2009
The Caspase 1 Inflammasome Is Not Required for Control of Murine Lyme Borreliosis
Liu N, Belperron AA, Booth CJ, Bockenstedt LK. The Caspase 1 Inflammasome Is Not Required for Control of Murine Lyme Borreliosis. Infection And Immunity 2009, 77: 3320-3327. PMID: 19487481, PMCID: PMC2715671, DOI: 10.1128/iai.00100-09.Peer-Reviewed Original ResearchConceptsCaspase-1 inflammasomeCaspase-1Immune responseHost defenseLyme borreliosisToll-like receptor-mediated responsesDay 14 postinfectionPrevalence of arthritisT cell responsesApoptosis-associated speck-like proteinMild transient elevationBorrelia burgdorferiMurine Lyme borreliosisReceptor-mediated responsesCaspase-1 deficiencyC-terminal caspase recruitment domainSpeck-like proteinAbility of macrophagesEnzyme caspase-1IL-18Humoral immunityInterleukin-1betaTransient elevationPathogen burdenInflammasome
2003
Humoral Immunity Reflects Altered T Helper Cell Bias in Borrelia burgdorferi-Infected γδ T-Cell-Deficient Mice
Bockenstedt LK, Shanafelt MC, Belperron A, Mao J, Barthold SW. Humoral Immunity Reflects Altered T Helper Cell Bias in Borrelia burgdorferi-Infected γδ T-Cell-Deficient Mice. Infection And Immunity 2003, 71: 2938-2940. PMID: 12704174, PMCID: PMC153287, DOI: 10.1128/iai.71.5.2938-2940.2003.Peer-Reviewed Original ResearchConceptsΓδ T-cell-deficient miceT cell-deficient miceGamma delta T cellsGamma delta T-cell functionGamma delta TBorrelia burgdorferiDelta T cellsMurine Lyme borreliosisT cell functionHumoral immunityHumoral responseAntibody isotypesT cellsLyme borreliosisCell biasDisease susceptibilityArthropod transmissionBurgdorferi