2003
The hedgehog pathway and developmental disorders
Bale A. The hedgehog pathway and developmental disorders. 2003, 258-272. DOI: 10.4324/9780203450420-14.Peer-Reviewed Original ResearchHedgehog signal transduction pathwaySignal transduction pathwaysDrosophila melanogasterDevelopmental biologistsN-terminal fragmentTransduction pathwaysActive N-terminal fragmentFruit flyTissue specificityAutocatalytic cleavageHuman diseasesWnt pathwayHedgehog pathwayDownstream membersPathwayHedgehogTwo-hit modelVariety of tumorsMutationsGermline mutationsAutosomal dominant disorderBirth defectsMelanogasterDominant disorderEmbryogenesis
2002
HEDGEHOG SIGNALING AND HUMAN DISEASE
Bale AE. HEDGEHOG SIGNALING AND HUMAN DISEASE. Annual Review Of Genomics And Human Genetics 2002, 3: 47-65. PMID: 12142354, DOI: 10.1146/annurev.genom.3.022502.103031.Peer-Reviewed Original ResearchConceptsEarly Drosophila developmentHedgehog pathwayDrosophila developmentDevelopmental genesDrosophila melanogasterHuman embryogenesisHedgehog signalingDevelopmental pathwaysGenetic studiesHuman diseasesCell growthEmbryogenesisPathwayKey roleMelanogasterVertebratesImportant roleCentral nervous systemAxial skeletonGenesNervous systemSignalingMutationsDifferentiationRegulation
2001
The hedgehog pathway and basal cell carcinomas
Bale A, Yu K. The hedgehog pathway and basal cell carcinomas. Human Molecular Genetics 2001, 10: 757-762. PMID: 11257109, DOI: 10.1093/hmg/10.7.757.Peer-Reviewed Original ResearchConceptsGenetic studiesHereditary basal cell carcinomasDrosophila genesEmbryonic patterningDevelopmental genesDrosophila melanogasterCell fateHuman homologFruit flyHuman congenital anomaliesBiochemical pathwaysRational medical therapyDevelopmental pathwaysHedgehog pathwayGenesCell growthTumor formationPathwayGorlin syndromeBasal cell carcinomaMutationsHereditary diseaseBirth defectsDrosophilaMelanogaster