2017
What is the best ST-segment recovery parameter to predict clinical outcome and myocardial infarct size? Amplitude, speed, and completeness of ST-segment recovery after primary percutaneous coronary intervention for ST-segment elevation myocardial infarction
Kuijt WJ, Green CL, Verouden NJW, Haeck JDE, Tzivoni D, Koch KT, Stone GW, Lansky AJ, Broderick S, Tijssen JGP, de Winter RJ, Roe MT, Krucoff MW. What is the best ST-segment recovery parameter to predict clinical outcome and myocardial infarct size? Amplitude, speed, and completeness of ST-segment recovery after primary percutaneous coronary intervention for ST-segment elevation myocardial infarction. Journal Of Electrocardiology 2017, 50: 952-959. PMID: 29153151, DOI: 10.1016/j.jelectrocard.2017.04.009.Peer-Reviewed Original ResearchConceptsST-segment elevation myocardial infarctionST-segment recoveryPrimary percutaneous coronary interventionPercutaneous coronary interventionElevation myocardial infarctionInfarct sizeCoronary interventionMyocardial infarctionHolter ECG monitoringMyocardial infarct sizeSingle photon emissionMultivariable adjustmentClinical outcomesRisk factorsClinical trialsNoninvasive biomarkersCore laboratoryMechanistic correlatesMortalityECG monitoringInfarctionRecovery parametersST parametersInterventionOutcomes
2014
Implications of ventricular arrhythmia “bursts” with normal epicardial flow, myocardial blush, and ST-segment recovery in anterior ST-elevation myocardial infarction reperfusion: A biosignature of direct myocellular injury “downstream of downstream”
Majidi M, Kosinski AS, Al-Khatib SM, Smolders L, Cristea E, Lansky AJ, Stone GW, Mehran R, Gibbons RJ, Crijns HJ, Wellens HJ, Gorgels AP, Krucoff MW. Implications of ventricular arrhythmia “bursts” with normal epicardial flow, myocardial blush, and ST-segment recovery in anterior ST-elevation myocardial infarction reperfusion: A biosignature of direct myocellular injury “downstream of downstream”. European Heart Journal Acute Cardiovascular Care 2014, 4: 51-59. PMID: 25063574, DOI: 10.1177/2048872614532414.Peer-Reviewed Original ResearchConceptsST-segment recoveryMyocardial blush gradeST-segment elevation myocardial infarctionNormal epicardial flowTIMI 3 flowPercutaneous coronary interventionEpicardial flowLarger ISOptimal reperfusionVentricular arrhythmiasMyocellular injuryFinal TIMI 3 flowMyocardial Infarction 3 flowAnterior STEMI patientsElevation myocardial infarctionReperfusion ventricular arrhythmiasInfarct size assessmentMyocardial infarction reperfusionContinuous ECG monitoringMBG 2/3Myocardial ISBlush gradeSTEMI patientsCoronary interventionMyocardial reperfusion
2010
QUANTIFICATION OF AMPLITUDE, SPEED AND COMPLETENESS OF ST-SEGMENT RECOVERY AFTER PRIMARY PERCUTANEOUS CORONARY INTERVENTION FOR ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION: WHAT IS THE “BEST ST” RECOVERY TO PREDICT CLINICAL OUTCOME?
Kuijt W, Roe M, Green C, Verouden N, Haeck J, Tzivoni D, Koch K, Stone G, Lansky A, De Winter R, Krucoff M. QUANTIFICATION OF AMPLITUDE, SPEED AND COMPLETENESS OF ST-SEGMENT RECOVERY AFTER PRIMARY PERCUTANEOUS CORONARY INTERVENTION FOR ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION: WHAT IS THE “BEST ST” RECOVERY TO PREDICT CLINICAL OUTCOME? Journal Of The American College Of Cardiology 2010, 55: a134.e1255. DOI: 10.1016/s0735-1097(10)61256-9.Peer-Reviewed Original Research
2007
Impact of collateral flow on myocardial reperfusion and infarct size in patients undergoing primary angioplasty for acute myocardial infarction
Sorajja P, Gersh BJ, Mehran R, Lansky AJ, Krucoff MW, Webb J, Cox DA, Brodie BR, Stone GW. Impact of collateral flow on myocardial reperfusion and infarct size in patients undergoing primary angioplasty for acute myocardial infarction. American Heart Journal 2007, 154: 379-384. PMID: 17643592, DOI: 10.1016/j.ahj.2007.04.034.Peer-Reviewed Original ResearchConceptsPrimary percutaneous coronary interventionPrimary PCIBaseline collateral flowInfarct-related arteryAcute myocardial infarctionCollateral flowInfarct sizeClinical outcomesMyocardial reperfusionReperfusion successMyocardial infarctionLess ST segment elevationMajor adverse cardiac eventsAdverse cardiac eventsSubsequent clinical outcomesPercutaneous coronary interventionST-segment elevationST-segment recoveryAcute proceduralEMERALD trialNonanterior infarctionPrimary angioplastyStable anginaArtery occlusionCardiac eventsImpact of multivessel disease on reperfusion success and clinical outcomes in patients undergoing primary percutaneous coronary intervention for acute myocardial infarction
Sorajja P, Gersh BJ, Cox DA, McLaughlin MG, Zimetbaum P, Costantini C, Stuckey T, Tcheng JE, Mehran R, Lansky AJ, Grines CL, Stone GW. Impact of multivessel disease on reperfusion success and clinical outcomes in patients undergoing primary percutaneous coronary intervention for acute myocardial infarction. European Heart Journal 2007, 28: 1709-1716. PMID: 17556348, DOI: 10.1093/eurheartj/ehm184.Peer-Reviewed Original ResearchConceptsPrimary PCIPrimary percutaneous coronary interventionMajor adverse cardiac eventsAcute myocardial infarctionCoronary artery diseaseTriple vessel diseasePercutaneous coronary interventionMultivessel diseaseST-segment recoveryReperfusion successCoronary interventionClinical outcomesMyocardial blushMyocardial infarctionPost-procedural TIMI 3 flowExtent of CADExtensive coronary artery diseaseMultivessel coronary artery diseaseAdverse cardiac eventsTIMI 3 flowInfarct-related arterySingle-vessel diseaseCADILLAC trialPost-PCIInfarct vessel
2005
Combined prognostic utility of ST-segment recovery and myocardial blush after primary percutaneous coronary intervention in acute myocardial infarction
Sorajja P, Gersh BJ, Costantini C, McLaughlin MG, Zimetbaum P, Cox DA, Garcia E, Tcheng JE, Mehran R, Lansky AJ, Kandzari DE, Grines CL, Stone GW. Combined prognostic utility of ST-segment recovery and myocardial blush after primary percutaneous coronary intervention in acute myocardial infarction. European Heart Journal 2005, 26: 667-674. PMID: 15734768, DOI: 10.1093/eurheartj/ehi167.Peer-Reviewed Original ResearchConceptsPrimary percutaneous coronary interventionAcute myocardial infarctionPrimary PCIPercutaneous coronary interventionST-segment recoveryMyocardial blushCoronary interventionMultivariable analysisPrognostic utilityMyocardial infarctionGreater prognostic utilityStrongest prognostic variableYear clinical outcomesIncremental prognostic informationCADILLAC trialReperfusion therapyReperfusion successClinical outcomesGrade 2/3Independent correlatesMicrocirculatory integrityPrognostic informationUnivariate analysisPoor survivalCumulative rate