2006
A multicenter, randomized, dose-finding study of gamma intracoronary radiation therapy to inhibit recurrent restenosis after stenting.
Price MJ, Moses JW, Leon MB, Mehran R, Negoita M, Lansky A, Collins M, Giap H, Lin R, Jani S, Steuterman S, Balter S, Dalton J, Lipsztein R, Tripuraneni P, Teirstein PS. A multicenter, randomized, dose-finding study of gamma intracoronary radiation therapy to inhibit recurrent restenosis after stenting. Journal Of Invasive Cardiology 2006, 18: 169-73. PMID: 16732060.Peer-Reviewed Original ResearchConceptsIntracoronary radiation therapyStent restenosisRadiation therapyLesion late lossTarget lesion revascularizationHigh-dose groupDose-finding studySignificant clinical problemBare metal stentsRadiation dose prescriptionHigh radiation doseBinary restenosisLesion revascularizationRecurrent restenosisVessel revascularizationAdverse eventsCoronary interventionRecurrent stenosisComposite endpointRandomized studyDose groupClinical eventsMyocardial infarctionRadiation failureGy group
2003
Beta radiation in lesions > 15 mm: a START subgroup.
Heuser R, Laskey W, Lansky A, Popma J, Bonan R. Beta radiation in lesions > 15 mm: a START subgroup. Journal Of Invasive Cardiology 2003, 15: 641-3. PMID: 14608136.Peer-Reviewed Original ResearchConceptsPlacebo groupLong lesionsStent restenosisSTART trialMajor adverse cardiac eventsAngiographic lesion characteristicsIntracoronary beta radiationAdverse cardiac eventsBinary restenosis rateIncidence of recurrentMean lesion lengthSignificant reductionLesion revascularizationRecurrent restenosisVessel revascularizationAngiographic parametersCardiac eventsClinical restenosisPatient demographicsRestenosis rateCoronary lesionsStent thrombosisLesion characteristicsRadiation groupRadiation therapy
2002
Balloon‐based radiation therapy for treatment of in‐stent restenosis in human coronary arteries: Results from the BRITE I study
Waksman R, Buchbinder M, Reisman M, Lansky AJ, Trauthen B, Whiting J, Li A. Balloon‐based radiation therapy for treatment of in‐stent restenosis in human coronary arteries: Results from the BRITE I study. Catheterization And Cardiovascular Interventions 2002, 57: 286-294. PMID: 12410499, DOI: 10.1002/ccd.10359.Peer-Reviewed Original ResearchMeSH KeywordsAgedArteriesBlood Vessel ProsthesisCatheterizationCoronary AngiographyCoronary RestenosisDose-Response Relationship, RadiationFemaleFollow-Up StudiesHumansIncidenceMaleMiddle AgedPilot ProjectsProspective StudiesRadiotherapy, Computer-AssistedReoperationRisk FactorsStentsTime FactorsTreatment OutcomeConceptsStent restenosisRadiation therapyMajor adverse cardiac eventsAdverse cardiac eventsIntracoronary radiation therapyStudy eligibility criteriaStent restenosis resultsInstances of deathHuman coronary arteriesBinary restenosisRepeat PTCAPrimary endpointCardiac eventsClinical restenosisEmergency surgeryLate complicationsAngioplasty siteRestenosis rateRecurrence rateTotal occlusionConventional therapyCoronary arteryEligibility criteriaLate thrombosisTarget vesselLocalized intracoronary beta radiation therapy to inhibit recurrence of in-stent restenosis
Waksman R, Raizner A, Yeung A, Lansky A, Vandertie L, on behalf of the INHIBIT Investigators. Localized intracoronary beta radiation therapy to inhibit recurrence of in-stent restenosis. Clinical Research In Cardiology 2002, 91: 40-41. DOI: 10.1007/s00392-002-1307-z.Peer-Reviewed Original ResearchTarget lesion revascularizationMajor adverse cardiac eventsPrimary safety endpointTarget vessel revascularizationLesion revascularizationStent restenosisMyocardial infarctionSafety endpointRestenosis rateRadiated groupLong lesionsRadiation therapyBinary angiographic restenosis rateIntracoronary beta-radiation therapyBeta-radiation therapyIntracoronary beta radiationSuccessful coronary interventionAdverse cardiac eventsAngiographic restenosis ratePrimary efficacy endpointIntracoronary radiation therapyRecurrence of restenosisCentering catheterOverall revascularizationEfficacy endpointFive-year clinical and angiographic follow-up after intracoronary iridium-192 radiation therapy
Condado JA, Waksman R, Saucedo JF, Bhargava B, Lansky AJ, Calderas C, Gurdiel O, Gonzalez J, Fadoul M, Parra B, Iturria I, Amezaga B. Five-year clinical and angiographic follow-up after intracoronary iridium-192 radiation therapy. Cardiovascular Revascularization Medicine 2002, 3: 74-81. PMID: 12699836, DOI: 10.1016/s1522-1865(03)00077-5.Peer-Reviewed Original ResearchConceptsQuantitative coronary analysisIntracoronary gamma radiationBalloon angioplastyRadiation therapyAngiographic complicationsStandard balloon angioplastyBinary restenosis rateIntracoronary radiation therapyIncidence of restenosisNew adverse effectsPrevention of restenosisLesion revascularizationUnstable anginaAngioplasty siteRestenosis rateNontarget vesselsTotal occlusionMyocardial infarctionAngiographic effectsClinical trialsAneurysm formationLate lossNeointimal formationLong-term effectsPatientsQuantitative angiographic methods for appropriate end-point analysis, edge-effect evaluation, and prediction of recurrent restenosis after coronary brachytherapy with gamma irradiation
Lansky AJ, Dangas G, Mehran R, Desai KJ, Stone G, Leon M, Mintz G, Waksman R, Wu H, Fahy M. Quantitative angiographic methods for appropriate end-point analysis, edge-effect evaluation, and prediction of recurrent restenosis after coronary brachytherapy with gamma irradiation. Journal Of The American College Of Cardiology 2002, 39: 274-280. PMID: 11788219, DOI: 10.1016/s0735-1097(01)01745-4.Peer-Reviewed Original ResearchConceptsTarget vessel revascularizationRecurrent restenosisDiameter stenosisReceiver operator curveStent restenosisIn-Stent Restenosis TrialIntracoronary radiation therapyPercent diameter stenosisQuantitative coronary angiographyQuantitative angiographic methodsAngiographic locationBlinded therapyRestenosis TrialVessel revascularizationClinical restenosisCoronary angiographyRestenosis rateRestenotic lesionsTreatment failureWashington RadiationBrachytherapy trialsInterventional treatmentVascular brachytherapyEnd-point analysisRadiation therapy
2001
Intravascular Radiation Therapy after Balloon Angioplasty of Narrowed Femoropopliteal Arteries to Prevent Restenosis: Results of the PARIS Feasibility Clinical Trial
Waksman R, Laird J, Jurkovitz C, Lansky A, Gerrits F, Kosinski A, Murrah N, Weintraub W, Investigators F. Intravascular Radiation Therapy after Balloon Angioplasty of Narrowed Femoropopliteal Arteries to Prevent Restenosis: Results of the PARIS Feasibility Clinical Trial. Journal Of Vascular And Interventional Radiology 2001, 12: 915-921. PMID: 11487671, DOI: 10.1016/s1051-0443(07)61569-3.Peer-Reviewed Original ResearchConceptsPercutaneous transluminal angioplastyAnkle-brachial indexRadiation therapySFA lesionsRestenosis rateBalloon angioplastyAngiographic binary restenosis rateMean reference vessel diameterSuccessful percutaneous transluminal angioplastySuperficial femoral artery lesionsClinical restenosis rateFeasibility clinical trialBinary restenosis rateClinical adverse eventsReference vessel diameterFemoral artery lesionsMean lesion lengthRate gamma radiationIntravascular radiation therapyMicroSelectron-HDR afterloaderGamma radiation therapyRutherford scoreAdverse eventsArtery lesionsClinical improvement
1999
Two-year follow-up after intracoronary gamma radiation therapy
Condado J, Waksman R, Calderas C, Saucedo J, Lansky A. Two-year follow-up after intracoronary gamma radiation therapy. Cardiovascular Revascularization Medicine 1999, 1: 30-35. PMID: 11272353, DOI: 10.1016/s1522-1865(98)00014-6.Peer-Reviewed Original ResearchConceptsPercutaneous transluminal coronary angioplastyIntracoronary gamma radiation therapyGamma radiation therapyRadiation therapyBinary restenosisAngiographic binary restenosisMean late lossLate luminal lossTransluminal coronary angioplastyEndovascular revascularization proceduresAngiographic complicationsEarly pseudoaneurysmRestenosis indexAngiographic outcomesLate complicationsCoronary angioplastyRevascularization proceduresLuminal lossLate aneurysmSpontaneous regressionUnfavorable remodelingSerial angiographyLate effectsLate lossLong-term effects
1998
Intracoronary Radiation Post PTCA Prevents Late Arterial Constriction
WAKSMAN R, CONDADO J, SAUCEDO J, LANSKY A, POPMA J, KLEIN J, CROCKER I, WILLIAMS D, KING S. Intracoronary Radiation Post PTCA Prevents Late Arterial Constriction. Journal Of Interventional Cardiology 1998, 11: 535-541. DOI: 10.1111/j.1540-8183.1998.tb00165.x.Peer-Reviewed Original ResearchPost-PTCABalloon angioplastyIntracoronary radiationLate lossLate loss indexLower late lossVascular remodeling effectDe novo lesionsIntracoronary radiation therapyPilot clinical studyMechanism of restenosisNovo lesionsRestenosis rateRadiation trialsPositive remodelingTotal occlusionArterial constrictionClinical studiesVascular remodelingRadiation therapyNeointima formationAnimal modelsPatientsRemodeling effectTrials