2019
Molecular signatures of multiple myeloma progression through single cell RNA-Seq
Jang J, Li Y, Mitra A, Bi L, Abyzov A, van Wijnen A, Baughn L, Van Ness B, Rajkumar V, Kumar S, Jen J. Molecular signatures of multiple myeloma progression through single cell RNA-Seq. Blood Cancer Journal 2019, 9: 2. PMID: 30607001, PMCID: PMC6318319, DOI: 10.1038/s41408-018-0160-x.Peer-Reviewed Original ResearchConceptsMM patientsMultiple myelomaPoor overall survivalCD138-positive cellsBone marrow aspirateMultiple myeloma progressionSingle-cell RNA-seqMGUS patientsGene expression signaturesOverall survivalMM progressionDisease progressionMyeloma progressionPatient prognosisTreatment stratificationMarrow aspiratesPlasma cellsPositive cellsPatientsL4 groupGene signatureLow expressionExpression signaturesMolecular pathwaysProgression
2016
Colorectal Cancer with Residual Polyp of Origin: A Model of Malignant Transformation
Druliner B, Rashtak S, Ruan X, Bae T, Vasmatzis N, O’Brien D, Johnson R, Felmlee-Devine D, Washechek-Aletto J, Basu N, Liu H, Smyrk T, Abyzov A, Boardman L. Colorectal Cancer with Residual Polyp of Origin: A Model of Malignant Transformation. Translational Oncology 2016, 9: 280-286. PMID: 27567950, PMCID: PMC4941582, DOI: 10.1016/j.tranon.2016.06.002.Peer-Reviewed Original ResearchColorectal cancerResidual polypBiopsy-proven colorectal cancerEquivalent hazard ratiosEarly-stage diseaseSame disease stageRemnant polypsHazard ratioOverall survivalCancer Genome AtlasClinical coursePathologic characteristicsDisease stageMayo ClinicAdenomatous polypsColorectal carcinogenesisMalignant transformationCarcinoma transitionPolypsGenome AtlasGene expression profilesGenomic profilesWhole-genome sequencingCancerAge