2013
Complementary prognostic utility of myocardial blush grade and ST-segment resolution after primary percutaneous coronary intervention: Analysis from the HORIZONS-AMI trial
Brener SJ, Dizon JM, Mehran R, Guerchicoff A, Lansky AJ, Farkouh M, Brodie B, Guagliumi G, Witzenbichler B, Fahy M, Parise H, Stone GW. Complementary prognostic utility of myocardial blush grade and ST-segment resolution after primary percutaneous coronary intervention: Analysis from the HORIZONS-AMI trial. American Heart Journal 2013, 166: 676-683. PMID: 24093847, DOI: 10.1016/j.ahj.2013.07.025.Peer-Reviewed Original ResearchConceptsPrimary percutaneous coronary interventionST-segment resolutionMyocardial blush gradePrimary PCIPercutaneous coronary interventionBlush gradeHORIZONS-AMIMBG 2/3Coronary interventionPrognostic utilityMajor adverse cardiac eventsMyocardial blush grade 2/3ST-elevation myocardial infarctionHORIZONS-AMI trialAdverse cardiac eventsPredictors of deathIndependent prognostic significanceComplementary prognostic informationLong-term outcomesLong-term survivalCardiac eventsReperfusion successIndependent predictorsGrade 2/3Multivariable analysis
2009
Correlations between epicardial flow, microvascular reperfusion, infarct size and clinical outcomes in patients with anterior versus non-anterior myocardial infarction treated with primary or rescue angioplasty: analysis from the EMERALD trial.
Nikolsky E, Stone GW, Lee E, Lansky AJ, Webb J, Cox DA, Brodie BR, Turco MA, Rutherford BD, Kalynych AM, Antoniucci D, Krucoff MW, Gibbons RJ, Fahy M, Mehran R. Correlations between epicardial flow, microvascular reperfusion, infarct size and clinical outcomes in patients with anterior versus non-anterior myocardial infarction treated with primary or rescue angioplasty: analysis from the EMERALD trial. EuroIntervention 2009, 5: 417-24. PMID: 19755327, DOI: 10.4244/eijv5i4a66.Peer-Reviewed Original ResearchMeSH KeywordsAgedAngioplastyAngioplasty, Balloon, CoronaryBlood PressureBradycardiaFemaleHumansMaleMiddle AgedMulticenter Studies as TopicMyocardial InfarctionPostoperative ComplicationsRandomized Controlled Trials as TopicStentsSurvival AnalysisSurvivorsTachycardiaTreatment FailureTreatment OutcomeConceptsAcute myocardial infarctionMicrovascular reperfusionInfarct sizeClinical outcomesMyocardial infarctionEMERALD trialLAD infarctsDistal protectionGrade 3Final TIMI flow grade 3Myocardial blush grade 3Non-anterior myocardial infarctionTIMI flow grade 3ST-segment resolutionEvent-free survivalInfarct-related arteryLarger infarct sizeSevere heart failureRate of reperfusionRescue angioplastyCulprit vesselPrimary PCIReperfusion successEpicardial flowHeart failure
2007
Impact of collateral flow on myocardial reperfusion and infarct size in patients undergoing primary angioplasty for acute myocardial infarction
Sorajja P, Gersh BJ, Mehran R, Lansky AJ, Krucoff MW, Webb J, Cox DA, Brodie BR, Stone GW. Impact of collateral flow on myocardial reperfusion and infarct size in patients undergoing primary angioplasty for acute myocardial infarction. American Heart Journal 2007, 154: 379-384. PMID: 17643592, DOI: 10.1016/j.ahj.2007.04.034.Peer-Reviewed Original ResearchConceptsPrimary percutaneous coronary interventionPrimary PCIBaseline collateral flowInfarct-related arteryAcute myocardial infarctionCollateral flowInfarct sizeClinical outcomesMyocardial reperfusionReperfusion successMyocardial infarctionLess ST segment elevationMajor adverse cardiac eventsAdverse cardiac eventsSubsequent clinical outcomesPercutaneous coronary interventionST-segment elevationST-segment recoveryAcute proceduralEMERALD trialNonanterior infarctionPrimary angioplastyStable anginaArtery occlusionCardiac eventsImpact of multivessel disease on reperfusion success and clinical outcomes in patients undergoing primary percutaneous coronary intervention for acute myocardial infarction
Sorajja P, Gersh BJ, Cox DA, McLaughlin MG, Zimetbaum P, Costantini C, Stuckey T, Tcheng JE, Mehran R, Lansky AJ, Grines CL, Stone GW. Impact of multivessel disease on reperfusion success and clinical outcomes in patients undergoing primary percutaneous coronary intervention for acute myocardial infarction. European Heart Journal 2007, 28: 1709-1716. PMID: 17556348, DOI: 10.1093/eurheartj/ehm184.Peer-Reviewed Original ResearchConceptsPrimary PCIPrimary percutaneous coronary interventionMajor adverse cardiac eventsAcute myocardial infarctionCoronary artery diseaseTriple vessel diseasePercutaneous coronary interventionMultivessel diseaseST-segment recoveryReperfusion successCoronary interventionClinical outcomesMyocardial blushMyocardial infarctionPost-procedural TIMI 3 flowExtent of CADExtensive coronary artery diseaseMultivessel coronary artery diseaseAdverse cardiac eventsTIMI 3 flowInfarct-related arterySingle-vessel diseaseCADILLAC trialPost-PCIInfarct vesselRelation Between Leucocyte Count, Myonecrosis, Myocardial Perfusion, and Outcomes Following Primary Angioplasty
Prasad A, Stone GW, Stuckey TD, Costantini CO, Mehran R, Garcia E, Tcheng JE, Cox DA, Grines CL, Lansky AJ, Gersh BJ. Relation Between Leucocyte Count, Myonecrosis, Myocardial Perfusion, and Outcomes Following Primary Angioplasty. The American Journal Of Cardiology 2007, 99: 1067-1071. PMID: 17437729, DOI: 10.1016/j.amjcard.2006.11.063.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAgedAngioplasty, Balloon, CoronaryCoronary AngiographyCoronary CirculationCreatine KinaseFemaleForecastingHumansLeukocyte CountLeukocytosisMaleMicrocirculationMiddle AgedMyocardial InfarctionMyocardial ReperfusionProspective StudiesRetrospective StudiesSmokingSurvival RateTreatment OutcomeConceptsPrimary percutaneous coronary interventionPrimary PCIBaseline leukocyte countAcute myocardial infarctionHigh leukocyte countLeukocyte countMyocardial perfusionMyocardial blush grade 2/3Myocardial infarction (TIMI) flowMyocardial blush gradePredictors of mortalityPercutaneous coronary interventionNegative prognostic factorPeak creatine phosphokinaseBaseline leukocytosisCADILLAC trialBlush gradePrimary angioplastyCoronary interventionCurrent smokersIndependent predictorsPrognostic factorsReperfusion successClinical outcomesGrade 2/3
2006
Relationship between infarct artery location, epicardial flow, and myocardial perfusion after primary percutaneous revascularization in acute myocardial infarction
Kandzari DE, Tcheng JE, Gersh BJ, Cox DA, Stuckey T, Turco M, Mehran R, Garcia E, Zimetbaum P, McGlaughlin MG, Lansky AJ, Costantini CO, Grines CL, Stone GW, Investigators F. Relationship between infarct artery location, epicardial flow, and myocardial perfusion after primary percutaneous revascularization in acute myocardial infarction. American Heart Journal 2006, 151: 1288-1295. PMID: 16781238, DOI: 10.1016/j.ahj.2005.08.017.Peer-Reviewed Original ResearchConceptsPrimary percutaneous coronary interventionAcute myocardial infarctionPrimary PCIST-segment resolutionMyocardial infarctionReperfusion successVentricular functionClinical outcomesCollateral flowAnterior infarctionMyocardial perfusionArtery locationFinal TIMI 3 flowIschemic target vessel revascularizationMajor adverse cardiac eventsReduced left ventricular functionRight coronary artery distributionPrimary percutaneous revascularizationAdverse cardiac eventsBaseline clinical characteristicsTarget vessel revascularizationTIMI 3 flowMyocardial blush gradePowerful independent predictorPercutaneous coronary intervention
2005
Distal Microcirculatory Protection During Percutaneous Coronary Intervention in Acute ST-Segment Elevation Myocardial Infarction: A Randomized Controlled Trial
Stone GW, Webb J, Cox DA, Brodie BR, Qureshi M, Kalynych A, Turco M, Schultheiss HP, Dulas D, Rutherford BD, Antoniucci D, Krucoff MW, Gibbons RJ, Jones D, Lansky AJ, Mehran R, Investigators F. Distal Microcirculatory Protection During Percutaneous Coronary Intervention in Acute ST-Segment Elevation Myocardial Infarction: A Randomized Controlled Trial. JAMA 2005, 293: 1063-1072. PMID: 15741528, DOI: 10.1001/jama.293.9.1063.Peer-Reviewed Original ResearchConceptsST-segment elevation myocardial infarctionPercutaneous coronary interventionST-segment resolutionAcute ST-segment elevation myocardial infarctionMajor adverse cardiac eventsAdverse cardiac eventsEvent-free survivalElevation myocardial infarctionDistal protectionInfarct sizeMyocardial infarctionCardiac eventsCoronary interventionReperfusion successBalloon occlusionEmergent percutaneous coronary interventionComplete ST-segment resolutionPrimary percutaneous coronary interventionEnd pointDistal balloon occlusionDistal embolic protectionPrimary PCI resultsCoprimary end pointsSecondary end pointsAcute myocardial infarctionCombined prognostic utility of ST-segment recovery and myocardial blush after primary percutaneous coronary intervention in acute myocardial infarction
Sorajja P, Gersh BJ, Costantini C, McLaughlin MG, Zimetbaum P, Cox DA, Garcia E, Tcheng JE, Mehran R, Lansky AJ, Kandzari DE, Grines CL, Stone GW. Combined prognostic utility of ST-segment recovery and myocardial blush after primary percutaneous coronary intervention in acute myocardial infarction. European Heart Journal 2005, 26: 667-674. PMID: 15734768, DOI: 10.1093/eurheartj/ehi167.Peer-Reviewed Original ResearchConceptsPrimary percutaneous coronary interventionAcute myocardial infarctionPrimary PCIPercutaneous coronary interventionST-segment recoveryMyocardial blushCoronary interventionMultivariable analysisPrognostic utilityMyocardial infarctionGreater prognostic utilityStrongest prognostic variableYear clinical outcomesIncremental prognostic informationCADILLAC trialReperfusion therapyReperfusion successClinical outcomesGrade 2/3Independent correlatesMicrocirculatory integrityPrognostic informationUnivariate analysisPoor survivalCumulative rateImpact of diabetes mellitus on myocardial perfusion after primary angioplasty in patients with acute myocardial infarction
Prasad A, Stone GW, Stuckey TD, Costantini CO, Zimetbaum PJ, McLaughlin M, Mehran R, Garcia E, Tcheng JE, Cox DA, Grines CL, Lansky AJ, Gersh BJ. Impact of diabetes mellitus on myocardial perfusion after primary angioplasty in patients with acute myocardial infarction. Journal Of The American College Of Cardiology 2005, 45: 508-514. PMID: 15708696, DOI: 10.1016/j.jacc.2004.10.054.Peer-Reviewed Original ResearchConceptsPrimary PCIPrimary percutaneous coronary interventionST-segment elevation resolutionMyocardial blush gradeAcute myocardial infarctionDiabetes mellitusMyocardial perfusionMyocardial infarctionIndependent predictorsGrade 3Late Angioplasty Complications (CADILLAC) trialTIMI flow grade 3Infarct-related arteryAbnormal myocardial perfusionPercutaneous coronary interventionAbciximab administrationControlled AbciximabPostprocedural ThrombolysisBlush gradePrimary angioplastyComplications TrialCoronary interventionReperfusion successMyocardial reperfusionPoor prognosis