2011
Rationale and design of the INFUSE-AMI study: A 2 × 2 factorial, randomized, multicenter, single-blind evaluation of intracoronary abciximab infusion and aspiration thrombectomy in patients undergoing percutaneous coronary intervention for anterior ST-segment elevation myocardial infarction
Gibson CM, Maehara A, Lansky AJ, Wohrle J, Stuckey T, Dave R, Cox D, Grines C, Dudek D, Steg G, Parise H, Wolff SD, Cristea E, Stone GW. Rationale and design of the INFUSE-AMI study: A 2 × 2 factorial, randomized, multicenter, single-blind evaluation of intracoronary abciximab infusion and aspiration thrombectomy in patients undergoing percutaneous coronary intervention for anterior ST-segment elevation myocardial infarction. American Heart Journal 2011, 161: 478-486.e7. PMID: 21392601, DOI: 10.1016/j.ahj.2010.10.006.Peer-Reviewed Original ResearchMeSH KeywordsAbciximabAngioplasty, Balloon, CoronaryAntibodies, MonoclonalAntithrombinsCoronary OcclusionCoronary ThrombosisEndpoint DeterminationHirudinsHumansImmunoglobulin Fab FragmentsInfusions, Intra-ArterialMagnetic Resonance Imaging, CineMyocardial InfarctionPatient SelectionPeptide FragmentsPlatelet Aggregation InhibitorsRecombinant ProteinsResearch DesignThrombectomyConceptsPrimary percutaneous coronary interventionST-elevation myocardial infarctionPrimary PCIAnterior ST-elevation myocardial infarctionExport aspiration catheterPercutaneous coronary interventionLocal infusionThrombus aspirationInfarct sizeINFUSE-AMIEnd pointCoronary interventionAspiration catheterMyocardial infarctionInfusion catheterAnterior ST-segment elevation myocardial infarctionST-segment elevation myocardial infarctionSingle-blind randomized studyCardiac magnetic resonance imagingMyocardial infarction 0Mid-left anteriorPrimary end pointSafety end pointSecondary end pointsST-segment resolution
2002
A trial comparing rheolytic thrombectomy with intracoronary urokinase for coronary and vein graft thrombus (the Vein Graft AngioJet Study [VeGAS 2])
Kuntz RE, Baim DS, Cohen DJ, Popma JJ, Carrozza JP, Sharma S, McCormick DJ, Schmidt DA, Lansky AJ, Ho KK, Dandreo KJ, Setum CM, Ramee SR, Investigators V. A trial comparing rheolytic thrombectomy with intracoronary urokinase for coronary and vein graft thrombus (the Vein Graft AngioJet Study [VeGAS 2]). The American Journal Of Cardiology 2002, 89: 326-330. PMID: 11809436, DOI: 10.1016/s0002-9149(01)02235-4.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAngioplasty, Balloon, CoronaryCoronary AngiographyCoronary ThrombosisDisease-Free SurvivalFemaleFibrinolytic AgentsGraft Occlusion, VascularHemorheologyHumansInfusions, Intra-ArterialMaleMiddle AgedThrombectomyTreatment OutcomeUnited StatesUrokinase-Type Plasminogen Activator
2000
Vascular remodeling and the local delivery of cytochalasin B after coronary angioplasty in humans
Lehmann K, Popma J, Werner J, Lansky A, Wilensky R. Vascular remodeling and the local delivery of cytochalasin B after coronary angioplasty in humans. Journal Of The American College Of Cardiology 2000, 35: 583-591. PMID: 10716458, DOI: 10.1016/s0735-1097(99)00603-8.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAngioplasty, Balloon, CoronaryCatheterization, PeripheralCoronary AngiographyCoronary DiseaseCoronary VesselsCytochalasin BDrug Delivery SystemsElectrocardiographyFeasibility StudiesFemaleHumansInfusions, Intra-ArterialMaleMiddle AgedMyocardial RevascularizationSafetyTreatment OutcomeConceptsCoronary angioplastyLocal deliveryVascular remodelingMinimal stenosis diameterSuccessful balloon angioplastyCombined end pointActive drug groupSuccessful coronary angioplastyLate lumen lossCytochalasin BSystemic drug administrationWarrants further studyInadequate dosingPlacebo groupClinical restenosisPharmacologic preventionAngioplasty siteClinical outcomesBalloon angioplastyLumen lossDrug groupsArterial constrictionElectrocardiographic variablesStenosis diameterAtherosclerotic plaques