2013
Impact of infarct-related artery patency before primary PCI on outcome in patients with ST-segment elevation myocardial infarction: the HORIZONS-AMI trial.
Rakowski T, Dudek D, Dziewierz A, Yu J, Witzenbichler B, Guagliumi G, Kornowski R, Hartmann F, Lansky AJ, Brener SJ, Mehran R, Stone GW. Impact of infarct-related artery patency before primary PCI on outcome in patients with ST-segment elevation myocardial infarction: the HORIZONS-AMI trial. EuroIntervention 2013, 8: 1307-14. PMID: 23538158, DOI: 10.4244/eijv8i11a199.Peer-Reviewed Original ResearchMeSH KeywordsAgedChi-Square DistributionCoronary AngiographyCoronary CirculationCoronary StenosisCoronary VesselsElectrocardiographyFemaleHumansKaplan-Meier EstimateMaleMiddle AgedMultivariate AnalysisMyocardial InfarctionPercutaneous Coronary InterventionPredictive Value of TestsProportional Hazards ModelsProspective StudiesRisk AssessmentRisk FactorsThrombosisTime FactorsTreatment OutcomeVascular PatencyConceptsEarly IRA patencyPrimary percutaneous coronary interventionPercutaneous coronary interventionHORIZONS-AMI trialOne-year mortalityIRA patencyIndependent predictorsST-segment elevation myocardial infarctionMyocardial blush grade 2Infarct-related artery patencyBaseline coronary angiographyBetter TIMI flowMyocardial Infarction 2Probable stent thrombosisTIMI 3 flowOne-year outcomesOutcomes of patientsElevation myocardial infarctionGood angiographic resultBaseline angiographyTIMI 0TIMI flowArtery patencyCoronary interventionCoronary angiography
2006
Prognostic Implications of Creatine Kinase Elevation After Primary Percutaneous Coronary Intervention for Acute Myocardial Infarction
Halkin A, Stone GW, Grines CL, Cox DA, Rutherford BD, Esente P, Meils CM, Albertsson P, Farah A, Tcheng JE, Lansky AJ, Mehran R. Prognostic Implications of Creatine Kinase Elevation After Primary Percutaneous Coronary Intervention for Acute Myocardial Infarction. Journal Of The American College Of Cardiology 2006, 47: 951-961. PMID: 16516077, DOI: 10.1016/j.jacc.2005.12.003.Peer-Reviewed Original ResearchConceptsPrimary percutaneous coronary interventionAcute myocardial infarctionPrimary PCIPercutaneous coronary interventionCreatine kinase elevationCoronary interventionPrognostic implicationsMyocardial infarctionCK levelsLate Angioplasty Complications (CADILLAC) trialLeft ventricular ejection fractionOne-year survivorsPost-PCI ThrombolysisMyocardial infarction (TIMI) flowOne-year mortalityAntegrade blood flowVentricular ejection fractionPeak creatine kinaseCK monitoringControlled AbciximabComplications TrialMost patientsEjection fractionIndependent predictorsMortality independent
2005
Prediction of Mortality After Primary Percutaneous Coronary Intervention for Acute Myocardial Infarction The CADILLAC Risk Score
Halkin A, Singh M, Nikolsky E, Grines CL, Tcheng JE, Garcia E, Cox DA, Turco M, Stuckey TD, Na Y, Lansky AJ, Gersh BJ, O’Neill W, Mehran R, Stone GW. Prediction of Mortality After Primary Percutaneous Coronary Intervention for Acute Myocardial Infarction The CADILLAC Risk Score. Journal Of The American College Of Cardiology 2005, 45: 1397-1405. PMID: 15862409, DOI: 10.1016/j.jacc.2005.01.041.Peer-Reviewed Original ResearchConceptsPrimary percutaneous coronary interventionPrimary PCIAcute myocardial infarctionBaseline left ventricular functionOne-year mortalityPercutaneous coronary interventionLeft ventricular functionRisk scoreCoronary interventionVentricular functionMyocardial infarctionCADILLAC risk scoreExcellent prognostic accuracyPrevious risk scoresStrata of riskAccurate risk stratificationLong-term mortalitySimple risk scoreRespective odds ratiosPrediction of mortalityRisk score modelTime of interventionInitial multivariate modelInteger scoring systemAngiographic variables
2004
Outcome in Elderly Patients Undergoing Primary Coronary Intervention for Acute Myocardial Infarction
Guagliumi G, Stone GW, Cox DA, Stuckey T, Tcheng JE, Turco M, Musumeci G, Griffin JJ, Lansky AJ, Mehran R, Grines CL, Garcia E. Outcome in Elderly Patients Undergoing Primary Coronary Intervention for Acute Myocardial Infarction. Circulation 2004, 110: 1598-1604. PMID: 15353506, DOI: 10.1161/01.cir.0000142862.98817.1f.Peer-Reviewed Original ResearchMeSH KeywordsAbciximabAdrenergic beta-AntagonistsAdultAge FactorsAgedAged, 80 and overAngioplasty, Balloon, CoronaryAntibodies, MonoclonalAspirinCohort StudiesCombined Modality TherapyCoronary AngiographyCoronary RestenosisFemaleHemorrhageHumansImmunoglobulin Fab FragmentsLife TablesMaleMiddle AgedMyocardial InfarctionPlatelet Aggregation InhibitorsProportional Hazards ModelsPyridinesStentsStrokeTreatment OutcomeConceptsAcute myocardial infarctionGlycoprotein IIb/IIIa inhibitorsPrimary percutaneous coronary interventionIIb/IIIa inhibitorsElderly patientsPercutaneous coronary interventionMajor bleedingYears of ageCoronary interventionClinical outcomesStent implantationMyocardial infarctionPlatelet glycoprotein IIb/IIIa inhibitorsDecile of ageMechanical reperfusion strategiesOne-year mortalityPrimary coronary interventionRate of strokeCoronary stent implantationImpact of ageRate of mortalityAbciximab administrationCADILLAC trialReperfusion modalityTarget revascularizationImpact of anemia in patients with acute myocardial infarction undergoing primary percutaneous coronary intervention Analysis from the controlled abciximab and device investigation to lower late angioplasty complications (cadillac) trial
Nikolsky E, Aymong ED, Halkin A, Grines CL, Cox DA, Garcia E, Mehran R, Tcheng JE, Griffin JJ, Guagliumi G, Stuckey T, Turco M, Cohen DA, Negoita M, Lansky AJ, Stone GW. Impact of anemia in patients with acute myocardial infarction undergoing primary percutaneous coronary intervention Analysis from the controlled abciximab and device investigation to lower late angioplasty complications (cadillac) trial. Journal Of The American College Of Cardiology 2004, 44: 547-553. PMID: 15358018, DOI: 10.1016/j.jacc.2004.03.080.Peer-Reviewed Original ResearchMeSH KeywordsAbciximabAgedAnemiaAngioplasty, Balloon, CoronaryAntibodies, MonoclonalBlood Component TransfusionFemaleHematocritHemorrhageHospital MortalityHumansImmunoglobulin Fab FragmentsIncidenceMaleMiddle AgedMultivariate AnalysisMyocardial InfarctionPlatelet Aggregation InhibitorsPredictive Value of TestsPrognosisRandomized Controlled Trials as TopicStentsStrokeSurvival AnalysisTreatment OutcomeConceptsPrimary percutaneous coronary interventionAcute myocardial infarctionPrimary PCILate Angioplasty Complications (CADILLAC) trialImpact of anemiaComplications TrialMyocardial infarctionWorld Health Organization criteriaPrimary PCI outcomesBlood product transfusionOne-year mortalityBaseline laboratory valuesPercutaneous coronary interventionPresence of anemiaBaseline anemiaControlled AbciximabHospital mortalityProduct transfusionHemorrhagic complicationsIndex hospitalizationCoronary interventionIndependent predictorsPCI outcomesPrognostic importanceAdverse outcomesShort- and long-term results after multivessel stenting in diabetic patients
Moses J, Mehran R, Dangas G, Kobayashi Y, Lansky A, Mintz G, Aymong E, Fahy M, Stone GW, Leon MB. Short- and long-term results after multivessel stenting in diabetic patients. Journal Of The American College Of Cardiology 2004, 43: 1348-1354. PMID: 15093865, DOI: 10.1016/j.jacc.2003.04.004.Peer-Reviewed Original ResearchConceptsCoronary artery bypass graft surgeryNon-diabetic patientsHospital coronary artery bypass graft surgeryOne-year survivalDiabetic patientsMultivessel stentingOral agentsRevascularization ratesClinical outcomesProcedural successMyocardial infarctionTarget lesion revascularization rateArtery bypass graft surgeryHigh technical success rateDiabetes mellitus statusExcellent procedural successHospital cardiac deathSubsequent revascularization ratesBypass graft surgeryLesion revascularization rateNative coronary lesionsOne-year mortalityTechnical success rateConventional balloon angioplastyAcceptable clinical outcomes
2003
Impact of gender on the incidence and outcome of contrast-induced nephropathy after percutaneous coronary intervention.
Iakovou I, Dangas G, Mehran R, Lansky AJ, Ashby DT, Fahy M, Mintz GS, Kent KM, Pichard AD, Satler LF, Stone GW, Leon MB. Impact of gender on the incidence and outcome of contrast-induced nephropathy after percutaneous coronary intervention. Journal Of Invasive Cardiology 2003, 15: 18-22. PMID: 12499523.Peer-Reviewed Original ResearchConceptsContrast-induced nephropathyChronic renal failureOne-year mortalityIndependent predictorsPercutaneous interventionDiabetes mellitusClinical outcomesFemale genderMultivariate analysisOne-year clinical eventsNYHA IV classSevere heart failurePercutaneous coronary interventionImpact of genderCoronary interventionRenal failureHeart failureMale patientsCIN developmentClinical eventsPatientsMortalityMellitusNephropathySignificant gender differences
2002
Postprocedure creatine kinase-MB elevation and baseline left ventricular dysfunction predict one-year mortality after percutaneous coronary intervention
Dangas G, Mehran R, Feldman D, Stoyioglou A, Pichard AD, Kent KM, Satler LF, Fahy M, Lansky AJ, Stone GW, Leon MB. Postprocedure creatine kinase-MB elevation and baseline left ventricular dysfunction predict one-year mortality after percutaneous coronary intervention. The American Journal Of Cardiology 2002, 89: 586-589. PMID: 11867045, DOI: 10.1016/s0002-9149(01)02299-8.Peer-Reviewed Original Research
2000
The prognostic implications of further renal function deterioration within 48 h of interventional coronary procedures in patients with pre-existent chronic renal insufficiency
Gruberg L, Mintz G, Mehran R, Dangas G, Lansky A, Kent K, Pichard A, Satler L, Leon M. The prognostic implications of further renal function deterioration within 48 h of interventional coronary procedures in patients with pre-existent chronic renal insufficiency. Journal Of The American College Of Cardiology 2000, 36: 1542-1548. PMID: 11079656, DOI: 10.1016/s0735-1097(00)00917-7.Peer-Reviewed Original ResearchConceptsRenal function deteriorationFurther renal function deteriorationOne-year mortalityFunction deteriorationCoronary interventionCreatinine increaseHospital mortalityRenal insufficiencyRenal functionSerum creatinineIndependent predictorsPre-existing renal insufficiencyHospital clinical eventsBaseline serum creatinineChronic renal insufficiencyLong-term mortalityTertiary referral centerPercutaneous coronary interventionVentricular ejection fractionInterventional coronary proceduresChronic dialysisCreatinine elevationAcute deteriorationReferral centerConsecutive patients