2015
Safety and efficacy of a novel abluminal groove‐filled biodegradable polymer sirolimus‐eluting stent for the treatment of de novo coronary lesions: Two‐year results from a prospective patient‐level pooled analysis of TARGET trials
Gao Z, Zhang R, Xu B, Yang Y, Ma C, Li H, Chen S, Han Y, Yuan Z, Lansky AJ, Guan C, Leon MB, Gao R, Investigators F. Safety and efficacy of a novel abluminal groove‐filled biodegradable polymer sirolimus‐eluting stent for the treatment of de novo coronary lesions: Two‐year results from a prospective patient‐level pooled analysis of TARGET trials. Catheterization And Cardiovascular Interventions 2015, 85: 734-743. PMID: 25678281, DOI: 10.1002/ccd.25861.Peer-Reviewed Original ResearchMeSH KeywordsAbsorbable ImplantsAgedCardiovascular AgentsChinaCoronary Artery DiseaseDrug-Eluting StentsFemaleHumansKaplan-Meier EstimateMaleMiddle AgedMyocardial InfarctionPercutaneous Coronary InterventionPolymersProspective StudiesProsthesis DesignRandomized Controlled Trials as TopicRegistriesRisk FactorsSirolimusTime FactorsTreatment OutcomeConceptsTarget lesion failureFIREHAWK stentStent thrombosisCoronary lesionsMyocardial infarctionNovel abluminal groove-filled biodegradable polymer sirolimus-eluting stentDe novo native coronary lesionsBiodegradable polymer sirolimus-eluting stentsDe novo coronary lesionsPatient-level pooled analysisTarget vessel myocardial infarctionNew drug-eluting stentsNative coronary lesionsNovo coronary lesionsProbable stent thrombosisTarget lesion revascularizationVessel myocardial infarctionSirolimus-eluting stentsPatient-level analysisPatient-level dataLong-term safetyDrug-eluting stentsTwo-year resultsObjective performance criteriaLesion revascularization
2013
A randomised comparison of a novel abluminal groove-filled biodegradable polymer sirolimus-eluting stent with a durable polymer everolimus-eluting stent: clinical and angiographic follow-up of the TARGET I trial.
Gao RL, Xu B, Lansky AJ, Yang YJ, Ma CS, Han YL, Chen SL, Li H, Zhang RY, Fu GS, Yuan ZY, Jiang H, Huo Y, Li W, Zhang YJ, Leon MB. A randomised comparison of a novel abluminal groove-filled biodegradable polymer sirolimus-eluting stent with a durable polymer everolimus-eluting stent: clinical and angiographic follow-up of the TARGET I trial. EuroIntervention 2013, 9: 75-83. PMID: 23685298, DOI: 10.4244/eijv9i1a12.Peer-Reviewed Original ResearchMeSH KeywordsAbsorbable ImplantsAgedAnalysis of VarianceAntineoplastic AgentsChi-Square DistributionChinaCoronary AngiographyCoronary Artery DiseaseCoronary RestenosisCoronary StenosisCoronary ThrombosisDrug-Eluting StentsEverolimusFemaleHumansLeast-Squares AnalysisMaleMiddle AgedMyocardial InfarctionPercutaneous Coronary InterventionPolymersPredictive Value of TestsProspective StudiesProsthesis DesignSirolimusTime FactorsTreatment OutcomeConceptsIschaemia-driven target lesion revascularisationStent late lumen lossTarget vessel myocardial infarctionLate lumen lossTarget lesion failureSingle de novo coronary lesionsDe novo coronary lesionsNovo coronary lesionsCoronary lesionsPrimary endpointCardiac deathI trialNovel abluminal groove-filled biodegradable polymer sirolimus-eluting stentSingle de novo native coronary lesionsDe novo native coronary lesionsBiodegradable polymer sirolimus-eluting stentsNine monthsNative coronary lesionsProbable stent thrombosisTarget lesion revascularisationVessel myocardial infarctionSirolimus-eluting stentsNon-inferiority trialLesion revascularisationEES groupPlaque shift and distal embolism in patients with acute myocardial infarction
Wu X, Maehara A, He Y, Xu K, Oviedo C, Witzenbichler B, Lansky AJ, Dressler O, Parise H, Stone GW, Mintz GS. Plaque shift and distal embolism in patients with acute myocardial infarction. Catheterization And Cardiovascular Interventions 2013, 82: 203-209. PMID: 22936619, DOI: 10.1002/ccd.24644.Peer-Reviewed Original ResearchMeSH KeywordsAgedBiomarkersChi-Square DistributionCoronary AngiographyCoronary Artery DiseaseCoronary ThrombosisCoronary VesselsCreatine Kinase, MB FormEmbolismFemaleHumansLinear ModelsMaleMiddle AgedMyocardial InfarctionNo-Reflow PhenomenonPercutaneous Coronary InterventionPlaque, AtheroscleroticPredictive Value of TestsProsthesis DesignRandomized Controlled Trials as TopicRetrospective StudiesStentsTreatment OutcomeUltrasonography, InterventionalConceptsThrombus groupCK-MBAngiographic thrombusPlaque shiftReference segmentsAxial plaque redistributionDistal plaque embolizationDistal reference segmentsHORIZONS-AMI trialNative coronary lesionsM volumeAcute myocardial infarctionVolumetric intravascular ultrasoundBare metal stentsOverall plaque volumePeriprocedural elevationPlaque redistributionDistal embolismCoronary lesionsPlaque embolizationMyocardial infarctionStent implantationPlaque volumeInfarction lesionsIntravascular ultrasound
2010
Incidence, Mechanisms, Predictors, and Clinical Impact of Acute and Late Stent Malapposition After Primary Intervention in Patients With Acute Myocardial Infarction
Guo N, Maehara A, Mintz GS, He Y, Xu K, Wu X, Lansky AJ, Witzenbichler B, Guagliumi G, Brodie B, Kellett MA, Dressler O, Parise H, Mehran R, Stone GW. Incidence, Mechanisms, Predictors, and Clinical Impact of Acute and Late Stent Malapposition After Primary Intervention in Patients With Acute Myocardial Infarction. Circulation 2010, 122: 1077-1084. PMID: 20805433, DOI: 10.1161/circulationaha.109.906040.Peer-Reviewed Original ResearchConceptsAcute stent malappositionPaclitaxel-eluting stentsBare metal stentsLate stent malappositionPES-treated lesionsStent malappositionPositive remodelingMyocardial infarctionST-segment elevation myocardial infarction (STEMI) patientsST-segment elevation myocardial infarctionEquivalent bare metal stentsAcute Myocardial Infarction trialElevation myocardial infarction patientsASM areaExternal elastic membrane areaIntravascular ultrasound substudyPeri-stent plaquePrimary stent implantationMyocardial Infarction trialNative coronary lesionsElevation myocardial infarctionAcute myocardial infarctionMyocardial infarction patientsSubset of lesionsExternal elastic membrane
2007
Randomized, double‐blind, multicenter study of the polymer‐based 17‐β estradiol‐eluting stent for treatment of native coronary artery lesions: Six‐month results of the ETHOS I trial
Abizaid A, Chaves Á, Leon MB, Hauptmann K, Mehran R, Lansky AJ, Baumbach W, Shankar H, Muller R, Feres F, Sousa AG, Sousa JE, Grube E. Randomized, double‐blind, multicenter study of the polymer‐based 17‐β estradiol‐eluting stent for treatment of native coronary artery lesions: Six‐month results of the ETHOS I trial. Catheterization And Cardiovascular Interventions 2007, 70: 654-660. PMID: 17932898, DOI: 10.1002/ccd.21210.Peer-Reviewed Original ResearchConceptsStent volume obstructionIntravascular ultrasoundVolume obstructionI trialCoronary lesionsSingle de novo native coronary lesionsDe novo native coronary lesionsMean reference vessel diameterMajor adverse cardiac eventsNative coronary artery lesionsBinary angiographic restenosisAdverse cardiac eventsNative coronary lesionsPrimary end pointCoronary artery lesionsReference vessel diameterSix-month resultsStent late lossTreatment of patientsBare metal stentsMean lesion lengthLesion revascularizationAngiographic restenosisPrimary endpointSecondary endpointsCobalt chromium stent with antiproliferative for restenosis trial in India (COSTAR I).
Kaul U, Gupta RK, Mathur A, Dani S, Sapra R, Nayak PR, Lansky A, Cristea E, Carlier S, Gambone L, Litvack F. Cobalt chromium stent with antiproliferative for restenosis trial in India (COSTAR I). Indian Heart Journal 2007, 59: 165-72. PMID: 19122251.Peer-Reviewed Original ResearchConceptsStent late lossGroup 2Group 1Late lossI trialCoronary lesionsGroup 3De novo coronary lesionsSegment late lossBinary restenosis rateNative coronary lesionsNovo coronary lesionsMulti-center registryCoronary stent systemRelease formulationExtended-release formulationSmall-caliber vesselsCobalt-chromium stentNovo lesionsPrimary endpointRestenosis TrialRestenosis rateClinical outcomesFeasibility trialClinical results
2005
Randomized comparison of carbon ion–implanted stent versus bare metal stent in coronary artery disease: The Asian Pacific Multicenter Arthos Stent Study (PASS) trial
Kim YH, Lee CW, Hong MK, Park SW, Tahk SJ, Yang JY, Saito S, Santoso T, Quan L, Ge J, Weissman NJ, Lansky AJ, Mintz GS, Park SJ. Randomized comparison of carbon ion–implanted stent versus bare metal stent in coronary artery disease: The Asian Pacific Multicenter Arthos Stent Study (PASS) trial. American Heart Journal 2005, 149: 336-341. PMID: 15846274, DOI: 10.1016/j.ahj.2004.02.018.Peer-Reviewed Original ResearchConceptsMajor adverse cardiac eventsAngiographic restenosis rateLong-term outcomesLate lossRestenosis rateGroup 2Group 1Adverse cardiac eventsNative coronary lesionsNonfatal myocardial infarctionCoronary artery diseaseMulticenter clinical studyLesion revascularizationPrimary endpointSecondary endpointsBaseline characteristicsCardiac eventsArtery diseaseCoronary lesionsHospital eventsRandomized comparisonBare metalMyocardial infarctionClinical studiesInflammatory reaction
2004
Relation of final lumen dimensions in saphenous vein grafts after stent implantation to outcome
Iakovou I, Dangas G, Mintz GS, Mehran R, Kobayashi Y, Aymong E, Hirose M, Ashby DT, Lansky AJ, Stone GW, Leon MB, Moses JW. Relation of final lumen dimensions in saphenous vein grafts after stent implantation to outcome. The American Journal Of Cardiology 2004, 93: 963-968. PMID: 15081436, DOI: 10.1016/j.amjcard.2003.12.049.Peer-Reviewed Original ResearchConceptsSaphenous vein graftsAggressive stent expansionSVG lesionsStent expansionVein graftsMyocardial infarctionStent implantationHospital non-Q-wave myocardial infarctionLumen dimensionsGroup IINon-Q-wave myocardial infarctionIntravascular ultrasound-guided stentingTarget vessel revascularization rateVessel revascularization rateBaseline patient characteristicsMyocardial infarction rateNative coronary lesionsStent cross-sectional areaTarget vessel revascularizationPercutaneous coronary interventionNative coronary arteriesCross-sectional areaLower restenosis rateRevascularization ratesVessel revascularizationShort- and long-term results after multivessel stenting in diabetic patients
Moses J, Mehran R, Dangas G, Kobayashi Y, Lansky A, Mintz G, Aymong E, Fahy M, Stone GW, Leon MB. Short- and long-term results after multivessel stenting in diabetic patients. Journal Of The American College Of Cardiology 2004, 43: 1348-1354. PMID: 15093865, DOI: 10.1016/j.jacc.2003.04.004.Peer-Reviewed Original ResearchConceptsCoronary artery bypass graft surgeryNon-diabetic patientsHospital coronary artery bypass graft surgeryOne-year survivalDiabetic patientsMultivessel stentingOral agentsRevascularization ratesClinical outcomesProcedural successMyocardial infarctionTarget lesion revascularization rateArtery bypass graft surgeryHigh technical success rateDiabetes mellitus statusExcellent procedural successHospital cardiac deathSubsequent revascularization ratesBypass graft surgeryLesion revascularization rateNative coronary lesionsOne-year mortalityTechnical success rateConventional balloon angioplastyAcceptable clinical outcomes1155-78 Implications and prevention of large periprocedural myocardial infarction after percutaneous intervention of diseased saphenous vein grafts and thrombotic native coronary lesions
Lasic Z, Mehran R, Nikolsky E, Negoita M, Costa R, Cox D, Babb J, Nukta D, Bilodeau L, Cannon L, Stuckey T, Hermiller J, Lansky A, Leon M, Stone G. 1155-78 Implications and prevention of large periprocedural myocardial infarction after percutaneous intervention of diseased saphenous vein grafts and thrombotic native coronary lesions. Journal Of The American College Of Cardiology 2004, 43: a88. DOI: 10.1016/s0735-1097(04)90367-1.Peer-Reviewed Original ResearchDiseased saphenous vein graftsNative coronary lesionsPeriprocedural myocardial infarctionSaphenous vein grafts
2003
Correlation of coronary arterial remodeling determined by intravascular ultrasound with angiographic diameter reduction of 20% to 60%
Hirose M, Kobayashi Y, Mintz GS, Moussa I, Mehran R, Lansky AJ, Dangas G, Kreps EM, Collins MB, Stone GW, Colombo A, Leon MB, Moses JW. Correlation of coronary arterial remodeling determined by intravascular ultrasound with angiographic diameter reduction of 20% to 60%. The American Journal Of Cardiology 2003, 92: 141-145. PMID: 12860214, DOI: 10.1016/s0002-9149(03)00528-9.Peer-Reviewed Original ResearchConceptsEEM cross-sectional areaNegative remodelingIntermediate remodelingPositive remodelingIntermediate stenosisCoronary lesionsCross-sectional areaDistal referenceIntravascular ultrasoundExternal elastic membrane cross-sectional areaLumen cross-sectional areaPreintervention intravascular ultrasoundStenotic coronary lesionsNative coronary lesionsCoronary arterial remodelingCoronary stenosisArterial remodelingProximal referenceLess plaqueArea stenosisStenosisLesionsLesion formationHard plaquesRemodeling occurs
2000
The PARAGON stent study: a randomized trial of a new martensitic nitinol stent versus the Palmaz-Schatz stent for treatment of complex native coronary arterial lesions
Holmes D, Lansky A, Kuntz R, Bell M, Buchbinder M, Fortuna R, O’Shaughnessy C, Popma J, Investigators F. The PARAGON stent study: a randomized trial of a new martensitic nitinol stent versus the Palmaz-Schatz stent for treatment of complex native coronary arterial lesions. The American Journal Of Cardiology 2000, 86: 1073-1079. PMID: 11074202, DOI: 10.1016/s0002-9149(00)01162-0.Peer-Reviewed Original ResearchConceptsStent minimal lumen diameterTarget vessel failureMinimal lumen diameterAngiographic restenosisPalmaz-SchatzLumen diameterPS stentEnd pointSignificant differencesAverage stent lengthBinary angiographic restenosisInfrequent adverse eventsPrimary end pointSecondary end pointsSmaller reference vesselsCoronary arterial lesionsNative coronary lesionsPrior bypass surgeryLong-term outcomesPalmaz-Schatz stentsPrior restenosisLesion revascularizationPercutaneous revascularizationBypass surgeryClinical restenosisMechanism of Lumen Enlargement During Intracoronary Stent Implantation
Ahmed J, Mintz G, Weissman N, Lansky A, Pichard A, Satler L, Kent K. Mechanism of Lumen Enlargement During Intracoronary Stent Implantation. Circulation 2000, 102: 7-10. PMID: 10880407, DOI: 10.1161/01.cir.102.1.7.Peer-Reviewed Original ResearchConceptsLumen enlargementReference segmentsExternal elastic membrane areaDistal reference segmentsNative coronary lesionsIntracoronary stent implantationIntravascular ultrasound analysisMean lumen areaExternal elastic membraneCoronary lesionsPlaque burdenPlaque embolizationStent implantationMultilink stentsProximal referenceDistal referenceIntravascular ultrasoundLesionsUltrasound analysisLumen areaPlaquesVolumetric analysisVessel expansionInterventionMedia areaAtherosclerotic Plaque Burden and CK-MB Enzyme Elevation After Coronary Interventions
Mehran R, Dangas G, Mintz G, Lansky A, Pichard A, Satler L, Kent K, Stone G, Leon M. Atherosclerotic Plaque Burden and CK-MB Enzyme Elevation After Coronary Interventions. Circulation 2000, 101: 604-610. PMID: 10673251, DOI: 10.1161/01.cir.101.6.604.Peer-Reviewed Original ResearchConceptsCK-MB elevationAtherosclerotic plaque burdenPreintervention intravascular ultrasoundPlaque burdenTimes upper limitIntravascular ultrasoundCoronary interventionSerum creatine kinase MB fractionPlatelet glycoprotein IIb/IIIa inhibitorsGlycoprotein IIb/IIIa inhibitorsReference segmentsFinal minimal lumen diameterLesion site plaque burdenIIb/IIIa inhibitorsCreatine kinase MB fractionAngiographic lesion morphologyDe novo lesionsNative coronary lesionsPercutaneous coronary interventionMinimal lumen diameterDiffuse atherosclerotic diseaseCatheter-based interventionsCross-sectional narrowingAtheroablative techniquesLate mortality
1997
Comparison of Men Versus Women in Cross-Sectional Area Luminal Narrowing, Quantity of Plaque, Presence of Calcium in Plaque, and Lumen Location in Coronary Arteries by Intravascular Ultrasound in Patients with Stable Angina Pectoris
Kornowski R, Lansky A, Mintz G, Kent K, Pichard A, Satler L, Bucher T, Popma J, Leon M. Comparison of Men Versus Women in Cross-Sectional Area Luminal Narrowing, Quantity of Plaque, Presence of Calcium in Plaque, and Lumen Location in Coronary Arteries by Intravascular Ultrasound in Patients with Stable Angina Pectoris. The American Journal Of Cardiology 1997, 79: 1601-1605. PMID: 9202348, DOI: 10.1016/s0002-9149(97)00206-3.Peer-Reviewed Original ResearchConceptsExternal elastic membraneIntravascular ultrasoundCoronary atherosclerosisPlaque burdenCross-sectional area luminal narrowingPreinterventional intravascular ultrasoundNative coronary lesionsStable angina pectorisMen Versus WomenProximal reference siteBody surface areaComorbid clinical conditionsQuantity of plaqueChronic anginaCoronary interventionAngina pectorisCoronary lesionsLuminal narrowingCoronary arteryIVUS analysisPlaque eccentricityTarget lesionsIVUS measuresClinical conditionsM area