Transcriptomics of cortical gray matter thickness decline during normal aging
Kochunov P, Charlesworth J, Winkler A, Hong LE, Nichols TE, Curran JE, Sprooten E, Jahanshad N, Thompson PM, Johnson MP, Kent JW, Landman BA, Mitchell B, Cole SA, Dyer TD, Moses EK, Goring HH, Almasy L, Duggirala R, Olvera RL, Glahn DC, Blangero J. Transcriptomics of cortical gray matter thickness decline during normal aging. NeuroImage 2013, 82: 273-283. PMID: 23707588, PMCID: PMC3759649, DOI: 10.1016/j.neuroimage.2013.05.066.Peer-Reviewed Original ResearchConceptsPathway enrichment analysisTranscriptome dataInnate immune pathwaysEnrichment analysisCellular proliferationInnate immune response pathwaysImmune pathwaysImmune response pathwaysResponse pathwaysFunctional categoriesPathway enrichmentTranscriptional activityGenesExpression activityTranscriptsHigh-resolution T1-weighted MRINormal cerebral agingCommunity-dwelling membersPathwaySignificance thresholdRegenerative capacityT1-weighted MRIDifferentiationCerebral agingViral infection