2012
Impact of the Presence and Extent of Incomplete Angiographic Revascularization After Percutaneous Coronary Intervention in Acute Coronary Syndromes
Rosner GF, Kirtane AJ, Genereux P, Lansky AJ, Cristea E, Gersh BJ, Weisz G, Parise H, Fahy M, Mehran R, Stone GW. Impact of the Presence and Extent of Incomplete Angiographic Revascularization After Percutaneous Coronary Intervention in Acute Coronary Syndromes. Circulation 2012, 125: 2613-2620. PMID: 22550156, DOI: 10.1161/circulationaha.111.069237.Peer-Reviewed Original ResearchConceptsMajor adverse cardiac eventsIncomplete coronary revascularizationPercutaneous coronary interventionAdverse cardiac eventsAcute coronary syndromeCoronary interventionCoronary syndromeCardiac eventsUnplanned revascularizationMyocardial infarctionMajor adverse cardiac event ratesUrgent Intervention Triage Strategy (ACUITY) trialAdverse cardiac event ratesCardiac event rateReference vessel diameterEntire coronary treeAcute CatheterizationAngiographic revascularizationCoronary revascularizationIndependent predictorsPrimary outcomeMultivariable analysisStrategy trialQuantitative angiographyClinical significance
2011
Incidence and clinical consequences of acquired thrombocytopenia after antithrombotic therapies in patients with acute coronary syndromes: Results from the Acute Catheterization and Urgent Intervention Triage Strategy (ACUITY) trial
Caixeta A, Dangas GD, Mehran R, Feit F, Nikolsky E, Lansky AJ, Aoki J, Moses JW, Steinhubl SR, White HD, Ohman EM, Manoukian SV, Fahy M, Stone GW. Incidence and clinical consequences of acquired thrombocytopenia after antithrombotic therapies in patients with acute coronary syndromes: Results from the Acute Catheterization and Urgent Intervention Triage Strategy (ACUITY) trial. American Heart Journal 2011, 161: 298-306.e1. PMID: 21315212, DOI: 10.1016/j.ahj.2010.10.035.Peer-Reviewed Original ResearchConceptsIIb/IIIa inhibitorsGP IIb/IIIa inhibitorsAcute coronary syndromeBivalirudin monotherapyMajor bleedingCoronary syndromePlatelet countClinical consequencesUrgent Intervention Triage Strategy (ACUITY) trialGlycoprotein IIb/IIIa inhibitorsPredictors of mortalityAcquired thrombocytopeniaACUITY trialAcute CatheterizationAntiplatelet medicationsAntithrombotic therapyIschemic complicationsAnticoagulant regimenIndependent predictorsStrategy trialThrombocytopeniaPatientsMultivariate analysisMonotherapyLess decline
2010
Response to Letter Regarding Article, “Prognostic Modeling of Individual Patient Risk and Mortality Impact of Ischemic and Hemorrhagic Complications: Assessment From the Acute Catheterization and Urgent Intervention Triage Strategy Trial”
Stone G, Mehran R, Nikolsky E, Parise H, Fahy M, Lansky A, Moses J, Pocock S, Clayton T, Bertrand M, Lincoff A, Ohman E, White H. Response to Letter Regarding Article, “Prognostic Modeling of Individual Patient Risk and Mortality Impact of Ischemic and Hemorrhagic Complications: Assessment From the Acute Catheterization and Urgent Intervention Triage Strategy Trial”. Circulation 2010, 122: e462-e463. DOI: 10.1161/circulationaha.110.951897.Peer-Reviewed Original ResearchIMPACT OF LEFT VENTRICULAR FUNCTION ON MORTALITY IN PATIENTS WITH ACUTE CORONARY SYNDROMES: ANALYSIS OF THE ACUTE CATHETERIZATION AND URGENT INTERVENTION TRIAGE STRATEGY (ACUITY) TRIAL
Lansky A, Ng V, Goto K, Fahy M, Mehran R, Ebrahimian R, Hamond M, Ohman E, Feit F, Manoukian S, Lincoff M, Stone G. IMPACT OF LEFT VENTRICULAR FUNCTION ON MORTALITY IN PATIENTS WITH ACUTE CORONARY SYNDROMES: ANALYSIS OF THE ACUTE CATHETERIZATION AND URGENT INTERVENTION TRIAGE STRATEGY (ACUITY) TRIAL. Journal Of The American College Of Cardiology 2010, 55: a186.e1740. DOI: 10.1016/s0735-1097(10)61741-x.Peer-Reviewed Original Research
2009
Prognostic Modeling of Individual Patient Risk and Mortality Impact of Ischemic and Hemorrhagic Complications
Pocock SJ, Mehran R, Clayton TC, Nikolsky E, Parise H, Fahy M, Lansky AJ, Bertrand ME, Lincoff AM, Moses JW, Ohman EM, White HD, Stone GW. Prognostic Modeling of Individual Patient Risk and Mortality Impact of Ischemic and Hemorrhagic Complications. Circulation 2009, 121: 43-51. PMID: 20026777, DOI: 10.1161/circulationaha.109.878017.Peer-Reviewed Original ResearchMeSH KeywordsAcute Coronary SyndromeAgedAged, 80 and overFemaleFibrinolytic AgentsHemorrhageHeparinHirudinsHumansLogistic ModelsMaleMiddle AgedMultivariate AnalysisMyocardial InfarctionMyocardial IschemiaPeptide FragmentsPlatelet Glycoprotein GPIIb-IIIa ComplexPredictive Value of TestsPrognosisRandomized Controlled Trials as TopicRecombinant ProteinsRetrospective StudiesRisk FactorsConceptsGlycoprotein IIb/IIIa inhibitorsIIb/IIIa inhibitorsIndividual patient risk profileAcute coronary syndromePatient risk profileMajor bleedingMyocardial infarctionCoronary syndromeRisk profileHemorrhagic complicationsIndependent predictorsMortality rateUrgent Intervention Triage Strategy (ACUITY) trialAlternative antithrombotic regimensIndividual patient's riskRisk of deathCox regression modelTherapy of patientsSubsequent mortality ratesRelative treatment effectsAcute CatheterizationAntithrombotic regimensMajor bleedsAlternative pharmacotherapyStrategy trialAssociations of major bleeding and myocardial infarction with the incidence and timing of mortality in patients presenting with non-ST-elevation acute coronary syndromes: a risk model from the ACUITY trial
Mehran R, Pocock SJ, Stone GW, Clayton TC, Dangas GD, Feit F, Manoukian SV, Nikolsky E, Lansky AJ, Kirtane A, White HD, Colombo A, Ware JH, Moses JW, Ohman EM. Associations of major bleeding and myocardial infarction with the incidence and timing of mortality in patients presenting with non-ST-elevation acute coronary syndromes: a risk model from the ACUITY trial. European Heart Journal 2009, 30: 1457-1466. PMID: 19351691, PMCID: PMC2695951, DOI: 10.1093/eurheartj/ehp110.Peer-Reviewed Original ResearchConceptsAcute coronary syndromeMajor bleedingMyocardial infarctionBaseline predictorsMortality riskMajor bleedsCoronary syndromeHigh-risk acute coronary syndromesUrgent Intervention Triage Strategy (ACUITY) trialElevation acute coronary syndromeMultivariable Cox regression modelsDays of randomizationTime-updated covariatesRecurrent myocardial infarctionIndependent baseline predictorsCox regression modelShort-term riskTiming of mortalityACUITY trialAcute CatheterizationHazard ratioStrategy trialBleedingMortality hazardCox model
2007
Bivalirudin in patients with acute coronary syndromes undergoing percutaneous coronary intervention: a subgroup analysis from the Acute Catheterization and Urgent Intervention Triage strategy (ACUITY) trial
Stone GW, White HD, Ohman EM, Bertrand ME, Lincoff AM, McLaurin BT, Cox DA, Pocock SJ, Ware JH, Feit F, Colombo A, Manoukian SV, Lansky AJ, Mehran R, Moses JW, investigators F. Bivalirudin in patients with acute coronary syndromes undergoing percutaneous coronary intervention: a subgroup analysis from the Acute Catheterization and Urgent Intervention Triage strategy (ACUITY) trial. The Lancet 2007, 369: 907-919. PMID: 17368152, DOI: 10.1016/s0140-6736(07)60450-4.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAngioplasty, Balloon, CoronaryAnticoagulantsCombined Modality TherapyDrug Therapy, CombinationEnoxaparinFemaleHeparinHirudinsHumansMaleMiddle AgedMyocardial IschemiaPeptide FragmentsPlatelet Aggregation InhibitorsPlatelet Glycoprotein GPIIb-IIIa ComplexProspective StudiesRecombinant ProteinsTreatment OutcomeConceptsGlycoprotein IIb/IIIa inhibitorsIIb/IIIa inhibitorsPercutaneous coronary interventionAcute coronary syndromeNet clinical outcomeHigh-risk acute coronary syndromesUrgent Intervention Triage Strategy (ACUITY) trialCoronary interventionClinical outcomesMajor bleedingCoronary syndromeAcute CatheterizationStrategy trialDirect thrombin inhibitor bivalirudinAdverse ischemic eventsMajor haemorrhagic complicationsComparable clinical outcomesThrombin inhibitor bivalirudinHaemorrhagic complicationsIschemic eventsUnfractionated heparinSubgroup analysisProportion of individualsBivalirudinBleeding
2004
Acute Catheterization and Urgent Intervention Triage strategY (ACUITY) trial: Study design and rationale
Stone GW, Bertrand M, Colombo A, Dangas G, Farkouh ME, Feit F, Lansky AJ, Lincoff AM, Mehran R, Moses JW, Ohman M, White HD. Acute Catheterization and Urgent Intervention Triage strategY (ACUITY) trial: Study design and rationale. American Heart Journal 2004, 148: 764-775. PMID: 15523305, DOI: 10.1016/j.ahj.2004.04.036.Peer-Reviewed Original ResearchMeSH KeywordsAngina, UnstableAngioplasty, Balloon, CoronaryAnticoagulantsAntithrombinsCardiac CatheterizationCombined Modality TherapyCoronary Artery BypassEnoxaparinHeparinHirudinsHumansMulticenter Studies as TopicMyocardial InfarctionPeptide FragmentsPlatelet Glycoprotein GPIIb-IIIa ComplexProspective StudiesRandomized Controlled Trials as TopicRecombinant ProteinsResearch DesignConceptsIIb/IIIa inhibitionUrgent Intervention Triage Strategy (ACUITY) trialIIb/IIIa inhibitorsAcute CatheterizationInhibitor administrationStrategy trialMyocardial infarctionGlycoprotein IIb/IIIa inhibitorsPrimary study end pointAdverse ischemic eventsHigh-risk ACSComposite of deathStudy end pointAcute coronary syndromeHigh-risk patientsSurgical revascularization proceduresTreatment of choiceSecond random assignmentACUITY trialMajor bleedingSurgical revascularizationUnplanned revascularizationCoronary syndromeEarly angiographyIschemic events