2006
Safety of beta radiation exposure to the non-target segment: an intravascular ultrasound dosimetric analysis.
Kaneda H, Honda Y, Morino Y, Fox T, Crocker I, Lansky AJ, Yock PG, Bonan R, Fitzgerald PJ. Safety of beta radiation exposure to the non-target segment: an intravascular ultrasound dosimetric analysis. Journal Of Invasive Cardiology 2006, 18: 309-12. PMID: 16816435.Peer-Reviewed Original ResearchMeSH KeywordsAgedBeta ParticlesCoronary AngiographyCoronary RestenosisCoronary VesselsDose-Response Relationship, RadiationFemaleHumansMaleMiddle AgedRadiometryTreatment OutcomeUltrasonography, InterventionalConceptsDosimetric analysisDistal segmentsRadiation exposureDistal reference sitesStent restenosis casesSignificant serial changesGreater radiation exposurePositive vessel remodelingRestenosis casesBeta radiation exposureLumen lossPositive remodelingCoronary arteryPlaque volumeGeographic missPlaque areaDistal vasculatureSerial changesPlaque massPlaque increasePrescribed doseVessel changesMild increaseMinimum doseVessel remodelingA multicenter, randomized, dose-finding study of gamma intracoronary radiation therapy to inhibit recurrent restenosis after stenting.
Price MJ, Moses JW, Leon MB, Mehran R, Negoita M, Lansky A, Collins M, Giap H, Lin R, Jani S, Steuterman S, Balter S, Dalton J, Lipsztein R, Tripuraneni P, Teirstein PS. A multicenter, randomized, dose-finding study of gamma intracoronary radiation therapy to inhibit recurrent restenosis after stenting. Journal Of Invasive Cardiology 2006, 18: 169-73. PMID: 16732060.Peer-Reviewed Original ResearchMeSH KeywordsAgedCoronary RestenosisCoronary VesselsDose-Response Relationship, RadiationDouble-Blind MethodFemaleFollow-Up StudiesGamma RaysHumansMaleMetalsMiddle AgedStentsTreatment OutcomeConceptsIntracoronary radiation therapyStent restenosisRadiation therapyLesion late lossTarget lesion revascularizationHigh-dose groupDose-finding studySignificant clinical problemBare metal stentsRadiation dose prescriptionHigh radiation doseBinary restenosisLesion revascularizationRecurrent restenosisVessel revascularizationAdverse eventsCoronary interventionRecurrent stenosisComposite endpointRandomized studyDose groupClinical eventsMyocardial infarctionRadiation failureGy group
2002
Balloon‐based radiation therapy for treatment of in‐stent restenosis in human coronary arteries: Results from the BRITE I study
Waksman R, Buchbinder M, Reisman M, Lansky AJ, Trauthen B, Whiting J, Li A. Balloon‐based radiation therapy for treatment of in‐stent restenosis in human coronary arteries: Results from the BRITE I study. Catheterization And Cardiovascular Interventions 2002, 57: 286-294. PMID: 12410499, DOI: 10.1002/ccd.10359.Peer-Reviewed Original ResearchMeSH KeywordsAgedArteriesBlood Vessel ProsthesisCatheterizationCoronary AngiographyCoronary RestenosisDose-Response Relationship, RadiationFemaleFollow-Up StudiesHumansIncidenceMaleMiddle AgedPilot ProjectsProspective StudiesRadiotherapy, Computer-AssistedReoperationRisk FactorsStentsTime FactorsTreatment OutcomeConceptsStent restenosisRadiation therapyMajor adverse cardiac eventsAdverse cardiac eventsIntracoronary radiation therapyStudy eligibility criteriaStent restenosis resultsInstances of deathHuman coronary arteriesBinary restenosisRepeat PTCAPrimary endpointCardiac eventsClinical restenosisEmergency surgeryLate complicationsAngioplasty siteRestenosis rateRecurrence rateTotal occlusionConventional therapyCoronary arteryEligibility criteriaLate thrombosisTarget vesselDelivered Dose and Vascular Response After β-Radiation for In-Stent Restenosis
Morino Y, Kaneda H, Fox T, Takagi A, Hassan AH, Bonan R, Crocker I, Lansky AJ, Laskey WK, Suntharalingam M, Bonneau HN, Yock PG, Honda Y, Fitzgerald PJ. Delivered Dose and Vascular Response After β-Radiation for In-Stent Restenosis. Circulation 2002, 106: 2334-2339. PMID: 12403663, DOI: 10.1161/01.cir.0000036367.17043.03.Peer-Reviewed Original ResearchMeSH KeywordsBeta ParticlesBlood Vessel Prosthesis ImplantationBrachytherapyCohort StudiesCoronary AngiographyCoronary Artery DiseaseCoronary RestenosisCoronary VesselsDose-Response Relationship, RadiationFemaleHumansLinear ModelsMaleMiddle AgedRadiation DosageRadiometryRetrospective StudiesStentsTreatment OutcomeUltrasonography, InterventionalVascular PatencyConceptsIntimal hyperplasia volumeDose intensityVolumetric intravascular ultrasound analysisDose-dependent complicationsRadiation therapy trialsSerial Volumetric Intravascular Ultrasound AnalysisStent restenosis casesStent restenosis lesionsIn-Stent RestenosisIntravascular ultrasound analysisPrescribed radiation doseSource trainRestenosis casesRestenosis lesionsVascular changesVascular responsesTherapy trialsDose prescriptionLong subsegmentsDevice injuryUltrasound analysisStent segmentDoseDose rangeIVUS catheterDevice selection in the treatment of in-stent restenosis with and without radiation (from the Gamma Radiation Trials)
Ajani AE, Waksman R, Zimarino M, Kim H, Pichard AD, Satler LF, Kent KM, White RL, Pinnow E, Mehran R, Lansky A, Lindsay J. Device selection in the treatment of in-stent restenosis with and without radiation (from the Gamma Radiation Trials). The American Journal Of Cardiology 2002, 89: 137-144. PMID: 11792331, DOI: 10.1016/s0002-9149(01)02189-0.Peer-Reviewed Original ResearchMeSH KeywordsAgedAnalysis of VarianceAngioplastyAngioplasty, Balloon, CoronaryChi-Square DistributionCoronary DiseaseDose-Response Relationship, RadiationFemaleHumansIridium RadioisotopesLogistic ModelsMaleMiddle AgedProspective StudiesRisk FactorsSecondary PreventionStentsTreatment OutcomeVascular PatencyConceptsExcimer laser coronary angioplastyMajor adverse coronary eventsAdditional stent implantationTreatment of ISRRecurrence rateCoronary angioplastyRotational atherectomyStent implantationStent restenosisBalloon percutaneous transluminal coronary angioplastyPercutaneous transluminal coronary angioplastyIntracoronary gamma radiationLate clinical outcomesAdverse coronary eventsOverall recurrence rateTransluminal coronary angioplastyLaser coronary angioplastyHigh recurrence rateUse of stentingDevice selectionAngiographic characteristicsMACE ratePlacebo groupPlacebo therapyCoronary events
2001
Localized Intracoronary Gamma-Radiation Therapy to Inhibit the Recurrence of Restenosis after Stenting
Leon M, Teirstein P, Moses J, Tripuraneni P, Lansky A, Jani S, Wong S, Fish D, Ellis S, Holmes D, Kerieakes D, Kuntz R. Localized Intracoronary Gamma-Radiation Therapy to Inhibit the Recurrence of Restenosis after Stenting. New England Journal Of Medicine 2001, 344: 250-256. PMID: 11172151, DOI: 10.1056/nejm200101253440402.Peer-Reviewed Original ResearchMeSH KeywordsAngioplasty, Balloon, CoronaryBrachytherapyCombined Modality TherapyCoronary DiseaseCoronary ThrombosisDose-Response Relationship, RadiationDouble-Blind MethodFemaleGamma RaysHumansIridium RadioisotopesMaleMiddle AgedMultivariate AnalysisMyocardial InfarctionPlatelet Aggregation InhibitorsRadiotherapy DosageSecondary PreventionStentsConceptsIridium-192 groupMyocardial infarctionLate thrombosisStent restenosisIridium-192Intracoronary irradiationTarget lesionsIntracoronary gamma radiation therapyMajor adverse cardiac eventsFrequency of restenosisOral antiplatelet therapyAdverse cardiac eventsComposite of deathPrimary end pointLate myocardial infarctionIntracoronary radiation therapyIncidence of deathRecurrence of restenosisGamma radiation therapyEligible patientsAngiographic restenosisAntiplatelet therapyPlacebo groupCardiac eventsCoronary angioplasty