2017
Confronting system barriers for ST- elevation MI in low and middle income countries with a focus on India
Mehta S, Granger C, Grines CL, Jacobs A, Henry TD, Rokos I, Lansky A, Baumbach A, Botelho R, Ferre A, Yepes I, Salwan R, Dalal J, Makkar J, Bhalla N, Mishra S, Vijan V, Hiremath S. Confronting system barriers for ST- elevation MI in low and middle income countries with a focus on India. Indian Heart Journal 2017, 70: 185-190. PMID: 29455776, PMCID: PMC5903067, DOI: 10.1016/j.ihj.2017.06.020.Peer-Reviewed Original ResearchReducing system delays in treatment of ST elevation myocardial infarction and confronting the challenges of late presentation in low and middle-income countries
Mehta S, Granger CB, Henry TD, Grines CL, Lansky A, Rokos I, Botelho R, Baumbach A, Mishra S, Cheem TH, Tresukosol D, Zambahari R, Ferré A, Castillo M. Reducing system delays in treatment of ST elevation myocardial infarction and confronting the challenges of late presentation in low and middle-income countries. Indian Heart Journal 2017, 69: s1-s5. PMID: 28400032, PMCID: PMC5388017, DOI: 10.1016/j.ihj.2016.12.020.Peer-Reviewed Original Research
2015
Impact of Bleeding and Bivalirudin Therapy on Mortality Risk in Women Undergoing Percutaneous Coronary Intervention (from the REPLACE-2, ACUITY, and HORIZONS-AMI Trials)
Ng VG, Baumbach A, Grinfeld L, Lincoff AM, Mehran R, Stone GW, Lansky AJ. Impact of Bleeding and Bivalirudin Therapy on Mortality Risk in Women Undergoing Percutaneous Coronary Intervention (from the REPLACE-2, ACUITY, and HORIZONS-AMI Trials). The American Journal Of Cardiology 2015, 117: 186-191. PMID: 26704028, DOI: 10.1016/j.amjcard.2015.10.029.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionStrong independent predictorMajor bleedingMortality rateBivalirudin therapyCoronary interventionIndependent predictorsFemale genderGlycoprotein IIb/IIIa inhibitor treatmentST-segment elevation myocardial infarctionNon-coronary artery bypassPatient-level pooled analysisImpact of bleedingMajor bleeding ratesPronounced clinical benefitOutcomes of patientsAcute coronary syndromeCohort of patientsElevation myocardial infarctionArtery bypassCoronary syndromeMultivariate adjustmentStandard therapyClinical benefitPooled analysis
2014
Implications of ventricular arrhythmia “bursts” with normal epicardial flow, myocardial blush, and ST-segment recovery in anterior ST-elevation myocardial infarction reperfusion: A biosignature of direct myocellular injury “downstream of downstream”
Majidi M, Kosinski AS, Al-Khatib SM, Smolders L, Cristea E, Lansky AJ, Stone GW, Mehran R, Gibbons RJ, Crijns HJ, Wellens HJ, Gorgels AP, Krucoff MW. Implications of ventricular arrhythmia “bursts” with normal epicardial flow, myocardial blush, and ST-segment recovery in anterior ST-elevation myocardial infarction reperfusion: A biosignature of direct myocellular injury “downstream of downstream”. European Heart Journal Acute Cardiovascular Care 2014, 4: 51-59. PMID: 25063574, DOI: 10.1177/2048872614532414.Peer-Reviewed Original ResearchConceptsST-segment recoveryMyocardial blush gradeST-segment elevation myocardial infarctionNormal epicardial flowTIMI 3 flowPercutaneous coronary interventionEpicardial flowLarger ISOptimal reperfusionVentricular arrhythmiasMyocellular injuryFinal TIMI 3 flowMyocardial Infarction 3 flowAnterior STEMI patientsElevation myocardial infarctionReperfusion ventricular arrhythmiasInfarct size assessmentMyocardial infarction reperfusionContinuous ECG monitoringMBG 2/3Myocardial ISBlush gradeSTEMI patientsCoronary interventionMyocardial reperfusionImpact of Nonculprit Vessel Myocardial Perfusion on Outcomes of Patients Undergoing Percutaneous Coronary Intervention for Acute Coronary Syndromes Analysis From the ACUITY Trial (Acute Catheterization and Urgent Intervention Triage Strategy)
Lansky AJ, Ng VG, Meller S, Xu K, Fahy M, Feit F, Ohman EM, White HD, Mehran R, Bertrand ME, Desmet W, Hamon M, Stone GW. Impact of Nonculprit Vessel Myocardial Perfusion on Outcomes of Patients Undergoing Percutaneous Coronary Intervention for Acute Coronary Syndromes Analysis From the ACUITY Trial (Acute Catheterization and Urgent Intervention Triage Strategy). JACC Cardiovascular Interventions 2014, 7: 266-275. PMID: 24650400, DOI: 10.1016/j.jcin.2013.08.016.Peer-Reviewed Original ResearchMeSH KeywordsAcute Coronary SyndromeAgedCardiac CatheterizationCoronary AngiographyCoronary CirculationDouble-Blind MethodElectrocardiographyEmergenciesFemaleFollow-Up StudiesHumansMaleMiddle AgedMyocardial Perfusion ImagingPercutaneous Coronary InterventionPericardiumPractice Guidelines as TopicPrognosisProspective StudiesSurvival RateTriageUnited StatesConceptsPercutaneous coronary interventionMyocardial blush gradeNSTE-ACS patientsMBG 0/1Myocardial perfusionACUITY trialNonculprit vesselsCulprit vesselCoronary interventionSegment elevation acute coronary syndrome patientsST-segment elevation myocardial infarction (STEMI) patientsElevation acute coronary syndrome patientsOutcomes of PCIAcute Coronary Syndromes AnalysisTIMI flow grade 3Worse baseline clinical characteristicsAcute coronary syndrome patientsElevation myocardial infarction patientsLong-term mortality ratesInfarct-related vesselBaseline clinical characteristicsOutcomes of patientsCoronary syndrome patientsRisk-stratify patientsMyocardial infarction patientsEsc
Meier P, Lansky AJ, Baumbach A. Esc. Acta Cardiologica 2014, 69: 100-108. PMID: 24640527, DOI: 10.1080/ac.69.1.3011351.Peer-Reviewed Original ResearchMeSH KeywordsAcute Coronary SyndromeDeath, Sudden, CardiacElectrocardiographyHumansMonitoring, PhysiologicMyocardial InfarctionOutcome Assessment, Health CarePercutaneous Coronary InterventionPlatelet Aggregation InhibitorsTime-to-TreatmentTomography, Optical CoherenceUltrasonography, InterventionalConceptsST-elevation myocardial infarctionAcute coronary syndromeCardiac arrestUnstable coronary artery plaqueRecent therapeutic progressElevation myocardial infarctionNovel antiplatelet agentsCoronary artery plaquesSudden cardiac arrestCommon underlying causeACS mortalityElevation infarctionCoronary syndromeUnstable anginaAntiplatelet agentsArtery plaquesMyocardial infarctionTherapeutic progressUnderlying causeInfarctionArrestAnginaCangrelorPrasugrelTicagrelor
2013
Relation Between Coronary Calcium and Major Bleeding After Percutaneous Coronary Intervention in Acute Coronary Syndromes (from the Acute Catheterization and Urgent Intervention Triage Strategy and Harmonizing Outcomes With Revascularization and Stents in Acute Myocardial Infarction Trials)
Généreux P, Madhavan MV, Mintz GS, Maehara A, Kirtane AJ, Palmerini T, Tarigopula M, McAndrew T, Lansky AJ, Mehran R, Brener SJ, Stone GW. Relation Between Coronary Calcium and Major Bleeding After Percutaneous Coronary Intervention in Acute Coronary Syndromes (from the Acute Catheterization and Urgent Intervention Triage Strategy and Harmonizing Outcomes With Revascularization and Stents in Acute Myocardial Infarction Trials). The American Journal Of Cardiology 2013, 113: 930-935. PMID: 24440325, DOI: 10.1016/j.amjcard.2013.11.053.Peer-Reviewed Original ResearchMeSH KeywordsAgedCalciumCardiac CatheterizationCoronary AngiographyCoronary VesselsDrug-Eluting StentsElectrocardiographyFemaleFollow-Up StudiesHumansIncidenceMaleMiddle AgedMyocardial RevascularizationPercutaneous Coronary InterventionPostoperative HemorrhagePrognosisProspective StudiesSurvival RateTriageConceptsST-segment elevation myocardial infarctionPercutaneous coronary interventionTarget lesion calciumAcute coronary syndromeSegment elevation acute coronary syndromesElevation acute coronary syndromeElevation myocardial infarctionLesion calciumMajor bleedingCoronary syndromeCoronary calciumMyocardial infarctionCoronary interventionIndependent predictorsIndependent angiographic core laboratoryUrgent Intervention Triage StrategyAdverse ischemic eventsMajor bleeding eventsAcute myocardial infarctionHigh-risk populationAngiographic core laboratoryBleeding eventsHarmonizing OutcomesSevere calciumIschemic eventsThe prognostic importance of left ventricular function in patients with ST-segment elevation myocardial infarction: the HORIZONS-AMI trial
Ng VG, Lansky AJ, Meller S, Witzenbichler B, Guagliumi G, Peruga JZ, Brodie B, Shah R, Mehran R, Stone GW. The prognostic importance of left ventricular function in patients with ST-segment elevation myocardial infarction: the HORIZONS-AMI trial. European Heart Journal Acute Cardiovascular Care 2013, 3: 67-77. PMID: 24562805, PMCID: PMC3932775, DOI: 10.1177/2048872613507149.Peer-Reviewed Original ResearchMeSH KeywordsAgedAntithrombinsCoronary AngiographyDrug-Eluting StentsElectrocardiographyFemaleFollow-Up StudiesGated Blood-Pool ImagingHirudinsHumansMaleMiddle AgedMyocardial InfarctionPeptide FragmentsPercutaneous Coronary InterventionPrognosisProspective StudiesRecombinant ProteinsTreatment OutcomeVentricular Function, LeftConceptsST-segment elevation myocardial infarctionLeft ventricular ejection fractionPaclitaxel-eluting stentsHORIZONS-AMI trialElevation myocardial infarctionLV dysfunctionLV functionMyocardial infarctionIschaemia-driven target lesion revascularizationMajor adverse cardiovascular eventsNet adverse clinical eventsPrimary percutaneous coronary interventionBaseline LV dysfunctionIndex revascularization procedureAdverse cardiovascular eventsOutcomes of patientsTarget lesion revascularizationHigh-risk patientsSubstantial clinical benefitAdverse clinical eventsNormal LV functionPercutaneous coronary interventionVentricular ejection fractionLeft ventricular functionBare metal stentsPrognostic Utility of the SYNTAX Score in Patients With Single Versus Multivessel Disease Undergoing Percutaneous Coronary Intervention (from the Acute Catheterization and Urgent Intervention Triage StrategY [ACUITY] Trial)
Caixeta A, Généreux P, Palmerini T, Lansky AJ, Mehran R, Dangas GD, Xu K, Brener SJ, Stone GW. Prognostic Utility of the SYNTAX Score in Patients With Single Versus Multivessel Disease Undergoing Percutaneous Coronary Intervention (from the Acute Catheterization and Urgent Intervention Triage StrategY [ACUITY] Trial). The American Journal Of Cardiology 2013, 113: 203-210. PMID: 24176063, DOI: 10.1016/j.amjcard.2013.08.035.Peer-Reviewed Original ResearchConceptsMultivessel coronary artery diseaseMajor adverse cardiac eventsSingle-vessel diseasePercutaneous coronary interventionSurgery scoreCoronary interventionClinical outcomesMyocardial infarctionRate of MACETaxus drug-eluting stentsCardiac Surgery (SYNTAX) scoreOverall study cohortAdverse cardiac eventsCoronary artery diseaseDrug-eluting stentsACUITY trialMultivessel diseaseSS tertilesAngiographic predictorsSYNTAX scoreCardiac eventsThird tertileArtery diseaseCardiac deathIndependent predictorsComplementary prognostic utility of myocardial blush grade and ST-segment resolution after primary percutaneous coronary intervention: Analysis from the HORIZONS-AMI trial
Brener SJ, Dizon JM, Mehran R, Guerchicoff A, Lansky AJ, Farkouh M, Brodie B, Guagliumi G, Witzenbichler B, Fahy M, Parise H, Stone GW. Complementary prognostic utility of myocardial blush grade and ST-segment resolution after primary percutaneous coronary intervention: Analysis from the HORIZONS-AMI trial. American Heart Journal 2013, 166: 676-683. PMID: 24093847, DOI: 10.1016/j.ahj.2013.07.025.Peer-Reviewed Original ResearchConceptsPrimary percutaneous coronary interventionST-segment resolutionMyocardial blush gradePrimary PCIPercutaneous coronary interventionBlush gradeHORIZONS-AMIMBG 2/3Coronary interventionPrognostic utilityMajor adverse cardiac eventsMyocardial blush grade 2/3ST-elevation myocardial infarctionHORIZONS-AMI trialAdverse cardiac eventsPredictors of deathIndependent prognostic significanceComplementary prognostic informationLong-term outcomesLong-term survivalCardiac eventsReperfusion successIndependent predictorsGrade 2/3Multivariable analysisAlmanac 2013: acute coronary syndromes
Meier P, Lansky AJ, Baumbach A. Almanac 2013: acute coronary syndromes. Heart 2013, 99: 1488. PMID: 23945172, DOI: 10.1136/heartjnl-2013-304649.Peer-Reviewed Original ResearchConceptsST-elevation myocardial infarctionAcute coronary syndromeCoronary syndromeCardiac arrestUnstable coronary artery plaqueRecent therapeutic progressElevation myocardial infarctionNovel antiplatelet agentsCoronary artery plaquesSudden cardiac arrestCommon underlying causeACS mortalityElevation infarctionUnstable anginaAntiplatelet agentsArtery plaquesMyocardial infarctionTherapeutic progressUnderlying causeInfarctionSyndromeArrestAnginaPrasugrelCangrelorRelationship Between ST-Segment Recovery and Clinical Outcomes After Primary Percutaneous Coronary Intervention
Farkouh ME, Reiffel J, Dressler O, Nikolsky E, Parise H, Cristea E, Baran DA, Dizon J, Merab JP, Lansky AJ, Mehran R, Stone GW. Relationship Between ST-Segment Recovery and Clinical Outcomes After Primary Percutaneous Coronary Intervention. Circulation Cardiovascular Interventions 2013, 6: 216-223. PMID: 23652600, DOI: 10.1161/circinterventions.112.000142.Peer-Reviewed Original ResearchMeSH KeywordsAgedChi-Square DistributionCoronary AngiographyElectrocardiographyFemaleFibrinolytic AgentsHumansKaplan-Meier EstimateMaleMiddle AgedMultivariate AnalysisMyocardial InfarctionPercutaneous Coronary InterventionPlatelet Aggregation InhibitorsProportional Hazards ModelsRecovery of FunctionRisk FactorsStentsTime FactorsTreatment OutcomeConceptsPrimary percutaneous coronary interventionST-segment elevation myocardial infarctionPrimary PCIMajor adverse cardiovascular eventsST-segment resolutionAdverse cardiovascular eventsIschemia-driven target vessel revascularizationComplete ST-segment resolutionTarget vessel revascularizationPercutaneous coronary interventionMyocardial infarctionCardiovascular eventsVessel revascularizationCoronary interventionIndependent predictorsDegree of STRBaseline ST-segment elevationAcute Myocardial Infarction trialLong-term prognostic valueLong-term cardiovascular mortalityLeft ventricular ejection fractionLong-term predictive valuePost-PCI electrocardiogramsMyocardial infarction (TIMI) flowMyocardial Infarction trialSelection and timing for invasive therapy in non-ST-segment-elevation acute coronary syndrome
Meier P, Fröhlich GM, Meller S, De Palma R, Lansky AJ. Selection and timing for invasive therapy in non-ST-segment-elevation acute coronary syndrome. Expert Review Of Cardiovascular Therapy 2013, 11: 437-445. PMID: 23570357, DOI: 10.1586/erc.13.23.Peer-Reviewed Original ResearchConceptsSegment elevation acute coronary syndromesST-segment elevation myocardial infarctionAcute coronary syndromeCoronary syndromeMyocardial infarctionLong-term mortalityBest treatment strategyOptimal time pointNSTEACS patientsTerm mortalityCoronary angiographyOptimal therapyPoor prognosisTreatment strategiesInvasive therapyHigh mortalityOlder agePatientsTime pointsMortalityNSTEACSInfarctionSyndromeTherapyAngiographyImpact of infarct-related artery patency before primary PCI on outcome in patients with ST-segment elevation myocardial infarction: the HORIZONS-AMI trial.
Rakowski T, Dudek D, Dziewierz A, Yu J, Witzenbichler B, Guagliumi G, Kornowski R, Hartmann F, Lansky AJ, Brener SJ, Mehran R, Stone GW. Impact of infarct-related artery patency before primary PCI on outcome in patients with ST-segment elevation myocardial infarction: the HORIZONS-AMI trial. EuroIntervention 2013, 8: 1307-14. PMID: 23538158, DOI: 10.4244/eijv8i11a199.Peer-Reviewed Original ResearchMeSH KeywordsAgedChi-Square DistributionCoronary AngiographyCoronary CirculationCoronary StenosisCoronary VesselsElectrocardiographyFemaleHumansKaplan-Meier EstimateMaleMiddle AgedMultivariate AnalysisMyocardial InfarctionPercutaneous Coronary InterventionPredictive Value of TestsProportional Hazards ModelsProspective StudiesRisk AssessmentRisk FactorsThrombosisTime FactorsTreatment OutcomeVascular PatencyConceptsEarly IRA patencyPrimary percutaneous coronary interventionPercutaneous coronary interventionHORIZONS-AMI trialOne-year mortalityIRA patencyIndependent predictorsST-segment elevation myocardial infarctionMyocardial blush grade 2Infarct-related artery patencyBaseline coronary angiographyBetter TIMI flowMyocardial Infarction 2Probable stent thrombosisTIMI 3 flowOne-year outcomesOutcomes of patientsElevation myocardial infarctionGood angiographic resultBaseline angiographyTIMI 0TIMI flowArtery patencyCoronary interventionCoronary angiography
2012
Long-Term Prognosis of Patients Presenting With ST-Segment Elevation Myocardial Infarction With No Significant Coronary Artery Disease (from The HORIZONS-AMI Trial)
Larsen AI, Nilsen DW, Yu J, Mehran R, Nikolsky E, Lansky AJ, Caixeta A, Parise H, Fahy M, Cristea E, Witzenbichler B, Guagliumi G, Peruga JZ, Brodie BR, Dudek D, Stone GW. Long-Term Prognosis of Patients Presenting With ST-Segment Elevation Myocardial Infarction With No Significant Coronary Artery Disease (from The HORIZONS-AMI Trial). The American Journal Of Cardiology 2012, 111: 643-648. PMID: 23261001, DOI: 10.1016/j.amjcard.2012.11.011.Peer-Reviewed Original ResearchConceptsST-segment elevation myocardial infarctionSignificant coronary artery diseaseCoronary artery diseaseElevation myocardial infarctionArtery diseaseMyocardial infarctionGreater left ventricular ejection fractionMajor adverse cardiovascular eventsNet adverse clinical eventsAcute Myocardial Infarction trialObstructive coronary artery diseaseLeft ventricular ejection fractionLower body mass indexBaseline coronary angiogramAdverse cardiovascular eventsCoronary artery bypassMyocardial Infarction trialNormal coronary arteriesOutcomes of patientsAdverse clinical eventsPrognosis of patientsVentricular ejection fractionBody mass indexQuantitative coronary angiographyRate of deathOperator Versus Core Laboratory Assessment of Angiographic Reperfusion Markers in Patients Undergoing Primary Percutaneous Coronary Intervention for ST-Segment–Elevation Myocardial Infarction
Brener SJ, Cristea E, Lansky AJ, Fahy M, Mehran R, Stone GW. Operator Versus Core Laboratory Assessment of Angiographic Reperfusion Markers in Patients Undergoing Primary Percutaneous Coronary Intervention for ST-Segment–Elevation Myocardial Infarction. Circulation Cardiovascular Interventions 2012, 5: 563-569. PMID: 22828707, DOI: 10.1161/circinterventions.112.969022.Peer-Reviewed Original ResearchMeSH KeywordsAgedAnticoagulantsAntithrombinsCoronary AngiographyCoronary CirculationDrug-Eluting StentsElectrocardiographyFemaleHeparinHirudinsHumansMaleMiddle AgedMultivariate AnalysisMyocardial InfarctionObserver VariationPaclitaxelPeptide FragmentsPercutaneous Coronary InterventionPredictive Value of TestsPrognosisRecombinant ProteinsTubulin ModulatorsConceptsPrimary percutaneous coronary interventionMyocardial blush gradeST-segment elevation myocardial infarctionPercutaneous coronary interventionTIMI flowMyocardial infarctionCoronary interventionMBG 2Post-PCI myocardial blush gradePost-PCI TIMI 3 flowPrimary PCIFinal myocardial blush gradeFinal TIMI flow 0Pre-PCI TIMI flowCore laboratory assessmentFinal TIMI flowRelative prognostic utilityTIMI flow 0Myocardial infarction (TIMI) flowTIMI 3 flowElevation myocardial infarctionImportant prognostic indicatorHarmonizing OutcomesMBG 0Reperfusion marker
2011
Predictors and Implications of Stent Thrombosis in Non–ST-Segment Elevation Acute Coronary Syndromes
Palmerini T, Dangas G, Mehran R, Caixeta A, Généreux P, Fahy MP, Xu K, Cristea E, Lansky AJ, Stone GW. Predictors and Implications of Stent Thrombosis in Non–ST-Segment Elevation Acute Coronary Syndromes. Circulation Cardiovascular Interventions 2011, 4: 577-584. PMID: 22028471, DOI: 10.1161/circinterventions.111.963884.Peer-Reviewed Original ResearchMeSH KeywordsAcute Coronary SyndromeAgedAngioplasty, Balloon, CoronaryComorbidityCoronary ThrombosisCoronary VesselsDiabetes Mellitus, Type 1Drug-Eluting StentsElectrocardiographyFemaleFibrinolytic AgentsFollow-Up StudiesHumansMaleMetalsMiddle AgedPredictive Value of TestsPrevalenceProspective StudiesRisk FactorsStentsConceptsSegment elevation acute coronary syndromesElevation acute coronary syndromeProbable stent thrombosisAcute coronary syndromeStent thrombosisNSTE-ACSCardiac mortalityCoronary syndromeIndependent predictorsStent implantationDiseased vesselsUrgent Intervention Triage Strategy (ACUITY) trialDynamic ST segment changesIncidence of STInsulin-treated diabetes mellitusElective stent implantationEarly stent thrombosisPercutaneous coronary interventionST-segment changesBare metal stentsDrug-eluting stentsLate stent thrombosisST-segment deviationAcute CatheterizationAntithrombotic regimensRelationship between angiographic dynamic and densitometric assessment of myocardial reperfusion and survival in patients with acute myocardial infarction treated with primary percutaneous coronary intervention: The Harmonizing Outcomes with Revascularization and Stents in AMI (HORIZONS-AMI) trial
Brener SJ, Cristea E, Mehran R, Dressler O, Lansky AJ, Stone GW. Relationship between angiographic dynamic and densitometric assessment of myocardial reperfusion and survival in patients with acute myocardial infarction treated with primary percutaneous coronary intervention: The Harmonizing Outcomes with Revascularization and Stents in AMI (HORIZONS-AMI) trial. American Heart Journal 2011, 162: 1044-1051. PMID: 22137078, DOI: 10.1016/j.ahj.2011.08.022.Peer-Reviewed Original ResearchConceptsST-segment elevation myocardial infarctionPrimary percutaneous coronary interventionPercutaneous coronary interventionCoronary interventionIndependent predictorsMyocardial infarctionMyocardial perfusionHORIZONS-AMI studyEarly clinical outcomesLong-term mortalityElevation myocardial infarctionAcute myocardial infarctionHarmonizing OutcomesLate mortalityAMI trialEpicardial flowMyocardial reperfusionClinical outcomesGrade 2/3Multivariable analysisLate survivalPatientsMortalityTime pointsDensitometric assessmentPrognostic Impact of Staged Versus “One-Time” Multivessel Percutaneous Intervention in Acute Myocardial Infarction Analysis From the HORIZONS-AMI (Harmonizing Outcomes With Revascularization and Stents in Acute Myocardial Infarction) Trial
Kornowski R, Mehran R, Dangas G, Nikolsky E, Assali A, Claessen BE, Gersh BJ, Wong SC, Witzenbichler B, Guagliumi G, Dudek D, Fahy M, Lansky AJ, Stone GW, Investigators H. Prognostic Impact of Staged Versus “One-Time” Multivessel Percutaneous Intervention in Acute Myocardial Infarction Analysis From the HORIZONS-AMI (Harmonizing Outcomes With Revascularization and Stents in Acute Myocardial Infarction) Trial. Journal Of The American College Of Cardiology 2011, 58: 704-711. PMID: 21816305, DOI: 10.1016/j.jacc.2011.02.071.Peer-Reviewed Original ResearchConceptsPrimary percutaneous coronary interventionST-segment elevation myocardial infarctionMultivessel primary percutaneous coronary interventionMajor adverse cardiovascular eventsHORIZONS-AMI trialAdverse cardiovascular eventsMultivessel diseaseNonculprit lesionsCardiovascular eventsStent thrombosisPCI strategyPrimary PCIAcute Myocardial Infarction AnalysisProbable stent thrombosisTarget vessel revascularizationElevation myocardial infarctionPercutaneous coronary interventionSubgroup of patientsPrimary PCI proceduresMultivessel percutaneous interventionNonculprit vesselsCardiac mortalityCause mortalityCulprit lesionSTEMI patientsPredictors and Implications of Coronary Infarct Artery Patency at Initial Angiography in Patients With Acute Myocardial Infarction (from the CADILLAC and HORIZONS-AMI Trials)
Brener SJ, Mehran R, Brodie BR, Guagliumi G, Witzenbichler B, Cristea E, Xu K, Lansky AJ, Stone GW. Predictors and Implications of Coronary Infarct Artery Patency at Initial Angiography in Patients With Acute Myocardial Infarction (from the CADILLAC and HORIZONS-AMI Trials). The American Journal Of Cardiology 2011, 108: 918-923. PMID: 21764028, DOI: 10.1016/j.amjcard.2011.05.022.Peer-Reviewed Original ResearchMeSH KeywordsAbciximabAgedAngioplasty, Balloon, CoronaryAntibodies, MonoclonalCoronary AngiographyCoronary CirculationCoronary VesselsDrug-Eluting StentsElectrocardiographyFemaleFollow-Up StudiesHumansImmunoglobulin Fab FragmentsMaleMiddle AgedMyocardial InfarctionPlatelet Aggregation InhibitorsPredictive Value of TestsRegional Blood FlowVascular PatencyConceptsTIMI grade 3 flowGrade 3 flowFinal TIMI grade 3 flowST-segment elevation myocardial infarctionElevation myocardial infarctionIndependent predictorsMyocardial infarctionPre-percutaneous coronary intervention (PCI) thrombolysisMyocardial Infarction (TIMI) grade 3 flowAcute Myocardial Infarction trialExtensive coronary diseaseLate Angioplasty ComplicationsMyocardial Infarction trialInfarct artery patencyAcute myocardial infarctionSignificant independent predictorsHigh-risk characteristicsAngioplasty complicationsBaseline TIMIControlled AbciximabHarmonizing OutcomesInitial angiographyCause mortalityPrimary PCIArtery patency