Elastic, silk‐cardiac extracellular matrix hydrogels exhibit time‐dependent stiffening that modulates cardiac fibroblast response
Stoppel W, Gao A, Greaney A, Partlow B, Bretherton R, Kaplan D, Black L. Elastic, silk‐cardiac extracellular matrix hydrogels exhibit time‐dependent stiffening that modulates cardiac fibroblast response. Journal Of Biomedical Materials Research Part A 2016, 104: 3058-3072. PMID: 27480328, PMCID: PMC5805141, DOI: 10.1002/jbm.a.35850.Peer-Reviewed Original ResearchConceptsExtracellular matrix hydrogelTissue-derived extracellular matrixEndothelial cell ingrowthSilk hydrogelsMechanical propertiesCell ingrowthWeeks in vivoHydrogel stiffeningMatrix hydrogelHydrogelsFunctional cardiac repairStiffeningFocal adhesion proteinsCardiac fibroblastsExpression of integrinsCardiac repairHeart failureProgression to heart failureTissue in vitroAdhesion proteinsCell growthExtracellular matrix