2022
Threat imminence reveals links among unfolding of anticipatory physiological response, cortical-subcortical intrinsic functional connectivity, and anxiety
Abend R, Ruiz S, Bajaj M, Harrewijn A, Linke J, Atlas L, Winkler A, Pine D. Threat imminence reveals links among unfolding of anticipatory physiological response, cortical-subcortical intrinsic functional connectivity, and anxiety. Neurobiology Of Stress 2022, 16: 100428. PMID: 35036479, PMCID: PMC8749274, DOI: 10.1016/j.ynstr.2022.100428.Peer-Reviewed Original ResearchThreat imminenceAnticipatory physiological responsesAnxiety effectsPathological anxietyResting-state functional connectivity dataNon-painful thermal stimulationThreat-anticipation taskAnticipation of threatVentromedial prefrontal cortexIntrinsic functional connectivityFunctional connectivity dataDefensive responsesCortical-subcortical circuitsBasic neuroscience researchAnticipatory respondingPhysiological respondingDefensive respondingFear responsesMultivariate network analysisIntrinsic connectivityPrefrontal cortexAnxiety patientsNeuroscience researchPhysiological responsesFunctional connectivity
2019
Anticipatory Threat Responding: Associations With Anxiety, Development, and Brain Structure
Abend R, Gold A, Britton J, Michalska K, Shechner T, Sachs J, Winkler A, Leibenluft E, Averbeck B, Pine D. Anticipatory Threat Responding: Associations With Anxiety, Development, and Brain Structure. Biological Psychiatry 2019, 87: 916-925. PMID: 31955915, PMCID: PMC7211142, DOI: 10.1016/j.biopsych.2019.11.006.Peer-Reviewed Original ResearchConceptsSkin conductance responsesConductance responsesBrain structuresThreat conditioningPathological anxietyComparison subjectsPsychophysiological responsesLarger patient samplesPrefrontal cortical thicknessHealthy comparison subjectsStructural magnetic resonance imaging (MRI) dataThreat stimuliAnticipatory respondingExtinction paradigmStimulus typeMagnetic resonance imaging dataWide age rangeCortical thicknessPatientsNeurodevelopmental changesAnticipatory responsesTranslational advancesStructural brainAdult populationPatient samples