2019
One-year changes in brain microstructure differentiate preclinical Huntington's disease stages
Pflanz C, Charquero-Ballester M, Majid D, Winkler A, Vallée E, Aron A, Jenkinson M, Douaud G. One-year changes in brain microstructure differentiate preclinical Huntington's disease stages. NeuroImage Clinical 2019, 25: 102099. PMID: 31865023, PMCID: PMC6931230, DOI: 10.1016/j.nicl.2019.102099.Peer-Reviewed Original ResearchConceptsOnset of symptomsPreclinical stageDisease stageMean diffusivityHuntington's diseaseGender-matched healthy controlsOnly clinical measurePosterior basal gangliaDistinct pathophysiological mechanismsOptimal therapeutic windowOne-year changeSignificant differencesPreclinical Huntington's diseasePresymptomatic Huntington's diseaseNeurodegenerative phaseNeuroinflammatory processesMotor scoresPathophysiological mechanismsBasal gangliaDisease progressionHealthy controlsHuntington's disease stagesCorpus callosumTreatment responseClinical measures
2016
Investigating resting-state functional connectivity in the cervical spinal cord at 3T
Eippert F, Kong Y, Winkler A, Andersson J, Finsterbusch J, Büchel C, Brooks J, Tracey I. Investigating resting-state functional connectivity in the cervical spinal cord at 3T. NeuroImage 2016, 147: 589-601. PMID: 28027960, PMCID: PMC5315056, DOI: 10.1016/j.neuroimage.2016.12.072.Peer-Reviewed Original ResearchConceptsCervical spinal cordSpinal cord injurySpinal cordVentral hornCord injuryResting-state functional connectivityMagnetic resonance imaging studyResting-state connectivityResonance imaging studyFunctional magnetic resonance imaging studyLevel-dependent signalHealthy human participantsNon-human primatesDorsal hornDisease progressionTreatment responseEffects of pathologyNeurological conditionsSpinal segmentsResting-state signalsImaging studiesCordFunctional connectivitySpinal componentsSpontaneous fluctuations