Fast and powerful heritability inference for family-based neuroimaging studies
Ganjgahi H, Winkler AM, Glahn DC, Blangero J, Kochunov P, Nichols TE. Fast and powerful heritability inference for family-based neuroimaging studies. NeuroImage 2015, 115: 256-268. PMID: 25812717, PMCID: PMC4463976, DOI: 10.1016/j.neuroimage.2015.03.005.Peer-Reviewed Original ResearchConceptsAuxiliary linear modelSemi-parametric inferenceInference methodsP-value computationParametric inference methodsNovel inference methodSum of squaresMultiple testing problemLikelihood computationInference proceduresFast estimationStandard resultsComputational intensityData settingTesting problemLinear modelPermutation schemeMethodological resultsAnisotropy measuresSignificance testsComputationInferenceWald testFalse positive riskHeritability estimation