2022
Impella Versus Intra-Aortic Balloon Pump for High-Risk PCI: A Propensity-Adjusted Large-Scale Claims Dataset Analysis
Lansky AJ, Tirziu D, Moses JW, Pietras C, Ohman EM, O'Neill WW, Ekono MM, Grines CL, Parise H. Impella Versus Intra-Aortic Balloon Pump for High-Risk PCI: A Propensity-Adjusted Large-Scale Claims Dataset Analysis. The American Journal Of Cardiology 2022, 185: 29-36. PMID: 36210212, DOI: 10.1016/j.amjcard.2022.08.032.Peer-Reviewed Original ResearchConceptsHigh-risk percutaneous coronary interventionIntra-aortic balloon pumpPercutaneous coronary interventionAcute kidney injuryCardiogenic shockMyocardial infarctionIABP supportKidney injuryBalloon pumpImproved survivalPropensity adjustmentAcute ST-elevation myocardial infarctionST-elevation myocardial infarctionIndex hospitalization lengthLess myocardial infarctionPremier Healthcare DatabaseHospital myocardial infarctionPropensity-adjusted analysisMechanical circulatory supportMechanical support devicesImpella useHospital survivalIndex hospitalizationCoronary interventionReal-world practiceST-Segment Elevation Myocardial Infarction: Sex Differences in Incidence, Etiology, Treatment, and Outcomes
Shah T, Kapadia S, Lansky AJ, Grines CL. ST-Segment Elevation Myocardial Infarction: Sex Differences in Incidence, Etiology, Treatment, and Outcomes. Current Cardiology Reports 2022, 24: 529-540. PMID: 35286662, DOI: 10.1007/s11886-022-01676-7.Peer-Reviewed Original ResearchConceptsST-elevation myocardial infarctionMyocardial infarctionMechanical circulatory supportStandard of careSex-based disparitiesEvidence-based strategiesEarly revascularizationCirculatory supportPoor outcomeWorse outcomesYoung womenStandardized protocolWomenOutcomesInfarctionTreatmentEtiologySex differencesHeterogeneous entityRevascularizationPatientsDisparitiesPurposeAlthoughIncidence
2021
The influence of biological age and sex on long-term outcome after percutaneous coronary intervention for ST-elevation myocardial infarction.
Rathod KS, Jones DA, Jain AK, Lim P, MacCarthy PA, Rakhit R, Lockie T, Kalra S, Dalby MC, Malik IS, Whitbread M, Firoozi S, Bogle R, Redwood S, Cooper J, Gupta A, Lansky A, Wragg A, Mathur A, Ahluwalia A. The influence of biological age and sex on long-term outcome after percutaneous coronary intervention for ST-elevation myocardial infarction. Am J Cardiovasc Dis 2021, 11: 659-678. PMID: 34849299, PMCID: PMC8611266.Peer-Reviewed Original ResearchST-segment elevation myocardial infarctionCause mortalityFemale sexCox analysisMyocardial infarctionST-elevation myocardial infarctionAge-matched menObservational cohort studyElevation myocardial infarctionPercutaneous coronary interventionKaplan-Meier analysisLong-term outcomesProportional hazards modelSub-group analysisHigh mortality rateYears of agePost-PCIPrimary PCICoronary interventionSTEMI patientsCohort studyMultivariate adjustmentPrimary outcomeUnivariate predictorsMenopausal years
2018
Targeted therapy with a localised abluminal groove, low-dose sirolimus-eluting, biodegradable polymer coronary stent (TARGET All Comers): a multicentre, open-label, randomised non-inferiority trial
Lansky A, Wijns W, Xu B, Kelbæk H, van Royen N, Zheng M, Morel MA, Knaapen P, Slagboom T, Johnson TW, Vlachojannis G, Arkenbout KE, Holmvang L, Janssens L, Ochala A, Brugaletta S, Naber CK, Anderson R, Rittger H, Berti S, Barbato E, Toth GG, Maillard L, Valina C, Buszman P, Thiele H, Schächinger V, Baumbach A, Investigators T. Targeted therapy with a localised abluminal groove, low-dose sirolimus-eluting, biodegradable polymer coronary stent (TARGET All Comers): a multicentre, open-label, randomised non-inferiority trial. The Lancet 2018, 392: 1117-1126. PMID: 30190206, DOI: 10.1016/s0140-6736(18)31649-0.Peer-Reviewed Original ResearchConceptsLate lumen lossStent late lumen lossTarget lesion failureCoronary artery diseaseNon-inferiority trialXience groupPrimary endpointLesion failureLumen lossAbluminal grooveAngiographic substudyComers populationArtery diseaseMyocardial ischaemiaMyocardial infarctionIschaemia-driven target lesion revascularisationAsymptomatic coronary artery diseaseTarget vessel myocardial infarctionIschemic coronary artery diseaseST-elevation myocardial infarctionRandom block allocationTarget lesion revascularisationStent thrombosis ratesVessel myocardial infarctionElevation myocardial infarction
2015
Will this trial change my practice? TOTAL: a randomised trial of thrombus aspiration in ST-elevation myocardial infarction.
Behan MW, Haude M, Oldroyd KG, Lansky AJ, James S, Baumbach A. Will this trial change my practice? TOTAL: a randomised trial of thrombus aspiration in ST-elevation myocardial infarction. EuroIntervention 2015, 11: 361-3. PMID: 26196756, DOI: 10.4244/eijv11i3a70.Peer-Reviewed Original Research
2014
Almanac 2013: acute coronary syndromes
Meier P, Lansky AJ, Baumbach A. Almanac 2013: acute coronary syndromes. Wiener Klinische Wochenschrift 2014, 126: 176-183. PMID: 24622880, DOI: 10.1007/s00508-014-0526-4.Peer-Reviewed Original ResearchST-elevation myocardial infarctionAcute coronary syndromeCoronary syndromeCardiac arrestUnstable coronary artery plaqueRecent therapeutic progressElevation myocardial infarctionNovel antiplatelet agentsCoronary artery plaquesSudden cardiac arrestCommon underlying causeACS mortalityElevation infarctionUnstable anginaAntiplatelet agentsArtery plaquesMyocardial infarctionTherapeutic progressUnderlying causeInfarctionSyndromeArrestAnginaPrasugrelCangrelorAlmanac 2013: acute coronary syndromes
Meier P, Lansky AJ, Baumbach A. Almanac 2013: acute coronary syndromes. The Anatolian Journal Of Cardiology 2014 PMID: 24566518, DOI: 10.5152/akd.2014.5552014.Peer-Reviewed Original ResearchST-elevation myocardial infarctionAcute coronary syndromeCoronary syndromeCardiac arrestUnstable coronary artery plaqueRecent therapeutic progressElevation myocardial infarctionNovel antiplatelet agentsCoronary artery plaquesSudden cardiac arrestCommon underlying causeACS mortalityElevation infarctionUnstable anginaAntiplatelet agentsArtery plaquesMyocardial infarctionTherapeutic progressUnderlying causeInfarctionSyndromeArrestAnginaPrasugrelCangrelorEsc
Meier P, Lansky AJ, Baumbach A. Esc. Acta Cardiologica 2014, 69: 100-108. PMID: 24640527, DOI: 10.1080/ac.69.1.3011351.Peer-Reviewed Original ResearchMeSH KeywordsAcute Coronary SyndromeDeath, Sudden, CardiacElectrocardiographyHumansMonitoring, PhysiologicMyocardial InfarctionOutcome Assessment, Health CarePercutaneous Coronary InterventionPlatelet Aggregation InhibitorsTime-to-TreatmentTomography, Optical CoherenceUltrasonography, InterventionalConceptsST-elevation myocardial infarctionAcute coronary syndromeCardiac arrestUnstable coronary artery plaqueRecent therapeutic progressElevation myocardial infarctionNovel antiplatelet agentsCoronary artery plaquesSudden cardiac arrestCommon underlying causeACS mortalityElevation infarctionCoronary syndromeUnstable anginaAntiplatelet agentsArtery plaquesMyocardial infarctionTherapeutic progressUnderlying causeInfarctionArrestAnginaCangrelorPrasugrelTicagrelorAlmanac 2013: Acute coronary syndromes the national society journals present selected research that has driven recent advances in clinical cardiology
Meier P, Lansky A, Baumbach A. Almanac 2013: Acute coronary syndromes the national society journals present selected research that has driven recent advances in clinical cardiology. Srce I Krvni Sudovi 2014, 33: 254-260. DOI: 10.5937/siks1404254m.Peer-Reviewed Original ResearchST-elevation myocardial infarctionAcute coronary syndromeCardiac arrestUnstable coronary artery plaqueRecent therapeutic progressElevation myocardial infarctionNovel antiplatelet agentsCoronary artery plaquesSudden cardiac arrestCommon underlying causeACS mortalityElevation infarctionCoronary syndromeUnstable anginaAntiplatelet agentsNational society journalsArtery plaquesMyocardial infarctionTherapeutic progressUnderlying causeClinical cardiologyInfarctionArrestAnginaPrasugrel
2013
Almanac 2013: acute coronary syndromes
Meier P, Lansky A, Baumbach A. Almanac 2013: acute coronary syndromes. Seminars In Cardiovascular Medicine 2013, 19: 30-38. DOI: 10.2478/semcard-2013-0005.Peer-Reviewed Original ResearchST-elevation myocardial infarctionAcute coronary syndromeCoronary syndromeCardiac arrestUnstable coronary artery plaqueRecent therapeutic progressElevation myocardial infarctionNovel antiplatelet agentsCoronary artery plaquesSudden cardiac arrestCommon underlying causeACS mortalityElevation infarctionUnstable anginaAntiplatelet agentsArtery plaquesMyocardial infarctionTherapeutic progressUnderlying causeInfarctionSyndromeArrestAnginaPrasugrelCangrelorAlmanac 2013: acute coronary syndromes.
Meier P, Lansky AJ, Baumbach A. Almanac 2013: acute coronary syndromes. Turk Kardiyoloji Dernegi Arsivi-Archives Of The Turkish Society Of Cardiology 2013, 41: 755-64. PMID: 24351954, DOI: 10.5543/tkda.2013..Peer-Reviewed Original ResearchConceptsST-elevation myocardial infarctionCardiac arrestUnstable coronary artery plaqueRecent therapeutic progressAcute coronary syndromeElevation myocardial infarctionNovel antiplatelet agentsCoronary artery plaquesSudden cardiac arrestCommon underlying causeACS mortalityElevation infarctionCoronary syndromeUnstable anginaAntiplatelet agentsArtery plaquesMyocardial infarctionTherapeutic progressUnderlying causeInfarctionArrestAnginaPrasugrelCangrelorTicagrelorAlmanac 2013: acute coronary syndromes
Meier P, Lansky AJ, Baumbach A. Almanac 2013: acute coronary syndromes. The Anatolian Journal Of Cardiology 2013, 13: 825-32. PMID: 24108759, DOI: 10.5152/akd.2013.238.Peer-Reviewed Original ResearchConceptsST-elevation myocardial infarctionAcute coronary syndromeCoronary syndromeCardiac arrestUnstable coronary artery plaqueRecent therapeutic progressElevation myocardial infarctionNovel antiplatelet agentsCoronary artery plaquesSudden cardiac arrestCommon underlying causeACS mortalityElevation infarctionUnstable anginaAntiplatelet agentsArtery plaquesMyocardial infarctionTherapeutic progressUnderlying causeInfarctionSyndromeArrestAnginaPrasugrelCangrelorComplementary prognostic utility of myocardial blush grade and ST-segment resolution after primary percutaneous coronary intervention: Analysis from the HORIZONS-AMI trial
Brener SJ, Dizon JM, Mehran R, Guerchicoff A, Lansky AJ, Farkouh M, Brodie B, Guagliumi G, Witzenbichler B, Fahy M, Parise H, Stone GW. Complementary prognostic utility of myocardial blush grade and ST-segment resolution after primary percutaneous coronary intervention: Analysis from the HORIZONS-AMI trial. American Heart Journal 2013, 166: 676-683. PMID: 24093847, DOI: 10.1016/j.ahj.2013.07.025.Peer-Reviewed Original ResearchConceptsPrimary percutaneous coronary interventionST-segment resolutionMyocardial blush gradePrimary PCIPercutaneous coronary interventionBlush gradeHORIZONS-AMIMBG 2/3Coronary interventionPrognostic utilityMajor adverse cardiac eventsMyocardial blush grade 2/3ST-elevation myocardial infarctionHORIZONS-AMI trialAdverse cardiac eventsPredictors of deathIndependent prognostic significanceComplementary prognostic informationLong-term outcomesLong-term survivalCardiac eventsReperfusion successIndependent predictorsGrade 2/3Multivariable analysisAlmanac 2013: acute coronary syndromes
Meier P, Lansky AJ, Baumbach A. Almanac 2013: acute coronary syndromes. Heart 2013, 99: 1488. PMID: 23945172, DOI: 10.1136/heartjnl-2013-304649.Peer-Reviewed Original ResearchConceptsST-elevation myocardial infarctionAcute coronary syndromeCoronary syndromeCardiac arrestUnstable coronary artery plaqueRecent therapeutic progressElevation myocardial infarctionNovel antiplatelet agentsCoronary artery plaquesSudden cardiac arrestCommon underlying causeACS mortalityElevation infarctionUnstable anginaAntiplatelet agentsArtery plaquesMyocardial infarctionTherapeutic progressUnderlying causeInfarctionSyndromeArrestAnginaPrasugrelCangrelor
2012
Interventions for ST Elevation Myocardial Infarction in Women
Ng VG, Lansky AJ. Interventions for ST Elevation Myocardial Infarction in Women. Interventional Cardiology Clinics 2012, 1: 453-465. PMID: 28581963, DOI: 10.1016/j.iccl.2012.06.004.Peer-Reviewed Original ResearchST-segment elevation myocardial infarctionElevation myocardial infarctionReperfusion therapyMyocardial infarctionST-elevation myocardial infarctionOutcomes of patientsMinority of patientsOutcomes of womenCoronary revascularization techniquesCause of deathRevascularization techniquesSupportive careTreatment optionsCardiovascular diseaseEquivalent outcomesTherapyWomenMultiple studiesOutcomesInfarctionPatientsMenThrombolyticsDiseaseTrials
2011
Impact of baseline thrombocytopenia on the early and late outcomes after ST-elevation myocardial infarction treated with primary angioplasty: Analysis from the Harmonizing Outcomes with Revascularization and Stents in Acute Myocardial Infarction (HORIZONS-AMI) trial
Hakim DA, Dangas GD, Caixeta A, Nikolsky E, Lansky AJ, Moses JW, Claessen B, Sanidas E, White HD, Ohman EM, Manoukian SV, Fahy M, Mehran R, Stone GW. Impact of baseline thrombocytopenia on the early and late outcomes after ST-elevation myocardial infarction treated with primary angioplasty: Analysis from the Harmonizing Outcomes with Revascularization and Stents in Acute Myocardial Infarction (HORIZONS-AMI) trial. American Heart Journal 2011, 161: 391-396. PMID: 21315224, DOI: 10.1016/j.ahj.2010.11.001.Peer-Reviewed Original ResearchConceptsST-elevation myocardial infarctionPrimary percutaneous coronary interventionBaseline thrombocytopeniaMajor cardiac eventsPercutaneous coronary interventionMyocardial infarctionMajor bleedingPrimary angioplastyCardiac eventsCoronary interventionLate outcomesNet adverse clinical eventsAcute Myocardial Infarction trialHORIZONS-AMI trialMajor cardiovascular eventsMyocardial Infarction trialOutcomes of patientsAcute coronary syndromeAdverse clinical eventsEarly adverse eventsAcute myocardial infarctionHarmonizing OutcomesCardiovascular eventsCoronary syndromeAdverse eventsRationale and design of the INFUSE-AMI study: A 2 × 2 factorial, randomized, multicenter, single-blind evaluation of intracoronary abciximab infusion and aspiration thrombectomy in patients undergoing percutaneous coronary intervention for anterior ST-segment elevation myocardial infarction
Gibson CM, Maehara A, Lansky AJ, Wohrle J, Stuckey T, Dave R, Cox D, Grines C, Dudek D, Steg G, Parise H, Wolff SD, Cristea E, Stone GW. Rationale and design of the INFUSE-AMI study: A 2 × 2 factorial, randomized, multicenter, single-blind evaluation of intracoronary abciximab infusion and aspiration thrombectomy in patients undergoing percutaneous coronary intervention for anterior ST-segment elevation myocardial infarction. American Heart Journal 2011, 161: 478-486.e7. PMID: 21392601, DOI: 10.1016/j.ahj.2010.10.006.Peer-Reviewed Original ResearchMeSH KeywordsAbciximabAngioplasty, Balloon, CoronaryAntibodies, MonoclonalAntithrombinsCoronary OcclusionCoronary ThrombosisEndpoint DeterminationHirudinsHumansImmunoglobulin Fab FragmentsInfusions, Intra-ArterialMagnetic Resonance Imaging, CineMyocardial InfarctionPatient SelectionPeptide FragmentsPlatelet Aggregation InhibitorsRecombinant ProteinsResearch DesignThrombectomyConceptsPrimary percutaneous coronary interventionST-elevation myocardial infarctionPrimary PCIAnterior ST-elevation myocardial infarctionExport aspiration catheterPercutaneous coronary interventionLocal infusionThrombus aspirationInfarct sizeINFUSE-AMIEnd pointCoronary interventionAspiration catheterMyocardial infarctionInfusion catheterAnterior ST-segment elevation myocardial infarctionST-segment elevation myocardial infarctionSingle-blind randomized studyCardiac magnetic resonance imagingMyocardial infarction 0Mid-left anteriorPrimary end pointSafety end pointSecondary end pointsST-segment resolution
2010
Impact of Anemia on Clinical Outcomes of Patients With ST-Segment Elevation Myocardial Infarction in Relation to Gender and Adjunctive Antithrombotic Therapy (from the HORIZONS-AMI Trial)
Tsujita K, Nikolsky E, Lansky AJ, Dangas G, Fahy M, Brodie BR, Dudek D, Möckel M, Ochala A, Mehran R, Stone GW. Impact of Anemia on Clinical Outcomes of Patients With ST-Segment Elevation Myocardial Infarction in Relation to Gender and Adjunctive Antithrombotic Therapy (from the HORIZONS-AMI Trial). The American Journal Of Cardiology 2010, 105: 1385-1394. PMID: 20451683, DOI: 10.1016/j.amjcard.2010.01.001.Peer-Reviewed Original ResearchMeSH KeywordsAgedAnemiaAngioplasty, Balloon, CoronaryCombined Modality TherapyDrug Therapy, CombinationElectrocardiographyFemaleFibrinolytic AgentsFollow-Up StudiesHeparinHirudinsHospital MortalityHumansMaleMiddle AgedMultivariate AnalysisMyocardial InfarctionNeoadjuvant TherapyPeptide FragmentsPlatelet Glycoprotein GPIIb-IIIa ComplexProbabilityProportional Hazards ModelsRecombinant ProteinsRisk AssessmentSex FactorsSurvival AnalysisThrombolytic TherapyTreatment OutcomeConceptsST-elevation myocardial infarctionElevation myocardial infarctionGlycoprotein IIb/IIIa inhibitorsPrimary percutaneous coronary interventionIIb/IIIa inhibitorsBaseline anemiaPercutaneous coronary interventionAdjunctive antithrombotic therapyMajor bleedingMyocardial infarctionAntithrombotic therapyCoronary interventionUnfractionated heparinST-segment elevation myocardial infarctionMultivariate analysisAcute Myocardial Infarction trialImpact of anemiaMyocardial Infarction trialOutcomes of patientsHarmonizing OutcomesCardiac mortalityCause mortalityLate mortalityPrimary PCIClinical outcomes
2007
Impact of Time to Treatment on Myocardial Reperfusion and Infarct Size With Primary Percutaneous Coronary Intervention for Acute Myocardial Infarction (from the EMERALD Trial)
Brodie BR, Webb J, Cox DA, Qureshi M, Kalynych A, Turco M, Schultheiss HP, Dulas D, Rutherford B, Antoniucci D, Stuckey T, Krucoff M, Gibbons R, Lansky A, Na Y, Mehran R, Stone GW, Investigators E. Impact of Time to Treatment on Myocardial Reperfusion and Infarct Size With Primary Percutaneous Coronary Intervention for Acute Myocardial Infarction (from the EMERALD Trial). The American Journal Of Cardiology 2007, 99: 1680-1686. PMID: 17560875, DOI: 10.1016/j.amjcard.2007.01.047.Peer-Reviewed Original ResearchConceptsPrimary percutaneous coronary interventionPrimary PCIPercutaneous coronary interventionSmaller infarct sizeInfarct sizeNonanterior infarctionDistal protectionCoronary interventionMyocardial infarctionST-elevation myocardial infarctionHigh-risk patientsTriage of patientsAcute myocardial infarctionEMERALD trialImpact of timeControl patientsEarly reperfusionMyocardial reperfusionClinical outcomesAnterior infarctionMyocardial blushReperfusionInfarctionMortality ratePatients
2004
1061-100 Predictors of reinfarction after ST elevation myocardial infarction and glycoprotein receptor blockade: Analysis from the CADILLAC trial
Pellizzon G, Marso S, Grines C, Cox D, Garcia E, Tcheng J, Griffin J, Guagliumi G, Stuckey T, Turco M, Carroll J, Lansky A, Mehran R, Rutherford B, Stone G. 1061-100 Predictors of reinfarction after ST elevation myocardial infarction and glycoprotein receptor blockade: Analysis from the CADILLAC trial. Journal Of The American College Of Cardiology 2004, 43: a266. DOI: 10.1016/s0735-1097(04)91131-x.Peer-Reviewed Original Research