2017
Genetic relatedness analysis reveals the cotransmission of genetically related Plasmodium falciparum parasites in Thiès, Senegal
Wong W, Griggs AD, Daniels RF, Schaffner SF, Ndiaye D, Bei AK, Deme AB, MacInnis B, Volkman SK, Hartl DL, Neafsey DE, Wirth DF. Genetic relatedness analysis reveals the cotransmission of genetically related Plasmodium falciparum parasites in Thiès, Senegal. Genome Medicine 2017, 9: 5. PMID: 28118860, PMCID: PMC5260019, DOI: 10.1186/s13073-017-0398-0.Peer-Reviewed Original ResearchConceptsPolygenomic infectionsRelatedness of strainsMalaria elimination activitiesPlasmodium falciparum parasitesPublic health interventionsEpidemiology modelFalciparum parasitesHealth interventionsDrug resistanceInfectionParasite populationsConclusionsOur findingsCotransmissionSuperinfection modelElimination activitiesTransmission intensityGenetic relatedness analysisGenetic profileInterventionParasitesMajor contributorPatientsPopulationSuperinfectionThiès
2014
Immune Characterization of Plasmodium falciparum Parasites with a Shared Genetic Signature in a Region of Decreasing Transmission
Bei AK, Diouf A, Miura K, Larremore DB, Ribacke U, Tullo G, Moss EL, Neafsey DE, Daniels RF, Zeituni AE, Nosamiefan I, Volkman SK, Ahouidi AD, Ndiaye D, Dieye T, Mboup S, Buckee CO, Long CA, Wirth DF. Immune Characterization of Plasmodium falciparum Parasites with a Shared Genetic Signature in a Region of Decreasing Transmission. Infection And Immunity 2014, 83: 276-285. PMID: 25368109, PMCID: PMC4288878, DOI: 10.1128/iai.01979-14.Peer-Reviewed Original ResearchConceptsQuantitative reverse transcription PCRCommon genetic signatureSurface antigenClinical isolatesVar genesPlasmodium falciparum parasite populationsVariant surface antigensPlasmodium falciparum parasitesParasite-infected erythrocytesImmune characterizationMajor variant surface antigenSpecific parasite genotypesReverse transcription-PCRImmune responseFalciparum parasitesImmune recognitionMalaria transmissionVar transcriptsInfected erythrocytesParasite growthParasite clonesTranscription-PCRAntibodiesParasite correlatesParasite genotypesAn Adjustable Gas-Mixing Device to Increase Feasibility of In Vitro Culture of Plasmodium falciparum Parasites in the Field
Bei AK, Patel SD, Volkman SK, Ahouidi AD, Ndiaye D, Mboup S, Wirth DF. An Adjustable Gas-Mixing Device to Increase Feasibility of In Vitro Culture of Plasmodium falciparum Parasites in the Field. PLOS ONE 2014, 9: e90928. PMID: 24603696, PMCID: PMC3946284, DOI: 10.1371/journal.pone.0090928.Peer-Reviewed Original Research
2012
Functional analysis of erythrocyte determinants of Plasmodium infection
Bei AK, Duraisingh MT. Functional analysis of erythrocyte determinants of Plasmodium infection. International Journal For Parasitology 2012, 42: 575-582. PMID: 22726752, PMCID: PMC3383627, DOI: 10.1016/j.ijpara.2012.03.006.Peer-Reviewed Original ResearchConceptsFunctional analysisErythrocyte determinantsObligate intracellular pathogensPlasmodium infectionTransgenic approachesHuman erythrocytes resultsNatural variationErythrocyte invasionIntracellular pathogensPlasmodium falciparum parasitesUnexplored frontierClinical manifestationsMalaria researchErythrocytes resultsFalciparum parasitesInvasionMalarial diseaseChemical biologicalInfectionErythrocytesParasitesPathogensDeterminantsRemodellingDiscovery
2009
Erythrocyte invasion profiles are associated with a common invasion ligand polymorphism in Senegalese isolates of Plasmodium falciparum
LANTOS PM, AHOUIDI AD, BEI AK, JENNINGS CV, SARR O, NDIR O, WIRTH DF, MBOUP S, DURAISINGH MT. Erythrocyte invasion profiles are associated with a common invasion ligand polymorphism in Senegalese isolates of Plasmodium falciparum. Parasitology 2009, 136: 1-9. PMID: 19126266, DOI: 10.1017/s0031182008005167.Peer-Reviewed Original ResearchConceptsErythrocyte receptorSialic acid-independent invasionBlood group O patientsDifferent erythrocyte receptorsGroup O patientsSenegalese isolatesParasite multiplication ratePlasmodium falciparum parasitesMultiple ligand-receptor interactionsO patientsFalciparum parasitesLarge sequence deletionsVariant expression levelParasite isolatesPlasmodium falciparumErythrocyte invasionSelectivity indexReceptorsExpression levelsMajor polymorphismsInvasionInvasion pathwaysPossible determinantsParasitesHuman erythrocytes