Toxoplasma gondii: generation of novel truncation mutations in the linker domain of dihydrofolate reductase–thymidylate synthase
Belperron AA, Fox BA, O’Neil R, Peaslee KA, Horii T, Anderson AC, Bzik DJ. Toxoplasma gondii: generation of novel truncation mutations in the linker domain of dihydrofolate reductase–thymidylate synthase. Experimental Parasitology 2004, 106: 179-182. PMID: 15172226, DOI: 10.1016/j.exppara.2004.03.002.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsAntiprotozoal AgentsBlotting, WesternDrug ResistanceHumansModels, GeneticMolecular Sequence DataMultienzyme ComplexesMutagenesis, InsertionalMutationPoint MutationPolymerase Chain ReactionPyrimethamineRestriction MappingSequence AlignmentTetrahydrofolate DehydrogenaseThymidylate SynthaseToxoplasmaTransfectionConceptsHigh-level pyrimethamine resistanceToxoplasma gondiiPyrimethamine resistanceNovel truncation mutationTruncation mutations