SARS-CoV-2 is associated with changes in brain structure in UK Biobank
Douaud G, Lee S, Alfaro-Almagro F, Arthofer C, Wang C, McCarthy P, Lange F, Andersson J, Griffanti L, Duff E, Jbabdi S, Taschler B, Keating P, Winkler A, Collins R, Matthews P, Allen N, Miller K, Nichols T, Smith S. SARS-CoV-2 is associated with changes in brain structure in UK Biobank. Nature 2022, 604: 697-707. PMID: 35255491, PMCID: PMC9046077, DOI: 10.1038/s41586-022-04569-5.Peer-Reviewed Original ResearchConceptsSARS-CoV-2Pre-existing risk factorsSARS-CoV-2 infectionSARS-CoV-2 casesPrimary olfactory cortexGreater reductionUK BiobankGreater cognitive declineMagnetic resonance imagingGray matter thicknessLongitudinal effectsNeuroinflammatory eventsRisk factorsOlfactory cortexMild casesBrain changesBrain pathologyCOVID-191Parahippocampal gyrusBrain imaging resultsCognitive declineTissue damageResonance imagingOlfactory pathwayOrbitofrontal cortex