Honokiol regulates mitochondrial substrate utilization and cellular fatty acid metabolism in diabetic mice heart
Jayakumari N, Rajendran R, Sivasailam A, Parambil S, Reghuvaran A, Sreelatha H, Gopala S. Honokiol regulates mitochondrial substrate utilization and cellular fatty acid metabolism in diabetic mice heart. European Journal Of Pharmacology 2021, 896: 173918. PMID: 33529726, DOI: 10.1016/j.ejphar.2021.173918.Peer-Reviewed Original ResearchMeSH KeywordsAcetylationAMP-Activated Protein KinasesAnimalsAntioxidantsBiphenyl CompoundsCD36 AntigensDiabetes Mellitus, ExperimentalDiabetes Mellitus, Type 2Energy MetabolismFatty AcidsLignansMaleMice, Inbred C57BLMitochondria, HeartMyocytes, CardiacNF-E2-Related Factor 2Oxidative StressPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaPPAR alphaStreptozocinSuperoxide DismutaseConceptsComplex IFatty acid metabolismMitochondrial metabolic changesAcetylation/deacetylation mechanismCellular fatty acid metabolismFatty acid respirationAcid metabolismHonokiol treatmentMitochondrial substrate utilizationMouse cardiac mitochondriaCardiac mitochondriaType 2 diabetes mellitusNuclear transcription factorPeroxisome proliferator-activated receptor αProtein functionProliferator-activated receptor αAcetylated proteinsTranscription factorsDiabetic mouse heartsCardiac mitochondrial dysfunctionCardiac mitochondrial functionDeacetylation mechanismExpression of clusterMitochondrial functionMitochondrial dysfunction