2014
Dual role for Fcγ receptors in host defense and disease in Borrelia burgdorferi-infected mice
Belperron AA, Liu N, Booth CJ, Bockenstedt LK. Dual role for Fcγ receptors in host defense and disease in Borrelia burgdorferi-infected mice. Frontiers In Cellular And Infection Microbiology 2014, 4: 75. PMID: 24967215, PMCID: PMC4052197, DOI: 10.3389/fcimb.2014.00075.Peer-Reviewed Original ResearchConceptsInnate immune cellsWild-type miceB. burgdorferi infectionB. burgdorferi-infected miceBurgdorferi-infected miceImmune cellsBurgdorferi infectionType micePathogen burdenHost defenseFc receptor common gamma chainIgG-mediated clearanceC-reactive proteinBorrelia burgdorferiToll-Like Receptor InteractionsSingle knockout miceCommon gamma chainAcute phaseInfected jointsArthritis severityMolecule MyD88Inflammatory cytokinesInflammatory pathwaysIL-1betaReactive proteinWhat ticks do under your skin: two-photon intravital imaging of Ixodes scapularis feeding in the presence of the lyme disease spirochete.
Bockenstedt LK, Gonzalez D, Mao J, Li M, Belperron AA, Haberman A. What ticks do under your skin: two-photon intravital imaging of Ixodes scapularis feeding in the presence of the lyme disease spirochete. The Yale Journal Of Biology And Medicine 2014, 87: 3-13. PMID: 24600332, PMCID: PMC3941458.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsArachnid VectorsBorrelia burgdorferiFeeding BehaviorGreen Fluorescent ProteinsHost-Parasite InteractionsHost-Pathogen InteractionsIxodesLyme DiseaseMiceMice, Inbred BALB CMice, Inbred C57BLMice, KnockoutMicroscopy, ConfocalMicroscopy, Electron, ScanningMicroscopy, Fluorescence, MultiphotonNymphSkinTick InfestationsTime Factors
2012
Spirochete antigens persist near cartilage after murine Lyme borreliosis therapy
Bockenstedt LK, Gonzalez DG, Haberman AM, Belperron AA. Spirochete antigens persist near cartilage after murine Lyme borreliosis therapy. Journal Of Clinical Investigation 2012, 122: 2652-2660. PMID: 22728937, PMCID: PMC3386809, DOI: 10.1172/jci58813.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnti-Bacterial AgentsAntigens, BacterialArthritis, InfectiousBacterial LoadBorrelia burgdorferiCartilageCeftriaxoneDoxycyclineEar, ExternalFemaleFluorescence Recovery After PhotobleachingGreen Fluorescent ProteinsJoint CapsuleLyme DiseaseMiceMice, Inbred C3HMice, Inbred C57BLMice, KnockoutMicroscopy, Fluorescence, MultiphotonMyeloid Differentiation Factor 88PatellaRecombinant ProteinsConceptsNaive miceAntibiotic treatmentIntravital microscopyAntibiotic-refractory Lyme arthritisLyme diseaseTNF-α productionBorrelia burgdorferi antigensB. burgdorferi antigensSpirochete antigenTLR responsivenessInflammatory arthritisAntibiotic therapyLyme arthritisWT miceMusculoskeletal symptomsAntigens persistSlow resolutionImmunodeficient miceMouse modelTissue transplantsPathogen burdenSpirochete DNAInfectious spirochetesLyme borreliosisMice
2005
Infection-Induced Marginal Zone B Cell Production of Borrelia hermsii-Specific Antibody Is Impaired in the Absence of CD1d
Belperron AA, Dailey CM, Bockenstedt LK. Infection-Induced Marginal Zone B Cell Production of Borrelia hermsii-Specific Antibody Is Impaired in the Absence of CD1d. The Journal Of Immunology 2005, 174: 5681-5686. PMID: 15843569, DOI: 10.4049/jimmunol.174.9.5681.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, BacterialAntibody SpecificityAntigens, CD1Antigens, CD1dB-Lymphocyte SubsetsBorreliaBorrelia InfectionsDNA, BacterialGerminal CenterImmune SeraImmunity, InnateImmunization, PassiveImmunoglobulin MLymphocyte ActivationLymphocyte DepletionMiceMice, Inbred C57BLMice, KnockoutConceptsMZB cellsActivation markersPathogen burdenMouse serumAbsence of CD1dBlood-borne AgsCD1d-deficient micePathogen-specific IgMActivation marker expressionMarginal zone B cellsT cell helpImmune mouse serumWild-type miceCritical host defenseB cell productionB. hermsiiCD1d expressionSerum levelsCell helpPassive transferSpirochete burdenAb productionSpirochete Borrelia burgdorferiB cellsCell activation
2000
Cutting Edge: CD1d Deficiency Impairs Murine Host Defense Against the Spirochete, Borrelia burgdorferi
Kumar H, Belperron A, Barthold S, Bockenstedt L. Cutting Edge: CD1d Deficiency Impairs Murine Host Defense Against the Spirochete, Borrelia burgdorferi. The Journal Of Immunology 2000, 165: 4797-4801. PMID: 11046002, DOI: 10.4049/jimmunol.165.9.4797.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, BacterialAntigens, BacterialAntigens, CD1Antigens, CD1dAntigens, SurfaceBacterial Outer Membrane ProteinsBacterial VaccinesBorrelia burgdorferi GroupDNA, BacterialGenetic Predisposition to DiseaseImmunity, InnateImmunoglobulin GLipoproteinsLyme DiseaseLyme Disease VaccinesMiceMice, Inbred C3HMice, Inbred C57BLMice, KnockoutUrinary BladderConceptsLipid AgsHost defenseCD1d-deficient miceDisease-susceptible miceMurine host defenseRole of CD1dImpair host resistanceBorrelia burgdorferiSusceptible mouse strainsControl miceT cellsCD1 moleculesSpirochete DNADisease profileMouse strainsMiceLyme disease spirocheteInfectionSpirochetesBurgdorferiHost resistancePathogensArthritisCD1dEnhanced production