Neuroimaging Association Scores: reliability and validity of aggregate measures of brain structural features linked to mental disorders in youth
Axelrud L, Simioni A, Pine D, Winkler A, Pan P, Sato J, Zugman A, Parker N, Picon F, Jackowski A, Hoexter M, Barker G, Martinot J, Martinot M, Satterthwaite T, Rohde L, Milham M, Barker E, Salum G. Neuroimaging Association Scores: reliability and validity of aggregate measures of brain structural features linked to mental disorders in youth. European Child & Adolescent Psychiatry 2020, 30: 1895-1906. PMID: 33030612, PMCID: PMC9077631, DOI: 10.1007/s00787-020-01653-x.Peer-Reviewed Original ResearchConceptsGeneral psychopathologyCortical thicknessBrain featuresSubcortical volumesMental disordersStructural brain featuresInternal consistencyBrain structural featuresHealthy Brain NetworkPsychiatric disordersAssociation scoreSymptomatic domainsHigh internal consistencyPsychopathology assessmentDisordersBrain networksLow internal consistencyEffect sizeBehavioral phenotypesScoresReplicable associationsPsychopathologyWeighted scoreAssociationReplicable markers