2018
Immunosuppressive therapy in myelodysplastic syndromes: a borrowed therapy in search of the right place
Shallis RM, Chokr N, Stahl M, Pine AB, Zeidan AM. Immunosuppressive therapy in myelodysplastic syndromes: a borrowed therapy in search of the right place. Expert Review Of Hematology 2018, 11: 715-726. PMID: 30024293, DOI: 10.1080/17474086.2018.1503049.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsImmunosuppressive therapyMyelodysplastic syndromeImmune pathwaysManagement of MDSTreatment of MDSClonal hematopoietic stem cell disordersMeaningful clinical activityAdaptive immune pathwaysHematopoietic stem cell disordersStem cell disordersImmune dysregulationDisease coursePeripheral cytopeniasClinical benefitImmune activationTherapeutic optionsAplastic anemiaClinical activityHematologic diseasesCell disordersClinical experienceContinued clarificationLeukemic progressionTherapyPatients
2017
Immunotherapeutic Concepts to Target Acute Myeloid Leukemia: Focusing on the Role of Monoclonal Antibodies, Hypomethylating Agents and the Leukemic Microenvironment
Gbolahan OB, Zeidan AM, Stahl M, Abu Zaid M, Farag S, Paczesny S, Konig H. Immunotherapeutic Concepts to Target Acute Myeloid Leukemia: Focusing on the Role of Monoclonal Antibodies, Hypomethylating Agents and the Leukemic Microenvironment. International Journal Of Molecular Sciences 2017, 18: 1660. PMID: 28758974, PMCID: PMC5578050, DOI: 10.3390/ijms18081660.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsAnimalsAntineoplastic Agents, ImmunologicalHumansImmunotherapyLeukemia, Myeloid, AcuteTumor MicroenvironmentConceptsLeukemic microenvironmentAllogeneic stem cell transplantationLong-term disease controlAcute myeloid leukemia (AML) treatmentMonoclonal antibodiesIntensive chemotherapeutic protocolsImmune-based therapiesMajority of patientsOverall survival rateStem cell transplantationManagement of AMLAcute myeloid leukemiaElicit immune responsesMyeloid leukemia treatmentEarly phase studiesNovel treatment conceptsImmunotherapeutic interventionsMost patientsAML therapyImmunotherapeutic conceptsPoor outcomeCell transplantationToxic therapiesChemotherapeutic protocolsMyeloid leukemia
2014
Hepatocellular carcinoma: systemic therapies and future perspectives
Mikhail S, Cosgrove D, Zeidan A. Hepatocellular carcinoma: systemic therapies and future perspectives. Expert Review Of Anticancer Therapy 2014, 14: 1205-1218. PMID: 25199765, DOI: 10.1586/14737140.2014.949246.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsHepatitis C virus infectionC virus infectionIncidence of HCCMedian survival timeCommon primary malignancyCancer-related deathCommon solid cancersFuture therapeutic directionsUnresectable diseaseLiver transplantationLocoregional therapyPrimary malignancySurgical resectionSystemic therapyTreatment optionsSystemic optionsVirus infectionHepatocellular carcinomaSolid cancersSurvival timeMolecular pathogenesisTherapeutic directionsTherapyHCCPatients