2014
STEVOR Is a Plasmodium falciparum Erythrocyte Binding Protein that Mediates Merozoite Invasion and Rosetting
Niang M, Bei AK, Madnani KG, Pelly S, Dankwa S, Kanjee U, Gunalan K, Amaladoss A, Yeo KP, Bob NS, Malleret B, Duraisingh MT, Preiser PR. STEVOR Is a Plasmodium falciparum Erythrocyte Binding Protein that Mediates Merozoite Invasion and Rosetting. Cell Host & Microbe 2014, 16: 81-93. PMID: 25011110, PMCID: PMC4382205, DOI: 10.1016/j.chom.2014.06.004.Peer-Reviewed Original ResearchConceptsMerozoite invasionFalciparum erythrocyte membrane protein 1P. falciparum erythrocyte membrane protein 1Erythrocyte membrane protein 1Variant surface antigensErythrocyte binding proteinInfected erythrocyte surfaceErythrocyte-binding proteinsMembrane protein 1STEVOR expressionMalaria pathogenesisRed blood cell surfaceImmune evasionSurface antigenUninfected RBCsBlood cell surfaceGlycophorin CInfected RBCsErythrocyte surfaceParasite infectionProtein 1Invasive merozoitesForm rosettesSTEVORSchizont stage
2013
Plasmodium falciparum Merozoite Surface Antigen, PfRH5, Elicits Detectable Levels of Invasion-Inhibiting Antibodies in Humans
Patel SD, Ahouidi AD, Bei AK, Dieye TN, Mboup S, Harrison SC, Duraisingh MT. Plasmodium falciparum Merozoite Surface Antigen, PfRH5, Elicits Detectable Levels of Invasion-Inhibiting Antibodies in Humans. The Journal Of Infectious Diseases 2013, 208: 1679-1687. PMID: 23904294, PMCID: PMC3805239, DOI: 10.1093/infdis/jit385.Peer-Reviewed Original ResearchConceptsMerozoite surface antigenSurface antigenPlasmodium falciparum merozoite surface antigenMulti-subunit vaccineMillions of infectionsIntracellular protozoan parasiteInvasion inhibition assaysSubstantial morbidityClinical isolatesP. falciparumBlood stagesPlasmodium falciparumNatural infectionAntibodiesPfRH5Protozoan parasiteDetectable levelsInhibition assaysInfectionAntigenFalciparumRecombinant formMorbidityLaboratory strainsVaccine
2010
Functional diversification between two related Plasmodium falciparum merozoite invasion ligands is determined by changes in the cytoplasmic domain
Dvorin JD, Bei AK, Coleman BI, Duraisingh MT. Functional diversification between two related Plasmodium falciparum merozoite invasion ligands is determined by changes in the cytoplasmic domain. Molecular Microbiology 2010, 75: 990-1006. PMID: 20487292, PMCID: PMC3627358, DOI: 10.1111/j.1365-2958.2009.07040.x.Peer-Reviewed Original ResearchConceptsCytoplasmic domainFunctional diversificationInvasion pathwaysMulti-gene familyDifferent erythrocyte receptorsAmino acid regionAlternative invasion pathwaysN-terminal amino acidsGenomic regionsProtein homologueTransmembrane domainTransmembrane regionPfRh proteinsErythrocyte receptorEfficient invasionAcid regionInvasive merozoitesHost erythrocytePfRh2bAmino acidsPfRh2aPathway utilizationApical surfaceInvasion ligandsEctodomain