2020
The relationship between H19 and parameters of ovarian reserve
Xia X, Burn MS, Chen Y, Karakaya C, Kallen A. The relationship between H19 and parameters of ovarian reserve. Reproductive Biology And Endocrinology 2020, 18: 46. PMID: 32404103, PMCID: PMC7218823, DOI: 10.1186/s12958-020-00578-z.Peer-Reviewed Original ResearchConceptsOvarian reserveDecreased ovarian reserveOocyte retrievalH19 expressionInfertility evaluationCumulus cellsTransvaginal oocyte retrievalDiminished ovarian reserveAnti-Mullerian hormoneDownregulation of H19H19 expression levelsGazi University SchoolParticipantsA totalAMH levelsSerum AMHIVF patientsOocyte yieldLow respondersBlood samplesNovel biomarkersExpression levelsFurther studiesPatientsUniversity SchoolH19
2019
Translational activation of maternally derived mRNAs in oocytes and early embryos and the role of embryonic poly(A) binding protein (EPAB)
Esencan E, Kallen A, Zhang M, Seli E. Translational activation of maternally derived mRNAs in oocytes and early embryos and the role of embryonic poly(A) binding protein (EPAB). Biology Of Reproduction 2019, 100: 1147-1157. PMID: 30806655, PMCID: PMC8127035, DOI: 10.1093/biolre/ioz034.Peer-Reviewed Original ResearchConceptsTranslational activationBinding proteinSpecific protein complexesTranslation of mRNAsOocyte maturationCis-acting sequencesEarly embryo developmentProtein complexesXenopus modelEarly embryosKey regulatorGene expressionMolecular mechanismsEmbryo developmentTargeted disruptionMechanistic detailsProteinEarly developmentMRNAMice resultsKey mechanismOocytesActivationMaturationTranscription
2018
Untapped Reserves: Controlling Primordial Follicle Growth Activation
Kallen A, Polotsky AJ, Johnson J. Untapped Reserves: Controlling Primordial Follicle Growth Activation. Trends In Molecular Medicine 2018, 24: 319-331. PMID: 29452791, PMCID: PMC6482944, DOI: 10.1016/j.molmed.2018.01.008.Peer-Reviewed Original ResearchConceptsPrimordial follicle growth activationDormant primordial folliclesRecovery of eggsCare treatmentHuman ovaryCommon causeLive birthsPrimordial folliclesOocyte qualityOvarian folliclesHealthy offspringGrowth activationReproductive technologiesFolliclesBirthHigh-quality eggsActivationEpigenetic strategiesInfertilityWomen