2016
Heterochronicity of white matter development and aging explains regional patient control differences in schizophrenia
Kochunov P, Ganjgahi H, Winkler A, Kelly S, Shukla D, Du X, Jahanshad N, Rowland L, Sampath H, Patel B, O'Donnell P, Xie Z, Paciga S, Schubert C, Chen J, Zhang G, Thompson P, Nichols T, Hong L. Heterochronicity of white matter development and aging explains regional patient control differences in schizophrenia. Human Brain Mapping 2016, 37: 4673-4688. PMID: 27477775, PMCID: PMC5118078, DOI: 10.1002/hbm.23336.Peer-Reviewed Original ResearchConceptsAge-related declineWhite matterSchizophrenia patientsFractional anisotropyFA valuesDiagnosis interactionFaster age-related declinePathophysiology of schizophreniaHum Brain MappEffect of diagnosisLower fractional anisotropyPatient-control differencesT Siemens MRI scannerBrain white matterClinical burdenRegional FA valuesPatientsAbnormal rateBrain connectivityTract developmentAdolescent maturationSpecific tractsRegional reductionDiagnosisSchizophrenia
2015
Perfusion shift from white to gray matter may account for processing speed deficits in schizophrenia
Wright S, Hong L, Winkler A, Chiappelli J, Nugent K, Muellerklein F, Du X, Rowland L, Wang D, Kochunov P. Perfusion shift from white to gray matter may account for processing speed deficits in schizophrenia. Human Brain Mapping 2015, 36: 3793-3804. PMID: 26108347, PMCID: PMC4714540, DOI: 10.1002/hbm.22878.Peer-Reviewed Original ResearchConceptsWM integrityDiffusion tensor imagingArterial spin labelingPatient-control differencesPS deficitsReduced WM integrityPerfusion shiftCerebral information processingLower WM integrityCerebral WMNeurophysiological alterationsInformation processing speedSchizophrenia patientsGray matterCognitive deficitsTensor imagingBlood perfusionSchizophreniaDeficitsFurther examinationSpin labelingProcessing speedPatientsCohortPerfusion