Are nitric oxide-mediated protein modifications of functional significance in diabetic heart? ye'S, -NO’, wh‘Y-NO’t?
Jayakumari N, Reghuvaran A, Rajendran R, Pillai V, Karunakaran J, Sreelatha H, Gopala S. Are nitric oxide-mediated protein modifications of functional significance in diabetic heart? ye'S, -NO’, wh‘Y-NO’t? Nitric Oxide 2014, 43: 35-44. PMID: 25153035, DOI: 10.1016/j.niox.2014.08.002.Peer-Reviewed Original ResearchConceptsProtein modificationReactive oxygen speciesS-nitrosylationNitric oxide-mediated protein modificationsPotential S-nitrosylation sitesTyrosine nitrationCysteine S-nitrosylationBiotin switch assaySpecific cysteine residuesS-nitrosylation sitesEmbryonic heart developmentSwitch assayHeart developmentCysteine residuesCytosolic proteinsProtein degradationNitrogen-derived oxidantsFunctional importanceCovalent modificationAmino acidsProteinFunctional significanceNormal physiologyCatalytic activityPathological relevance