A placebo-controlled randomized clinical trial of amantadine hydrochloride for evaluating the functional improvement of patients following severe acute traumatic brain injury.
Shimia M, Iranmehr A, Valizadeh A, Mirzaei F, Namvar M, Rafiei E, Rahimi A, Khadivi A, Aeinfar K. A placebo-controlled randomized clinical trial of amantadine hydrochloride for evaluating the functional improvement of patients following severe acute traumatic brain injury. Journal Of Neurosurgical Sciences 2021, 67: 598-604. PMID: 34114429, DOI: 10.23736/s0390-5616.21.05266-8.Peer-Reviewed Original ResearchConceptsGlasgow Outcome ScaleDisability Rating ScaleTraumatic brain injurySevere TBI patientsAmantadine hydrochlorideTBI patientsBrain injuryFunctional improvementClinical trialsSevere acute traumatic brain injuryAcute traumatic brain injuryMean Glasgow Outcome ScaleSevere traumatic brain injuryFunctional ability improvementEffect of amantadineDopaminergic neurotransmitter systemWeeks of trialAmantadine groupPharmacologic optionsDopamine agonistsOutcome ScaleNeurotransmitter systemsOutcome measurementsPatientsRating Scale