2017
Role of Low Endothelial Shear Stress and Plaque Characteristics in the Prediction of Nonculprit Major Adverse Cardiac Events The PROSPECT Study
Stone PH, Maehara A, Coskun AU, Maynard CC, Zaromytidou M, Siasos G, Andreou I, Fotiadis D, Stefanou K, Papafaklis M, Michalis L, Lansky AJ, Mintz GS, Serruys PW, Feldman CL, Stone GW. Role of Low Endothelial Shear Stress and Plaque Characteristics in the Prediction of Nonculprit Major Adverse Cardiac Events The PROSPECT Study. JACC Cardiovascular Imaging 2017, 11: 462-471. PMID: 28917684, DOI: 10.1016/j.jcmg.2017.01.031.Peer-Reviewed Original ResearchMeSH KeywordsCoronary AngiographyCoronary Artery DiseaseCoronary CirculationCoronary VesselsDisease ProgressionEndothelium, VascularEuropeHumansPercutaneous Coronary InterventionPilot ProjectsPlaque, AtheroscleroticPredictive Value of TestsProspective StudiesRisk AssessmentRisk FactorsStress, MechanicalTime FactorsTreatment OutcomeUltrasonography, InterventionalUnited StatesConceptsMajor adverse cardiac eventsLow endothelial shear stressMinimum lumen areaAcute coronary syndromeEndothelial shear stressAdverse cardiac eventsPlaque burdenCoronary lesionsNC-MACECardiac eventsAnatomic riskNC lesionsFuture major adverse cardiac eventsHigh-risk acute coronary syndromesBaseline endothelial shear stressHuman-like animal modelsPrevious natural history studiesPropensity-adjusted Cox regressionSmaller minimum lumen areaPROSPECT studyLocal endothelial shear stressHigh anatomic riskHigh endothelial shear stressNonculprit coronary lesionsHigh-risk patients
2016
TCT-94 Impact of Thin-Cap Fibroatheromas on Unanticipated Ischemic Events in Medically Treated Patients With Diabetes Mellitus: Insights From the PROSPECT Study
Kedhi E, Kennedy M, Maehara A, Lansky A, McAndrew T, Marso S, De Bruyne B, Serruys P, Stone G. TCT-94 Impact of Thin-Cap Fibroatheromas on Unanticipated Ischemic Events in Medically Treated Patients With Diabetes Mellitus: Insights From the PROSPECT Study. Journal Of The American College Of Cardiology 2016, 68: b38-b39. DOI: 10.1016/j.jacc.2016.09.359.Peer-Reviewed Original ResearchImpact of TCFA on Unanticipated Ischemic Events in Medically Treated Diabetes Mellitus Insights From the PROSPECT Study
Kedhi E, Kennedy MW, Maehara A, Lansky AJ, McAndrew TC, Marso SP, De Bruyne B, Serruys PW, Stone GW. Impact of TCFA on Unanticipated Ischemic Events in Medically Treated Diabetes Mellitus Insights From the PROSPECT Study. JACC Cardiovascular Imaging 2016, 10: 451-458. PMID: 27372016, DOI: 10.1016/j.jcmg.2015.12.023.Peer-Reviewed Original ResearchMeSH KeywordsAcute Coronary SyndromeAgedChi-Square DistributionCoronary AngiographyCoronary Artery DiseaseCoronary VesselsDiabetes MellitusDisease ProgressionFemaleFibrosisHumansMaleMiddle AgedPercutaneous Coronary InterventionPlaque, AtheroscleroticPredictive Value of TestsPropensity ScoreRisk FactorsRupture, SpontaneousTime FactorsTreatment OutcomeUltrasonography, InterventionalConceptsMajor adverse cardiac eventsAcute coronary syndromeThin-cap fibroatheromaNonculprit lesionsDiabetes mellitusACS patientsDM patientsSubsequent major adverse cardiac eventsPresence of DMPROSPECT studyAdverse cardiac eventsPropensity-matched groupsRadiofrequency intravascular ultrasoundHigh rateCoronary syndromeCardiac eventsPlaque compositionIntravascular ultrasoundPatientsPropensity scoreBalanced groupsIschemicMellitusFibroatheromaPrognosisLOCALIZATION OF CULPRIT ENDOTHELIAL SHEAR STRESS PATTERNS ALONG THE COURSE OF UNTREATED CORONARY LESIONS RESPONSIBLE FOR FUTURE MACE: THE PROSPECT STUDY
Zaromytidou M, Stone G, Maehara A, Coskun A, Maynard C, Siasos G, Andreou I, Fotiadis D, Stefanou K, Papafaklis M, Michalis L, Lansky A, Mintz G, Serruys P, Feldman C, Stone P. LOCALIZATION OF CULPRIT ENDOTHELIAL SHEAR STRESS PATTERNS ALONG THE COURSE OF UNTREATED CORONARY LESIONS RESPONSIBLE FOR FUTURE MACE: THE PROSPECT STUDY. Journal Of The American College Of Cardiology 2016, 67: 358. DOI: 10.1016/s0735-1097(16)30359-x.Peer-Reviewed Original Research
2013
TCT-659 Total coronary artery calcification as a predictor of advanced atherosclerotic characteristics: The PROSPECT study
Shimizu T, Hamm C, Lansky A, Lerman A, Maehara A, Mintz G, Serruys P, Stone G, Teles R, Templin B, Weisz G, Xu K. TCT-659 Total coronary artery calcification as a predictor of advanced atherosclerotic characteristics: The PROSPECT study. Journal Of The American College Of Cardiology 2013, 62: b201. DOI: 10.1016/j.jacc.2013.08.1408.Peer-Reviewed Original ResearchNon-Fibroatheroma Lesion Phenotype and Long-Term Clinical Outcomes A Substudy Analysis From the PROSPECT Study
Dohi T, Mintz GS, McPherson JA, de Bruyne B, Farhat NZ, Lansky AJ, Mehran R, Weisz G, Xu K, Stone GW, Maehara A. Non-Fibroatheroma Lesion Phenotype and Long-Term Clinical Outcomes A Substudy Analysis From the PROSPECT Study. JACC Cardiovascular Imaging 2013, 6: 908-916. PMID: 23850249, DOI: 10.1016/j.jcmg.2013.04.008.Peer-Reviewed Original ResearchMeSH KeywordsAcute Coronary SyndromeAge FactorsAgedAngina, UnstableChi-Square DistributionCoronary VesselsFemaleFibrosisHospitalizationHumansKaplan-Meier EstimateMaleMiddle AgedMultivariate AnalysisMyocardial InfarctionNecrosisPercutaneous Coronary InterventionPhenotypePlaque, AtheroscleroticPredictive Value of TestsProportional Hazards ModelsProspective StudiesRisk FactorsSeverity of Illness IndexSex FactorsTime FactorsTreatment OutcomeUltrasonography, InterventionalVascular CalcificationConceptsMajor adverse cardiac eventsAcute coronary syndromeNonculprit lesionsClinical outcomesLong-term clinical outcomesVirtual histology intravascular ultrasoundPROSPECT studyCox proportional hazards modelAdverse cardiac eventsIntermediate-term prognosisSuccessful percutaneous interventionOverall plaque burdenLesion phenotypeFA lesionsProportional hazards modelSubstudy analysisCoronary syndromeCulprit lesionCardiac eventsPlaque burdenClinical eventsVH-IVUSPercutaneous interventionClinical impactHazards model
2012
RELATIONSHIP BETWEEN CORONARY ARTERY CALCIFICATION, HIGH-RISK “VULNERABLE PLAQUE” CHARACTERISTICS, AND FUTURE ADVERSE CARDIAC EVENTS: THE PROSPECT STUDY
Shimizu T, Maehara A, Farah T, Teles R, Lerman A, Hamm C, Templin B, Lansky A, Xu K, Weisz G, Serruys P, Mintz G, Stone G. RELATIONSHIP BETWEEN CORONARY ARTERY CALCIFICATION, HIGH-RISK “VULNERABLE PLAQUE” CHARACTERISTICS, AND FUTURE ADVERSE CARDIAC EVENTS: THE PROSPECT STUDY. Journal Of The American College Of Cardiology 2012, 59: e2102. DOI: 10.1016/s0735-1097(12)62103-2.Peer-Reviewed Original ResearchCHARACTERISTICS AND CLINICAL SIGNIFICANCE OF ANGIOGRAPHICALLY MILD LESIONS IN ACUTE CORONARY SYNDROMES: INSIGHTS FROM THE PROSPECT STUDY
Brener S, Mintz G, Cristea E, Weisz G, Maehara A, McPherson J, Marso S, Farhat N, Botker H, Dressler O, Xu K, Templin B, Zhang Z, Lansky A, de Bruyne B, Serruys P, Stone G. CHARACTERISTICS AND CLINICAL SIGNIFICANCE OF ANGIOGRAPHICALLY MILD LESIONS IN ACUTE CORONARY SYNDROMES: INSIGHTS FROM THE PROSPECT STUDY. Journal Of The American College Of Cardiology 2012, 59: e352. DOI: 10.1016/s0735-1097(12)60353-2.Peer-Reviewed Original ResearchLongitudinal Distribution of Plaque Burden and Necrotic Core–Rich Plaques in Nonculprit Lesions of Patients Presenting With Acute Coronary Syndromes
Wykrzykowska JJ, Mintz GS, Garcia-Garcia HM, Maehara A, Fahy M, Xu K, Inguez A, Fajadet J, Lansky A, Templin B, Zhang Z, de Bruyne B, Weisz G, Serruys PW, Stone GW. Longitudinal Distribution of Plaque Burden and Necrotic Core–Rich Plaques in Nonculprit Lesions of Patients Presenting With Acute Coronary Syndromes. JACC Cardiovascular Imaging 2012, 5: s10-s18. PMID: 22421223, DOI: 10.1016/j.jcmg.2012.01.006.Peer-Reviewed Original ResearchMeSH KeywordsAcute Coronary SyndromeAgedAngioplasty, Balloon, CoronaryChi-Square DistributionCoronary Artery DiseaseCoronary StenosisCoronary VesselsEuropeFemaleHumansLipidsMaleMiddle AgedMyocardial InfarctionNecrosisPhenotypePlaque, AtheroscleroticPredictive Value of TestsProspective StudiesRisk AssessmentRisk FactorsSeverity of Illness IndexTime FactorsTreatment OutcomeUltrasonography, InterventionalUnited StatesConceptsLeft main coronary arteryVirtual histology intravascular ultrasoundAcute coronary syndromePlaque burdenDistal coronary treeNonculprit lesionsCoronary syndromeVH-TCFACoronary arteryCoronary treeNecrotic core contentAcute coronary eventsEpicardial coronary arteriesMain coronary arteryAtherosclerotic plaque burdenAcute myocardial infarctionLong segmentCoronary eventsAnterior descendingMyocardial infarctionVulnerable plaquesProportion of NCsArteryLesionsPROSPECT studyGender and the Extent of Coronary Atherosclerosis, Plaque Composition, and Clinical Outcomes in Acute Coronary Syndromes
Lansky AJ, Ng VG, Maehara A, Weisz G, Lerman A, Mintz GS, De Bruyne B, Farhat N, Niess G, Jankovic I, Lazar D, Xu K, Fahy M, Serruys PW, Stone GW. Gender and the Extent of Coronary Atherosclerosis, Plaque Composition, and Clinical Outcomes in Acute Coronary Syndromes. JACC Cardiovascular Imaging 2012, 5: s62-s72. PMID: 22421232, DOI: 10.1016/j.jcmg.2012.02.003.Peer-Reviewed Original ResearchMeSH KeywordsAcute Coronary SyndromeAgedAngina, UnstableAngioplasty, Balloon, CoronaryChi-Square DistributionCoronary AngiographyCoronary Artery DiseaseCoronary StenosisEuropeFemaleFibrosisHeart ArrestHumansKaplan-Meier EstimateLogistic ModelsMaleMiddle AgedMultivariate AnalysisMyocardial InfarctionNecrosisPlaque, AtheroscleroticPredictive Value of TestsProportional Hazards ModelsProspective StudiesRisk AssessmentRisk FactorsSeverity of Illness IndexSex FactorsTime FactorsTreatment OutcomeUltrasonography, InterventionalUnited StatesVascular CalcificationConceptsThin-cap fibroatheromaSimilar plaque burdenAcute coronary syndromePlaque burdenNonculprit lesionsCoronary syndromePlaque rupturePlaque compositionExtensive coronary artery diseaseMajor adverse cardiovascular eventsAcute coronary syndrome eventPROSPECT studyComposition of atherosclerosisNecrotic core volumeThick-cap fibroatheromaUntreated nonculprit lesionsAdverse cardiovascular eventsComorbid risk factorsCoronary artery diseaseMinimal lumen areaSex-based subgroup analysisPathological intimal thickeningCardiovascular eventsMultivariable adjustmentComorbid diseases
2011
DIFFERENCES IN CORONARY PLAQUE COMPOSITION AND MORPHOLOGY IN PATIENTS WITH AND WITHOUT CHRONIC KIDNEY DISEASE PRESENTING WITH ACUTE CORONARY SYNDROMES: INSIGHTS FROM THE PROSPECT STUDY
Baber U, Mehran R, Weisz G, Dangas G, Moreno P, Maehara A, Cristea E, Fahy M, Xu K, Lansky A, Marso S, de Bruyne B, Serruys P, Stone G. DIFFERENCES IN CORONARY PLAQUE COMPOSITION AND MORPHOLOGY IN PATIENTS WITH AND WITHOUT CHRONIC KIDNEY DISEASE PRESENTING WITH ACUTE CORONARY SYNDROMES: INSIGHTS FROM THE PROSPECT STUDY. Journal Of The American College Of Cardiology 2011, 57: e1442. DOI: 10.1016/s0735-1097(11)61442-3.Peer-Reviewed Original Research