2021
An In-vivo 1H-MRS short-echo time technique at 7T: Quantification of metabolites in chronic multiple sclerosis and neuromyelitis optica brain lesions and normal appearing brain tissue
Tackley G, Kong Y, Minne R, Messina S, Winkler A, Cavey A, Everett R, DeLuca G, Weir A, Craner M, Tracey I, Palace J, Stagg C, Emir U. An In-vivo 1H-MRS short-echo time technique at 7T: Quantification of metabolites in chronic multiple sclerosis and neuromyelitis optica brain lesions and normal appearing brain tissue. NeuroImage 2021, 238: 118225. PMID: 34062267, PMCID: PMC7611458, DOI: 10.1016/j.neuroimage.2021.118225.Peer-Reviewed Original ResearchConceptsTotal N-acetylaspartateMultiple sclerosisN-acetylaspartateBrain lesionsPositive neuromyelitis optica spectrum disorderWhite matterNeuromyelitis optica spectrum disorderOptica spectrum disorderChronic multiple sclerosisPost-hoc testingBrain white matterDisease groupMRS methodologyMRS profilesMRS studiesReciprocal findingsNon-invasive quantificationBrain tissueLesionsMagnetic resonance spectroscopyMyo-inositolDistinct diseasesNormal tissuesCNS moleculesIn-Vivo
2015
Striatal activity and reduced white matter increase frontal activity in youths with family histories of alcohol and other substance‐use disorders performing a go/no‐go task
Acheson A, Tagamets M, Winkler A, Rowland L, Mathias C, Wright S, Hong L, Kochunov P, Dougherty D. Striatal activity and reduced white matter increase frontal activity in youths with family histories of alcohol and other substance‐use disorders performing a go/no‐go task. Brain And Behavior 2015, 5: e00352. PMID: 26221573, PMCID: PMC4511289, DOI: 10.1002/brb3.352.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAspartic AcidBrain MappingChildCorpus StriatumExecutive FunctionFamilyFemaleGenetic Predisposition to DiseaseHumansInhibition, PsychologicalLongitudinal StudiesMagnetic Resonance ImagingMaleMotor CortexNeural PathwaysProton Magnetic Resonance SpectroscopyPsychomotor PerformanceSignal Processing, Computer-AssistedSubstance-Related DisordersWhite MatterConceptsSupplementary motor areaSubstance use disordersWhite matter integrityFamily historyFrontal white matter integrityStriatal activityDorsal striatumFrontal cortical activityCortical activitySMA activityFrontal cortical projectionsDrug use disordersDorsal striatal activitySuch family historyDorsal striatum activityCortical projectionsMotor areaElevated riskOngoing longitudinal studyUse disordersWhite matterDownstream projectionsGo/