2012
The Future REvascularization Evaluation in patients with Diabetes mellitus: Optimal management of Multivessel disease (FREEDOM) trial: Clinical and angiographic profile at study entry
Bansilal S, Farkouh ME, Hueb W, Ogdie M, Dangas G, Lansky AJ, Cohen DJ, Magnuson EA, Ramanathan K, Tanguay JF, Muratov V, Sleeper LA, Domanski M, Bertrand ME, Fuster V. The Future REvascularization Evaluation in patients with Diabetes mellitus: Optimal management of Multivessel disease (FREEDOM) trial: Clinical and angiographic profile at study entry. American Heart Journal 2012, 164: 591-599. PMID: 23067919, PMCID: PMC4536808, DOI: 10.1016/j.ahj.2012.06.012.Peer-Reviewed Original ResearchConceptsMultivessel coronary artery diseasePercutaneous coronary interventionDiabetic patientsFREEDOM trialBaseline characteristicsContemporary coronary artery bypassFuture Revascularization EvaluationMean hemoglobin A1cMean SYNTAX scoreMultivessel Disease (FREEDOM) trialOptimal medical therapyOptimal revascularization strategyCoronary artery bypassRisk factor controlMedian diabetes durationPrior myocardial infarctionSystolic blood pressureCoronary artery diseaseDrug-eluting stentsLow-density lipoproteinAngiographic profileVascular medicationsArtery bypassDiabetes durationSYNTAX scoreAn intravascular ultrasound appraisal of atherosclerotic plaque distribution in diseased coronary arteries
Golinvaux N, Maehara A, Mintz GS, Lansky AJ, McPherson J, Farhat N, Marso S, de Bruyne B, Serruys PW, Templin B, Cheong WF, Aaskar R, Fahy M, Mehran R, Leon M, Stone GW. An intravascular ultrasound appraisal of atherosclerotic plaque distribution in diseased coronary arteries. American Heart Journal 2012, 163: 624-631. PMID: 22520529, DOI: 10.1016/j.ahj.2011.07.031.Peer-Reviewed Original ResearchConceptsRight coronary arteryCoronary arteryPlaque burdenDistal segmentsDistal LADDistal right coronary arteryAtherosclerotic plaque distributionAnterior descending (LAD) arteryDistal coronary arteriesProximal coronary arteriesDiseased coronary arteriesExternal elastic membraneProximal cross sectionsArtery plaquesIntravascular ultrasound dataPlaque distributionProximal vesselsMid segmentsIntravascular ultrasoundMedian percentageArteryProximal segmentSignificant diseaseLADDisease
2011
Paclitaxel-Eluting Stents Compared With Bare Metal Stents in Diabetic Patients With Acute Myocardial Infarction
Witzenbichler B, Wöhrle J, Guagliumi G, Peruga JZ, Brodie BR, Dudek D, Kornowski R, Hartmann F, Hood KL, Parise H, Lansky AJ, Nikolsky E, Mehran R, Stone GW. Paclitaxel-Eluting Stents Compared With Bare Metal Stents in Diabetic Patients With Acute Myocardial Infarction. Circulation Cardiovascular Interventions 2011, 4: 130-138. PMID: 21364152, DOI: 10.1161/circinterventions.110.960245.Peer-Reviewed Original ResearchConceptsST-segment elevation myocardial infarctionPaclitaxel-eluting stentsTarget lesion revascularizationBare metal stentsHORIZONS-AMI trialDiabetic patientsDiabetes mellitusStent thrombosisMyocardial infarctionPercutaneous interventionIschemia-driven target lesion revascularizationMetal stentsAcute Myocardial Infarction trialHigh-risk diabetic patientsMyocardial Infarction trialPrimary percutaneous interventionInsulin-treated diabetesAcute myocardial infarctionAngiographic late lossComparable safety outcomesBinary restenosisHarmonizing OutcomesLesion revascularizationNondiabetic patientsAngiographic restenosis
2004
Impact of chronic kidney disease on prognosis of patients with diabetes mellitus treated with percutaneous coronary intervention
Nikolsky E, Mehran R, Turcot D, Aymong ED, Mintz GS, Lasic Z, Lansky AJ, Tsounias E, Moses JW, Stone GW, Leon MB, Dangas GD. Impact of chronic kidney disease on prognosis of patients with diabetes mellitus treated with percutaneous coronary intervention. The American Journal Of Cardiology 2004, 94: 300-305. PMID: 15276092, DOI: 10.1016/j.amjcard.2004.04.023.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAgedAngioplasty, Balloon, CoronaryCause of DeathChi-Square DistributionCohort StudiesCoronary DiseaseDiabetic AngiopathiesFemaleHumansKidney Failure, ChronicMaleMiddle AgedProbabilityPrognosisRenal DialysisRisk AssessmentSeverity of Illness IndexSex FactorsStatistics, NonparametricStentsSurvival AnalysisTreatment OutcomeConceptsChronic kidney diseasePercutaneous coronary interventionContrast-induced nephropathyPrognosis of patientsCoronary interventionRenal functionDiabetes mellitusKidney diseaseMortality rateImpact of CKDRole of CKDDe novo dialysisOutcomes of patientsHospital complicationsGastrointestinal bleedingNeurologic eventsFrequent complicationDiabetic patientsIndependent predictorsInsulin treatmentPatientsContrast mediumNephropathyDialysisMellitus
2003
Vascular brachytherapy using a beta emitter source in diabetic patients with in-stent restenosis: Angiographic and clinical outcomes
Suntharalingam M, Laskey WK, Tantibhedhyangkul W, Lansky A, Teirstein P, Bass T, Silber S, Rutherford B, Wilmer C, Popma JJ, Kuntz R, Bonan R. Vascular brachytherapy using a beta emitter source in diabetic patients with in-stent restenosis: Angiographic and clinical outcomes. International Journal Of Radiation Oncology • Biology • Physics 2003, 57: 536-542. PMID: 12957267, DOI: 10.1016/s0360-3016(03)00537-6.Peer-Reviewed Original ResearchConceptsVessel revascularization ratePercutaneous coronary interventionDiabetic patientsNondiabetic patientsVascular brachytherapyNondiabetic counterpartsStent restenosisRevascularization ratesCoronary interventionLess target lesion revascularizationConventional percutaneous coronary interventionBinary angiographic restenosisAngiographic restenosis rateTarget lesion revascularizationReference vessel diameterComplex coronary lesionsMinimal lumen diameterStudy of patientsPercent diameter stenosisVessel diameterTreatment effectsBeta-Cath SystemBreslow-Day testLesion revascularizationAngiographic restenosis
2000
Current perspectives on interventional treatment strategies in diabetic patients with coronary artery disease
Kornowski R, Lansky A. Current perspectives on interventional treatment strategies in diabetic patients with coronary artery disease. Catheterization And Cardiovascular Interventions 2000, 50: 245-254. PMID: 10842400, DOI: 10.1002/(sici)1522-726x(200006)50:2<245::aid-ccd22>3.0.co;2-p.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseCoronary interventionBypass surgeryArtery diseaseDiabetes mellitusDiabetic patientsClinical outcomesCoronary artery bypass surgeryDiffuse coronary artery diseaseCatheter-based coronary interventionsArtery bypass surgeryCoronary bypass surgeryInterventional treatment strategiesPercutaneous coronary interventionUse of antiplateletAtherosclerosis lesion progressionTarget vessel sizeAdjunctive pharmacologyMore restenosisMultivessel diseaseAtherosclerosis burdenCoronary atherosclerosisCoronary proceduresCoronary sitesAdjunctive pharmacotherapy
1998
Paradoxic Decreases in Atherosclerotic Plaque Mass in Insulin-Treated Diabetic Patients
Kornowski R, Mintz G, Lansky A, Hong M, Kent K, Pichard A, Satler L, Popma J, Bucher T, Leon M. Paradoxic Decreases in Atherosclerotic Plaque Mass in Insulin-Treated Diabetic Patients. The American Journal Of Cardiology 1998, 81: 1298-1304. PMID: 9631966, DOI: 10.1016/s0002-9149(98)00157-x.Peer-Reviewed Original ResearchConceptsArterial areaPlaque accumulationLumen compromiseDe novo native coronary stenosisInsulin-treated patientsInsulin-treated diabeticsNative coronary stenosisMultivariate linear regression analysisAtherosclerotic lesion formationBody surface areaParadoxic decreaseInsulin useDiabetes mellitusDiabetic patientsIndependent predictorsRemodeling indexAnginal syndromePlaque burdenCoronary stenosisArterial shrinkageInsulin treatmentPlaque massIntravascular ultrasoundLinear regression analysisReference segments