2014
MKK3 regulates mitochondrial biogenesis and mitophagy in sepsis-induced lung injury
Mannam P, Shinn AS, Srivastava A, Neamu RF, Walker WE, Bohanon M, Merkel J, Kang MJ, Dela Cruz CS, Ahasic AM, Pisani MA, Trentalange M, West AP, Shadel GS, Elias JA, Lee PJ. MKK3 regulates mitochondrial biogenesis and mitophagy in sepsis-induced lung injury. American Journal Of Physiology - Lung Cellular And Molecular Physiology 2014, 306: l604-l619. PMID: 24487387, PMCID: PMC3962628, DOI: 10.1152/ajplung.00272.2013.Peer-Reviewed Original ResearchConceptsSepsis-induced lung injuryPeripheral blood mononuclear cellsPrimary mouse lung endothelial cellsLethality of sepsisLevels of lungSystemic inflammatory responsePathogenesis of sepsisBlood mononuclear cellsCurrent medical careEffective therapeutic strategyRelevant animal modelsMitochondrial functionLung endothelial cellsNew diagnostic markersMitochondrial biogenesisAction of SIRT1Mouse lung endothelial cellsLung injurySeptic patientsNonseptic controlsMononuclear cellsSpecific therapyInflammatory responseSepsisTherapeutic strategies
2012
Distinct and replicable genetic risk factors for acute respiratory distress syndrome of pulmonary or extrapulmonary origin
Tejera P, Meyer NJ, Chen F, Feng R, Zhao Y, O'Mahony DS, Li L, Sheu CC, Zhai R, Wang Z, Su L, Bajwa E, Ahasic AM, Clardy PF, Gong MN, Frank AJ, Lanken PN, Thompson BT, Christie JD, Wurfel MM, O'Keefe GE, Christiani DC. Distinct and replicable genetic risk factors for acute respiratory distress syndrome of pulmonary or extrapulmonary origin. Journal Of Medical Genetics 2012, 49: 671. PMID: 23048207, PMCID: PMC3654537, DOI: 10.1136/jmedgenet-2012-100972.Peer-Reviewed Original ResearchConceptsAcute lung injuryALI/ARDSIndirect lung injuryRisk of ARDSRespiratory distress syndromeLung injuryExtrapulmonary causesDistress syndromeIndirect insultsSingle nucleotide polymorphismsStage IIAcute respiratory distress syndromeDevelopment of ARDSGenetic variantsGenetic risk factorsIll Caucasian patientsFunctional single nucleotide polymorphismsALI/Extrapulmonary injuryPulmonary sepsisPulmonary injuryExtrapulmonary originCaucasian patientsRisk factorsARDS