2006
Usefulness of Routine Unfractionated Heparin Infusion Following Primary Percutaneous Coronary Intervention for Acute Myocardial Infarction in Patients Not Receiving Glycoprotein IIb/IIIa Inhibitors
Harjai KJ, Stone GW, Grines CL, Cox DA, Garcia E, Tcheng JE, Na Y, Griffin JJ, Guagliumi G, Stuckey T, Turco M, Rutherford BD, Lansky AJ, Mehran R. Usefulness of Routine Unfractionated Heparin Infusion Following Primary Percutaneous Coronary Intervention for Acute Myocardial Infarction in Patients Not Receiving Glycoprotein IIb/IIIa Inhibitors. The American Journal Of Cardiology 2006, 99: 202-207. PMID: 17223419, DOI: 10.1016/j.amjcard.2006.07.084.Peer-Reviewed Original ResearchConceptsPercutaneous transluminal coronary angioplastyPrimary percutaneous coronary interventionGlycoprotein IIb/IIIa inhibitorsIIb/IIIa inhibitorsAcute myocardial infarctionPercutaneous coronary interventionHeparin usePostprocedural heparinCoronary interventionMyocardial infarctionHospital major adverse cardiac eventsPrimary PCIMajor adverse cardiac eventsUnfractionated heparin infusionAdverse cardiac eventsOutcomes of patientsSubset of patientsTransluminal coronary angioplastyLate MACEPostprocedure courseHeparin infusionCardiac eventsCoronary angioplastyCoronary stentingSevere bleedingImpact of treatment delays on outcomes of primary percutaneous coronary intervention for acute myocardial infarction: Analysis from the CADILLAC trial
Brodie BR, Stone GW, Cox DA, Stuckey TD, Turco M, Tcheng JE, Berger P, Mehran R, McLaughlin M, Costantini C, Lansky AJ, Grines CL. Impact of treatment delays on outcomes of primary percutaneous coronary intervention for acute myocardial infarction: Analysis from the CADILLAC trial. American Heart Journal 2006, 151: 1231-1238. PMID: 16781224, DOI: 10.1016/j.ahj.2005.07.016.Peer-Reviewed Original ResearchConceptsPrimary percutaneous coronary interventionPercutaneous coronary interventionAcute myocardial infarctionLow-risk patientsLeft ventricular functionOnset of symptomsTreatment delayCoronary interventionEarly reperfusionMyocardial infarctionCADILLAC trialVentricular functionComplete ST-segment resolutionPercutaneous transluminal coronary angioplastyFrequent grade 2ST-segment resolutionHigh-risk patientsSuperior clinical outcomesTransluminal coronary angioplastyMicrovascular reperfusionBalloon timeCoronary angioplastyClinical outcomesMyocardial blushPatient triage
2005
Impact of smoking status on outcomes of primary coronary intervention for acute myocardial infarction—The smoker's paradox revisited
Weisz G, Cox DA, Garcia E, Tcheng JE, Griffin JJ, Guagliumi G, Stuckey TD, Rutherford BD, Mehran R, Aymong E, Lansky A, Grines CL, Stone GW. Impact of smoking status on outcomes of primary coronary intervention for acute myocardial infarction—The smoker's paradox revisited. American Heart Journal 2005, 150: 358-364. PMID: 16086943, DOI: 10.1016/j.ahj.2004.01.032.Peer-Reviewed Original ResearchMeSH KeywordsAbciximabAgedAngioplasty, Balloon, CoronaryAntibodies, MonoclonalAnticoagulantsComorbidityCoronary AngiographyFemaleFollow-Up StudiesHumansImmunoglobulin Fab FragmentsMaleMiddle AgedMortalityMyocardial InfarctionPlatelet Aggregation InhibitorsProspective StudiesRecurrenceRiskSmokingSmoking CessationStentsStrokeSurvival AnalysisTreatment OutcomeConceptsAcute myocardial infarctionSmoking statusCurrent smokersSmoker's paradoxCoronary interventionFormer smokersCigarette smokingMyocardial infarctionPrior acute myocardial infarctionPrimary percutaneous coronary interventionPercutaneous transluminal coronary angioplastyTriple-vessel coronary diseaseMechanical reperfusion therapyPrimary coronary interventionProcedural success ratePercutaneous coronary interventionTransluminal coronary angioplastyAge-adjusted riskCurrent smoking statusOccurrence of AMITime of presentationLower mortality rateCADILLAC trialLate mortalityPrimary PCI
2003
Outcomes of optimal or “stent-like”balloon angioplasty in acutemyocardial infarction: the CADILLAC trial
Cox DA, Stone GW, Grines CL, Stuckey T, Cohen DJ, Tcheng JE, Garcia E, Guagliumi G, Iwaoka RS, Fahy M, Turco M, Lansky AJ, Griffin JJ, Mehran R, Investigators C. Outcomes of optimal or “stent-like”balloon angioplasty in acutemyocardial infarction: the CADILLAC trial. Journal Of The American College Of Cardiology 2003, 42: 971-977. PMID: 13678914, DOI: 10.1016/s0735-1097(03)00911-2.Peer-Reviewed Original ResearchConceptsPercutaneous transluminal coronary angioplastyAcute myocardial infarctionTarget vessel revascularizationIschemic target vessel revascularizationRoutine stentingRoutine stent placementStent implantationStent placementPrimary percutaneous transluminal coronary angioplastyComposite adverse event rateLate Angioplasty Complications (CADILLAC) trialRoutine stent implantationAdverse event ratesTransluminal coronary angioplastyRelevant treatment modalitiesRate of deathCADILLAC trialControlled AbciximabEligible lesionsAngiographic restenosisVessel revascularizationComplications TrialCoronary angioplastyDiameter stenosisPTCA results
2002
Comparison of Angioplasty with Stenting, with or without Abciximab, in Acute Myocardial Infarction
Stone GW, Grines CL, Cox DA, Garcia E, Tcheng JE, Griffin JJ, Guagliumi G, Stuckey T, Turco M, Carroll JD, Rutherford BD, Lansky AJ. Comparison of Angioplasty with Stenting, with or without Abciximab, in Acute Myocardial Infarction. New England Journal Of Medicine 2002, 346: 957-966. PMID: 11919304, DOI: 10.1056/nejmoa013404.Peer-Reviewed Original ResearchMeSH KeywordsAbciximabAdultAgedAged, 80 and overAngioplasty, Balloon, CoronaryAntibodies, MonoclonalCombined Modality TherapyCoronary AngiographyFemaleHumansImmunoglobulin Fab FragmentsMaleMiddle AgedMyocardial InfarctionMyocardial ReperfusionPlatelet Aggregation InhibitorsPlatelet Glycoprotein GPIIb-IIIa ComplexProspective StudiesRecurrenceStentsStrokeConceptsPrimary percutaneous transluminal coronary angioplastyAcute myocardial infarctionPercent of patientsPrimary end pointInfarct-related arteryRate of deathMyocardial infarctionAbciximab therapyReperfusion strategyPlatelet glycoprotein IIb/IIIa inhibitorsGlycoprotein IIb/IIIa inhibitorsTarget vesselIIb/IIIa inhibitorsPercutaneous transluminal coronary angioplastyEnd pointComposite of deathTarget vessel revascularizationIschemia-driven revascularizationTransluminal coronary angioplastyComparison of AngioplastyAbciximab useRecurrent ischemiaExperienced centersCoronary angioplastyCoronary stentingDevice selection in the treatment of in-stent restenosis with and without radiation (from the Gamma Radiation Trials)
Ajani AE, Waksman R, Zimarino M, Kim H, Pichard AD, Satler LF, Kent KM, White RL, Pinnow E, Mehran R, Lansky A, Lindsay J. Device selection in the treatment of in-stent restenosis with and without radiation (from the Gamma Radiation Trials). The American Journal Of Cardiology 2002, 89: 137-144. PMID: 11792331, DOI: 10.1016/s0002-9149(01)02189-0.Peer-Reviewed Original ResearchMeSH KeywordsAgedAnalysis of VarianceAngioplastyAngioplasty, Balloon, CoronaryChi-Square DistributionCoronary DiseaseDose-Response Relationship, RadiationFemaleHumansIridium RadioisotopesLogistic ModelsMaleMiddle AgedProspective StudiesRisk FactorsSecondary PreventionStentsTreatment OutcomeVascular PatencyConceptsExcimer laser coronary angioplastyMajor adverse coronary eventsAdditional stent implantationTreatment of ISRRecurrence rateCoronary angioplastyRotational atherectomyStent implantationStent restenosisBalloon percutaneous transluminal coronary angioplastyPercutaneous transluminal coronary angioplastyIntracoronary gamma radiationLate clinical outcomesAdverse coronary eventsOverall recurrence rateTransluminal coronary angioplastyLaser coronary angioplastyHigh recurrence rateUse of stentingDevice selectionAngiographic characteristicsMACE ratePlacebo groupPlacebo therapyCoronary events
2001
Importance of time to reperfusion on outcomes with primary coronary angioplasty for acute myocardial infarction (results from the Stent Primary Angioplasty in Myocardial Infarction Trial)
Brodie B, Stone G, Morice M, Cox D, Garcia E, Mattos L, Boura J, O’Neill W, Stuckey T, Milks S, Lansky A, Grines C, Group F. Importance of time to reperfusion on outcomes with primary coronary angioplasty for acute myocardial infarction (results from the Stent Primary Angioplasty in Myocardial Infarction Trial). The American Journal Of Cardiology 2001, 88: 1085-1090. PMID: 11703949, DOI: 10.1016/s0002-9149(01)02039-2.Peer-Reviewed Original ResearchConceptsPrimary percutaneous transluminal coronary angioplastyPrimary PTCAAcute myocardial infarctionCardiogenic shockCoronary angioplastyMyocardial infarctionMyocardial Infarction (TIMI) grade 3 flowPercutaneous transluminal coronary angioplastyInfarct artery reocclusionStent-PAMI trialGrade 3 flowPrimary coronary angioplastyTransluminal coronary angioplastyTriage of patientsArtery reocclusionMortality benefitSurvival benefitEjection fractionLate reperfusionClinical outcomesMyocardial salvageThrombolytic therapyReperfusionPatientsLack of correlationTreatment of focal in-stent restenosis with balloon angioplasty alone versus stenting: Short- and long-term results
Mehran R, Dangas G, Abizaid A, Lansky A, Mintz G, Pichard A, Satler L, Kent K, Waksman R, Stone G, Leon M. Treatment of focal in-stent restenosis with balloon angioplasty alone versus stenting: Short- and long-term results. American Heart Journal 2001, 141: 610-614. PMID: 11275928, DOI: 10.1067/mhj.2001.113998.Peer-Reviewed Original ResearchConceptsPercutaneous transluminal coronary angioplastyMinimal lumen diameterLong-term clinical resultsFocal ISRStent groupClinical resultsStent restenosisLarger reference vessel diameterLesion lengthLesion revascularization rateTarget lesion revascularizationReference vessel diameterResidual diameter stenosisTransluminal coronary angioplastyLong-term resultsQ-wave infarctionPTCA groupUrgent revascularizationAngiographic successLesion revascularizationRevascularization ratesAdditional stentingBaseline characteristicsCoronary angioplastyDiabetic patients
2000
Intracoronary β-Radiation Therapy Inhibits Recurrence of In-Stent Restenosis
Waksman R, Bhargava B, White L, Chan R, Mehran R, Lansky A, Mintz G, Satler L, Pichard A, Leon M, Kent K. Intracoronary β-Radiation Therapy Inhibits Recurrence of In-Stent Restenosis. Circulation 2000, 101: 1895-1898. PMID: 10779453, DOI: 10.1161/01.cir.101.16.1895.Peer-Reviewed Original ResearchConceptsRevascularization ratesBinary angiographic restenosis rateIntracoronary gamma radiation therapyTarget vessel revascularization rateTarget lesion revascularization ratePercutaneous transluminal coronary angioplastyVessel revascularization rateAngiographic restenosis rateLesion revascularization rateTransluminal coronary angioplastyIn-Stent RestenosisGamma radiation therapyRecurrent ISRPlacebo groupClinical restenosisAdjunct therapyConsecutive patientsCoronary angioplastyRestenosis rateRotational atherectomyStent implantationBalloon catheterNative coronariesStent restenosisPatients
1999
Long-Term Follow-Up After Percutaneous Transluminal Coronary Angioplasty Was Not Performed Based on Intravascular Ultrasound Findings
Abizaid A, Mintz G, Mehran R, Abizaid A, Lansky A, Pichard A, Satler L, Wu H, Pappas C, Kent K, Leon M. Long-Term Follow-Up After Percutaneous Transluminal Coronary Angioplasty Was Not Performed Based on Intravascular Ultrasound Findings. Circulation 1999, 100: 256-261. PMID: 10411849, DOI: 10.1161/01.cir.100.3.256.Peer-Reviewed Original ResearchConceptsMinimum lumen areaIntravascular ultrasound findingsOnly independent predictorLumen areaIVUS minimum lumen areaEvent ratesDiabetes mellitusIndependent predictorsUltrasound findingsIVUS parametersArea stenosisLumen diameterPercutaneous transluminal coronary angioplastyLesion lumen areaNative artery lesionsTarget lesion revascularizationTransluminal coronary angioplastyCoronary artery stenosisMinimum lumen diameterLow event ratesArtery lesionsCardiac deathCoronary angioplastyArtery stenosisPlaque burdenTwo-year follow-up after intracoronary gamma radiation therapy
Condado J, Waksman R, Calderas C, Saucedo J, Lansky A. Two-year follow-up after intracoronary gamma radiation therapy. Cardiovascular Revascularization Medicine 1999, 1: 30-35. PMID: 11272353, DOI: 10.1016/s1522-1865(98)00014-6.Peer-Reviewed Original ResearchConceptsPercutaneous transluminal coronary angioplastyIntracoronary gamma radiation therapyGamma radiation therapyRadiation therapyBinary restenosisAngiographic binary restenosisMean late lossLate luminal lossTransluminal coronary angioplastyEndovascular revascularization proceduresAngiographic complicationsEarly pseudoaneurysmRestenosis indexAngiographic outcomesLate complicationsCoronary angioplastyRevascularization proceduresLuminal lossLate aneurysmSpontaneous regressionUnfavorable remodelingSerial angiographyLate effectsLate lossLong-term effects