2019
Myeloid disorders after autoimmune disease
Boddu P, Zeidan AM. Myeloid disorders after autoimmune disease. Best Practice & Research Clinical Haematology 2019, 32: 74-88. PMID: 30927978, PMCID: PMC6541412, DOI: 10.1016/j.beha.2019.02.002.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsArthritis, RheumatoidCyclophosphamideGenetic Predisposition to DiseaseHumansImmunosuppressive AgentsLeukemia, Myeloid, AcuteLupus Erythematosus, SystemicMitoxantroneMyelodysplastic SyndromesNeoplasms, Second PrimaryConceptsAutoimmune diseasesMyeloid neoplasmsTherapy exposureAnti-tumor necrosis factor-alpha inhibitorsNecrosis factor-alpha inhibitorsPlausible biologic mechanismsAnti-rheumatic drugsChronic immune stimulationSystemic lupus erythematosusBone marrow infiltrationMN developmentInflammatory bowel disordersAcute myeloid leukemiaAD typeDuration of exposureMN pathogenesisParaclinical featuresBowel disordersLupus erythematosusMarrow infiltrationLymphoproliferative disordersRheumatoid arthritisMultiple sclerosisMyelodysplastic syndromeExcess risk
2018
The genetic and molecular pathogenesis of myelodysplastic syndromes
Shallis RM, Ahmad R, Zeidan AM. The genetic and molecular pathogenesis of myelodysplastic syndromes. European Journal Of Haematology 2018, 101: 260-271. PMID: 29742289, DOI: 10.1111/ejh.13092.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsMolecular pathogenesisGene expression profilingSignal transduction elementsDevelopment of MDSHigh-throughput techniquesCohesin proteinsMyelodysplastic syndromeRNA splicingDNA methylationTranscription factorsDNA repairMolecular basisExpression profilingMalignant myeloid disordersBone marrow microenvironmentGenetic materialClonal architectureSuch mutationsTransduction elementsInflammatory bone marrow microenvironmentMarrow microenvironmentImportant substrateGenetic mutationsDiverse groupPathophysiology of MDS