Perfusion shift from white to gray matter may account for processing speed deficits in schizophrenia
Wright S, Hong L, Winkler A, Chiappelli J, Nugent K, Muellerklein F, Du X, Rowland L, Wang D, Kochunov P. Perfusion shift from white to gray matter may account for processing speed deficits in schizophrenia. Human Brain Mapping 2015, 36: 3793-3804. PMID: 26108347, PMCID: PMC4714540, DOI: 10.1002/hbm.22878.Peer-Reviewed Original ResearchConceptsWM integrityDiffusion tensor imagingArterial spin labelingPatient-control differencesPS deficitsReduced WM integrityPerfusion shiftCerebral information processingLower WM integrityCerebral WMNeurophysiological alterationsInformation processing speedSchizophrenia patientsGray matterCognitive deficitsTensor imagingBlood perfusionSchizophreniaDeficitsFurther examinationSpin labelingProcessing speedPatientsCohortPerfusion