2017
Predictors of Left Ventricular Ejection Fraction Improvement After Primary Stenting in ST-Segment Elevation Myocardial Infarction (from the Harmonizing Outcomes With Revascularization and Stents in Acute Myocardial Infarction Trial)
Serrao GW, Lansky AJ, Mehran R, Stone GW. Predictors of Left Ventricular Ejection Fraction Improvement After Primary Stenting in ST-Segment Elevation Myocardial Infarction (from the Harmonizing Outcomes With Revascularization and Stents in Acute Myocardial Infarction Trial). The American Journal Of Cardiology 2017, 121: 678-683. PMID: 29394998, DOI: 10.1016/j.amjcard.2017.12.004.Peer-Reviewed Original ResearchMeSH KeywordsAgedAntithrombinsBiomarkersCoronary AngiographyFemaleHeparinHirudinsHumansMaleMiddle AgedPeptide FragmentsPlatelet Glycoprotein GPIIb-IIIa ComplexPredictive Value of TestsRecombinant ProteinsRisk AssessmentRisk FactorsST Elevation Myocardial InfarctionStentsStroke VolumeTreatment OutcomeVentricular Dysfunction, LeftConceptsST-segment elevation myocardial infarctionPrimary percutaneous coronary interventionLeft ventricular ejection fractionPrimary PCIAcute Myocardial Infarction trialMyocardial Infarction trialElevation myocardial infarctionHarmonizing OutcomesLVEF improvementMyocardial infarctionLower baseline left ventricular ejection fractionLeft ventricular ejection fraction improvementBaseline left ventricular ejection fractionGlycoprotein IIb/IIIa inhibitorsVentricular ejection fraction improvementMyocardial Infarction 3 flowIIb/IIIa inhibitorsEjection fraction improvementHalf of patientsPercutaneous coronary interventionVentricular ejection fractionPredictors of improvementPrespecified substudyPrimary stentingAngiographic predictors
2014
Relation of C-Reactive Protein Levels to Instability of Untreated Vulnerable Coronary Plaques (from the PROSPECT Study)
Kelly CR, Weisz G, Maehara A, Mintz GS, Mehran R, Lansky AJ, Parise H, de Bruyne B, Serruys PW, Stone GW. Relation of C-Reactive Protein Levels to Instability of Untreated Vulnerable Coronary Plaques (from the PROSPECT Study). The American Journal Of Cardiology 2014, 114: 376-383. PMID: 24931291, DOI: 10.1016/j.amjcard.2014.04.048.Peer-Reviewed Original ResearchMeSH KeywordsAgedBiomarkersC-Reactive ProteinCoronary AngiographyCoronary Artery DiseaseDisease ProgressionFemaleGlobal HealthHumansIncidenceInflammationMaleMiddle AgedPlaque, AtheroscleroticPredictive Value of TestsPrognosisProspective StudiesRisk AssessmentRisk FactorsSeverity of Illness IndexSurvival RateTime FactorsConceptsMajor adverse cardiac eventsC-reactive protein levelsNonculprit lesionsElevated CRP levelsCRP levelsVulnerable coronary plaquesIntravascular ultrasoundCoronary plaquesPost-acute coronary syndrome patientsSubsequent major adverse cardiac eventsGray-scale intravascular ultrasoundCoronary Tree (PROSPECT) studyUntreated nonculprit lesionsAdverse cardiac eventsAdverse coronary eventsAcute coronary syndromeCoronary syndrome patientsPercutaneous coronary interventionRadiofrequency intravascular ultrasoundPredictors of eventsProtein levelsMinimal luminal areaHigh rateCoronary eventsCoronary syndrome
2013
Plaque shift and distal embolism in patients with acute myocardial infarction
Wu X, Maehara A, He Y, Xu K, Oviedo C, Witzenbichler B, Lansky AJ, Dressler O, Parise H, Stone GW, Mintz GS. Plaque shift and distal embolism in patients with acute myocardial infarction. Catheterization And Cardiovascular Interventions 2013, 82: 203-209. PMID: 22936619, DOI: 10.1002/ccd.24644.Peer-Reviewed Original ResearchMeSH KeywordsAgedBiomarkersChi-Square DistributionCoronary AngiographyCoronary Artery DiseaseCoronary ThrombosisCoronary VesselsCreatine Kinase, MB FormEmbolismFemaleHumansLinear ModelsMaleMiddle AgedMyocardial InfarctionNo-Reflow PhenomenonPercutaneous Coronary InterventionPlaque, AtheroscleroticPredictive Value of TestsProsthesis DesignRandomized Controlled Trials as TopicRetrospective StudiesStentsTreatment OutcomeUltrasonography, InterventionalConceptsThrombus groupCK-MBAngiographic thrombusPlaque shiftReference segmentsAxial plaque redistributionDistal plaque embolizationDistal reference segmentsHORIZONS-AMI trialNative coronary lesionsM volumeAcute myocardial infarctionVolumetric intravascular ultrasoundBare metal stentsOverall plaque volumePeriprocedural elevationPlaque redistributionDistal embolismCoronary lesionsPlaque embolizationMyocardial infarctionStent implantationPlaque volumeInfarction lesionsIntravascular ultrasound
2012
Prognostic Significance of Elevated Baseline Troponin in Patients With Acute Coronary Syndromes and Chronic Kidney Disease Treated With Different Antithrombotic Regimens
Acharji S, Baber U, Mehran R, Fahy M, Kirtane AJ, Lansky AJ, Stone GW. Prognostic Significance of Elevated Baseline Troponin in Patients With Acute Coronary Syndromes and Chronic Kidney Disease Treated With Different Antithrombotic Regimens. Circulation Cardiovascular Interventions 2012, 5: 157-165. PMID: 22354934, DOI: 10.1161/circinterventions.111.963876.Peer-Reviewed Original ResearchMeSH KeywordsAcute Coronary SyndromeAgedAged, 80 and overBiomarkersFemaleFibrinolytic AgentsFollow-Up StudiesHeparinHirudinsHumansKidney Failure, ChronicMaleMyocardial InfarctionPeptide FragmentsPlatelet Glycoprotein GPIIb-IIIa ComplexPrognosisRecombinant ProteinsReference StandardsSurvival AnalysisTroponin TConceptsGlycoprotein IIb/IIIa inhibitorsAcute coronary syndromeBaseline troponin elevationChronic kidney diseaseMajor adverse cardiac eventsTroponin elevationMyocardial infarctionBivalirudin monotherapyMajor bleedingCKD patientsCoronary syndromeBaseline troponinKidney diseaseHigh-risk acute coronary syndromesIIb/IIIa inhibitorsLong-term clinical outcomesBaseline cardiac troponinBaseline troponin levelsDifferent antithrombotic regimensAdverse cardiac eventsACS patientsACUITY trialAntithrombotic regimensComposite deathRandomization arm
2010
Periprocedural Myocardial Infarction
Lansky AJ, Stone GW. Periprocedural Myocardial Infarction. Circulation Cardiovascular Interventions 2010, 3: 602-610. PMID: 21156928, DOI: 10.1161/circinterventions.110.959080.Peer-Reviewed Original ResearchEvaluation of the effects of everolimus‐eluting and paclitaxel‐eluting stents on target lesions with jailed side branches: 2‐year results from the SPIRIT III randomized trial
Applegate R, Hermiller J, Williams J, Gordon P, Doostzadeh J, Cao S, Su X, Sudhir K, Lansky A, Simonton C, Stone G. Evaluation of the effects of everolimus‐eluting and paclitaxel‐eluting stents on target lesions with jailed side branches: 2‐year results from the SPIRIT III randomized trial. Catheterization And Cardiovascular Interventions 2010, 76: 644-651. PMID: 20506356, DOI: 10.1002/ccd.22606.Peer-Reviewed Original ResearchMeSH KeywordsAgedAngioplasty, Balloon, CoronaryBiomarkersCardiovascular AgentsCoronary AngiographyCoronary Artery DiseaseCreatine Kinase, MB FormDrug-Eluting StentsEverolimusFemaleHumansKaplan-Meier EstimateMaleMiddle AgedMyocardial InfarctionMyocardiumNecrosisPaclitaxelProspective StudiesProsthesis DesignRisk AssessmentRisk FactorsSeverity of Illness IndexSingle-Blind MethodSirolimusTime FactorsTreatment OutcomeUnited StatesConceptsPaclitaxel-eluting stentsMajor adverse cardiac eventsTwo-year clinical outcomesTAXUS paclitaxel-eluting stentSPIRIT III trialXience V EESAdverse cardiac eventsMyocardial infarction rateUpper normal levelCreatine kinase-MBSide branchesLower ratesThinner stent strutsPeriprocedural increasePeriprocedural myonecrosisPES patientsEES groupIII trialsInfarction rateCardiac eventsSide branch compromiseCardiac deathPES groupClinical outcomesAdverse outcomes
2009
Effect of Supersaturated Oxygen Delivery on Infarct Size After Percutaneous Coronary Intervention in Acute Myocardial Infarction
Stone GW, Martin JL, de Boer MJ, Margheri M, Bramucci E, Blankenship JC, Metzger DC, Gibbons RJ, Lindsay BS, Weiner BH, Lansky AJ, Krucoff MW, Fahy M, Boscardin WJ. Effect of Supersaturated Oxygen Delivery on Infarct Size After Percutaneous Coronary Intervention in Acute Myocardial Infarction. Circulation Cardiovascular Interventions 2009, 2: 366-375. PMID: 20031745, DOI: 10.1161/circinterventions.108.840066.Peer-Reviewed Original ResearchConceptsST-segment elevation myocardial infarctionMajor adverse cardiovascular eventsElevation myocardial infarctionPercutaneous coronary interventionAdverse cardiovascular eventsAnterior ST-segment elevation myocardial infarctionInfarct sizeCoronary interventionMyocardial infarctionCardiovascular eventsLeft anteriorSymptom onsetLarge ST-segment elevation myocardial infarctionComposite major adverse cardiovascular eventsSestamibi single-photon emissionMedian infarct sizePosthoc subgroup analysisPrimary efficacy measureAcute myocardial infarctionPrimary safety measureSingle photon emissionNoninferior ratesTreat populationProtocol populationMulticenter trialImpact of Chronic Kidney Disease on Early (30-Day) and Late (1-Year) Outcomes of Patients With Acute Coronary Syndromes Treated With Alternative Antithrombotic Treatment Strategies An ACUITY (Acute Catheterization and Urgent Intervention Triage strategY) Substudy
Mehran R, Nikolsky E, Lansky AJ, Kirtane AJ, Kim YH, Feit F, Manoukian S, Moses JW, Ebrahimi R, Ohman EM, White HD, Pocock SJ, Dangas GD, Stone GW. Impact of Chronic Kidney Disease on Early (30-Day) and Late (1-Year) Outcomes of Patients With Acute Coronary Syndromes Treated With Alternative Antithrombotic Treatment Strategies An ACUITY (Acute Catheterization and Urgent Intervention Triage strategY) Substudy. JACC Cardiovascular Interventions 2009, 2: 748-757. PMID: 19695543, DOI: 10.1016/j.jcin.2009.05.018.Peer-Reviewed Original ResearchMeSH KeywordsAcute Coronary SyndromeAdultAgedAged, 80 and overAngioplasty, Balloon, CoronaryBiomarkersChronic DiseaseCoronary Artery BypassCreatinineDrug Therapy, CombinationFemaleFibrinolytic AgentsHemorrhageHeparinHirudinsHumansKidney DiseasesLogistic ModelsMaleMiddle AgedMyocardial InfarctionMyocardial IschemiaOdds RatioPeptide FragmentsPlatelet Aggregation InhibitorsPlatelet Glycoprotein GPIIb-IIIa ComplexProspective StudiesRecombinant ProteinsRisk AssessmentTime FactorsTreatment OutcomeTriageConceptsGlycoprotein IIb/IIIa inhibitorsChronic kidney diseaseAcute coronary syndromeBivalirudin monotherapyComposite ischemiaMajor bleedingCoronary syndromeClinical outcomesKidney diseaseHigh-risk acute coronary syndromesIIb/IIIa inhibitorsClinical adverse outcomesCreatinine clearance dataOutcomes of patientsNormal renal functionAdverse event ratesAntithrombotic treatment strategiesSignificant differencesACUITY trialIschemic outcomesRenal functionAdverse outcomesInvasive strategyLate outcomesTreatment strategies
2000
Long-term clinical events following creatine kinase–myocardial band isoenzyme elevation after successful coronary stenting
Saucedo J, Mehran R, Dangas G, Hong M, Lansky A, Kent K, Satler L, Pichard A, Stone G, Leon M. Long-term clinical events following creatine kinase–myocardial band isoenzyme elevation after successful coronary stenting. Journal Of The American College Of Cardiology 2000, 35: 1134-1141. PMID: 10758952, DOI: 10.1016/s0735-1097(00)00513-1.Peer-Reviewed Original ResearchMeSH KeywordsAgedAnalysis of VarianceAngioplasty, Balloon, CoronaryBiomarkersCoronary DiseaseCreatine KinaseDisease-Free SurvivalFemaleHumansIncidenceLogistic ModelsMaleMiddle AgedPredictive Value of TestsPrognosisProspective StudiesPulmonary EdemaRadiographyRecurrenceRisk FactorsSeverity of Illness IndexStentsTreatment OutcomeConceptsCK-MB elevationCreatine kinase-myocardial band isoenzyme (CK-MB) elevationMajor adverse clinical eventsCK-MB riseAdverse clinical eventsCoronary stentingLate mortalityClinical eventsGroup 1Group 3Group 2Long-term clinical importanceLong-term clinical eventsHospital recurrent ischemiaLate clinical outcomesCardiac enzyme elevationEvent-free survivalClinical end pointsHigher late mortalityPercutaneous coronary interventionPercutaneous coronary revascularizationCK-MB levelsNative coronary arteriesSuccessful coronary stentingSuccessful stent implantation