2022
Threat imminence reveals links among unfolding of anticipatory physiological response, cortical-subcortical intrinsic functional connectivity, and anxiety
Abend R, Ruiz S, Bajaj M, Harrewijn A, Linke J, Atlas L, Winkler A, Pine D. Threat imminence reveals links among unfolding of anticipatory physiological response, cortical-subcortical intrinsic functional connectivity, and anxiety. Neurobiology Of Stress 2022, 16: 100428. PMID: 35036479, PMCID: PMC8749274, DOI: 10.1016/j.ynstr.2022.100428.Peer-Reviewed Original ResearchThreat imminenceAnticipatory physiological responsesAnxiety effectsPathological anxietyResting-state functional connectivity dataNon-painful thermal stimulationThreat-anticipation taskAnticipation of threatVentromedial prefrontal cortexIntrinsic functional connectivityFunctional connectivity dataDefensive responsesCortical-subcortical circuitsBasic neuroscience researchAnticipatory respondingPhysiological respondingDefensive respondingFear responsesMultivariate network analysisIntrinsic connectivityPrefrontal cortexAnxiety patientsNeuroscience researchPhysiological responsesFunctional connectivity
2021
Recent advances in understanding neural correlates of anxiety disorders in children and adolescents
Zugman A, Winkler A, Pine D. Recent advances in understanding neural correlates of anxiety disorders in children and adolescents. Current Opinion In Psychiatry 2021, 34: 617-623. PMID: 34475352, PMCID: PMC8490291, DOI: 10.1097/yco.0000000000000743.Peer-Reviewed Original ResearchConceptsAnxiety disordersBrain regionsMedial prefrontal cortexNeural indicesLow-level threatNeural correlatesSmall effect sizesPrefrontal cortexNeural circuitryBrain circuitryCircuitry dysfunctionBrain connectivityCommon psychiatric diagnosesFearEffect sizeMost mental illnessesStria terminalisBed nucleusAnxietyAdolescentsPsychiatric diagnosisMental illnessRecent workDisordersChildren
2010
Genetic control over the resting brain
Glahn DC, Winkler AM, Kochunov P, Almasy L, Duggirala R, Carless MA, Curran JC, Olvera RL, Laird AR, Smith SM, Beckmann CF, Fox PT, Blangero J. Genetic control over the resting brain. Proceedings Of The National Academy Of Sciences Of The United States Of America 2010, 107: 1223-1228. PMID: 20133824, PMCID: PMC2824276, DOI: 10.1073/pnas.0909969107.Peer-Reviewed Original ResearchConceptsDefault-mode functional connectivityDefault mode connectivityFunctional connectivityDefault mode networkGenetic factorsPosterior cingulate/precuneus regionBasal neural activityResting-state brain networksGray matter densityMedial prefrontal cortexLeft parahippocampal regionIntrinsic brain functionPsychiatric illnessNeurological illnessNeurophysiologic mechanismsAnatomic variationsRight cerebellumSuch illnessesParahippocampal regionBrain functionPrecuneus regionsPrefrontal cortexIllnessGenetic riskNeural activity