2020
Griffithsin Inhibits Nipah Virus Entry and Fusion and Can Protect Syrian Golden Hamsters From Lethal Nipah Virus Challenge
Lo MK, Spengler JR, Krumpe LRH, Welch SR, Chattopadhyay A, Harmon JR, Coleman-McCray JD, Scholte FEM, Hotard AL, Fuqua JL, Rose JK, Nichol ST, Palmer KE, O’Keefe B, Spiropoulou CF. Griffithsin Inhibits Nipah Virus Entry and Fusion and Can Protect Syrian Golden Hamsters From Lethal Nipah Virus Challenge. The Journal Of Infectious Diseases 2020, 221: s480-s492. PMID: 32037447, PMCID: PMC7199786, DOI: 10.1093/infdis/jiz630.Peer-Reviewed Original ResearchConceptsSyrian golden hamstersGolden hamstersSevere acute respiratory syndrome coronavirusHuman immunodeficiency virus-1Acute respiratory syndrome coronavirusHepatitis C virusPathogenic zoonotic paramyxovirusImmunodeficiency virus-1Japanese encephalitis virusProphylactic evaluationC virusVirus challengeNiV infectionFatal encephalitisRespiratory diseaseSignificant protectionEncephalitis virusAntiviral activityZoonotic paramyxovirusVirus entrySyncytium formationGreater potencyVirus 1Nipah virusBroad-spectrum activity
2013
Single-dose replication-defective VSV-based Nipah virus vaccines provide protection from lethal challenge in Syrian hamsters
Lo MK, Bird BH, Chattopadhyay A, Drew CP, Martin BE, Coleman JD, Rose JK, Nichol ST, Spiropoulou CF. Single-dose replication-defective VSV-based Nipah virus vaccines provide protection from lethal challenge in Syrian hamsters. Antiviral Research 2013, 101: 26-29. PMID: 24184127, PMCID: PMC3874889, DOI: 10.1016/j.antiviral.2013.10.012.Peer-Reviewed Original ResearchConceptsFatal human encephalitisSingle-dose protectionReplication-defective vesicular stomatitis virusSafety profileLethal challengeSingle doseVirus vaccineEnhanced safety profileHuman encephalitisVaccine vectorVesicular stomatitis virusSyrian hamstersNiV fusionNipah virusBat reservoirsStomatitis virusAttachment glycoproteinHamstersVirusEncephalitisVaccineDoseIdentification of a Region in the Stalk Domain of the Nipah Virus Receptor Binding Protein That Is Critical for Fusion Activation
Talekar A, DeVito I, Salah Z, Palmer SG, Chattopadhyay A, Rose JK, Xu R, Wilson IA, Moscona A, Porotto M. Identification of a Region in the Stalk Domain of the Nipah Virus Receptor Binding Protein That Is Critical for Fusion Activation. Journal Of Virology 2013, 87: 10980-10996. PMID: 23903846, PMCID: PMC3807285, DOI: 10.1128/jvi.01646-13.Peer-Reviewed Original ResearchConceptsNewcastle disease virusReceptor binding proteinParamyxovirus fusion activationStalk domainBinding proteinAvian Newcastle disease virusHost cellsViral envelope glycoproteinsFusion activationNiV FEnvelope glycoproteinReceptor binding regionsTarget cellsNipah virusSialic acid moietiesDisease virusFusion signalChimeric proteinMembrane fusionReceptorsGlobular domainFusion proteinAttachment proteinCellular membranesActivation