-Reviewed Original Research
2013
Influence of age, sex and genetic factors on the human brain
McKay DR, Knowles EE, Winkler AA, Sprooten E, Kochunov P, Olvera RL, Curran JE, Kent JW, Carless MA, Göring HH, Dyer TD, Duggirala R, Almasy L, Fox PT, Blangero J, Glahn DC. Influence of age, sex and genetic factors on the human brain. Brain Imaging And Behavior 2013, 8: 143-152. PMID: 24297733, PMCID: PMC4011973, DOI: 10.1007/s11682-013-9277-5.Peer-Reviewed Original ResearchGenetic basis of neurocognitive decline and reduced white-matter integrity in normal human brain aging
Glahn DC, Kent JW, Sprooten E, Diego VP, Winkler AM, Curran JE, McKay DR, Knowles EE, Carless MA, Göring HH, Dyer TD, Olvera RL, Fox PT, Almasy L, Charlesworth J, Kochunov P, Duggirala R, Blangero J. Genetic basis of neurocognitive decline and reduced white-matter integrity in normal human brain aging. Proceedings Of The National Academy Of Sciences Of The United States Of America 2013, 110: 19006-19011. PMID: 24191011, PMCID: PMC3839730, DOI: 10.1073/pnas.1313735110.Peer-Reviewed Original ResearchReduced White Matter Integrity in Sibling Pairs Discordant for Bipolar Disorder
Sprooten E, Brumbaugh MS, Knowles EE, McKay DR, Lewis J, Barrett J, Landau S, Cyr L, Kochunov P, Winkler AM, Pearlson GD, Glahn DC. Reduced White Matter Integrity in Sibling Pairs Discordant for Bipolar Disorder. American Journal Of Psychiatry 2013, 170: 1317-1325. PMID: 24185242, PMCID: PMC4119087, DOI: 10.1176/appi.ajp.2013.12111462.Peer-Reviewed Original Research
2010
Blood Pressure and Cerebral White Matter Share Common Genetic Factors in Mexican Americans
Kochunov P, Glahn DC, Lancaster J, Winkler A, Karlsgodt K, Olvera RL, Curran JE, Carless MA, Dyer TD, Almasy L, Duggirala R, Fox PT, Blangero J. Blood Pressure and Cerebral White Matter Share Common Genetic Factors in Mexican Americans. Hypertension 2010, 57: 330-335. PMID: 21135356, PMCID: PMC3024472, DOI: 10.1161/hypertensionaha.110.162206.Peer-Reviewed Original ResearchA Multimodal Assessment of the Genetic Control over Working Memory
Karlsgodt KH, Kochunov P, Winkler AM, Laird AR, Almasy L, Duggirala R, Olvera RL, Fox PT, Blangero J, Glahn DC. A Multimodal Assessment of the Genetic Control over Working Memory. Journal Of Neuroscience 2010, 30: 8197-8202. PMID: 20554870, PMCID: PMC2894480, DOI: 10.1523/jneurosci.0359-10.2010.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAnisotropyBrainBrain MappingDiffusion Magnetic Resonance ImagingFemaleHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleMemory, Short-TermMexican AmericansMiddle AgedNerve Fibers, MyelinatedNeural PathwaysNeuropsychological TestsOxygenPedigreeYoung AdultConceptsMemory performanceComplex cognitive functionsHigher-level processesGray matter densityWorking memoryCognitive measuresResponse taskStructural magnetic resonanceGeneral intelligenceSuperior longitudinal fasciculusHuman participantsWhite matter tractsCognitive functionCognitive deficitsOnly performanceMultimodal assessmentBrain regionsMemoryCommon genetic factorsLongitudinal fasciculusMajor white matter tractsLevel processesMeasuresGray matter regionsCore componentGenetics of microstructure of cerebral white matter using diffusion tensor imaging
Kochunov P, Glahn DC, Lancaster JL, Winkler AM, Smith S, Thompson PM, Almasy L, Duggirala R, Fox PT, Blangero J. Genetics of microstructure of cerebral white matter using diffusion tensor imaging. NeuroImage 2010, 53: 1109-1116. PMID: 20117221, PMCID: PMC2888778, DOI: 10.1016/j.neuroimage.2010.01.078.Peer-Reviewed Original Research