2022
Left Ventricular Remodeling After Anterior-STEMI PCI: Imaging Observations in the Door-to-Unload (DTU) Pilot Trial.
O'Neill WW, Wang DD, Polak S, Moses JW, Josephy N, Koenig G, Kim RJ, Lansky A, Bellumkonda L, Douglas PS, Kapur NK. Left Ventricular Remodeling After Anterior-STEMI PCI: Imaging Observations in the Door-to-Unload (DTU) Pilot Trial. Journal Of Invasive Cardiology 2022, 34: e611-e619. PMID: 35830361, DOI: 10.25270/jic/21.00401.Peer-Reviewed Original ResearchConceptsCardiac magnetic resonanceLV ejection fractionInfarct sizeLeft ventricularLV unloadingEjection fractionPilot trialGroup 2Group 1ST-segment elevation myocardial infarction (STEMI) patientsImproved LV ejection fractionElevation myocardial infarction patientsLV end-diastolic volumeMajor cardiovascular outcomesPercutaneous coronary interventionMyocardial infarction patientsEnd-diastolic volumeEnd-systolic volumeAnterior STEMIEchocardiographic LVEFCardiogenic shockCardiovascular outcomesEchocardiographic parametersImmediate reperfusionCoronary interventionDepression and Perceived Stress After Spontaneous Coronary Artery Dissection and Comparison With Other Acute Myocardial Infarction (the VIRGO Experience)
Murugiah K, Chen L, Dreyer RP, Bouras G, Safdar B, Lu Y, Spatz ES, Gupta A, Khera R, Ng VG, Bueno H, Tweet MS, Spertus JA, Hayes SN, Lansky A, Krumholz HM. Depression and Perceived Stress After Spontaneous Coronary Artery Dissection and Comparison With Other Acute Myocardial Infarction (the VIRGO Experience). The American Journal Of Cardiology 2022, 173: 33-38. PMID: 35365290, PMCID: PMC9133198, DOI: 10.1016/j.amjcard.2022.03.005.Peer-Reviewed Original ResearchConceptsSpontaneous coronary artery dissectionPatient Health Questionnaire-9Coronary artery dissectionPSS-14 scoreArtery dissectionBaseline PHQ-9 scoreAcute myocardial infarction patientsCardiovascular risk factorsPHQ-9 scoresAcute myocardial infarctionMyocardial infarction patientsYears of agePerceived Stress Scale scoresStress Scale scoresLinear mixed-effects analysisSCAD casesVIRGO StudyQuestionnaire-9Infarction patientsMixed-effects analysisMyocardial infarctionSubgroup analysisRisk factorsRoutine screeningClinical acuity
2015
Effect of Ischemia Duration and Door-to-Balloon Time on Myocardial Perfusion in ST-Segment Elevation Myocardial Infarction An Analysis From HORIZONS-AMI Trial (Harmonizing Outcomes with Revascularization and Stents in Acute Myocardial Infarction)
Prasad A, Gersh BJ, Mehran R, Brodie BR, Brener SJ, Dizon JM, Lansky AJ, Witzenbichler B, Kornowski R, Guagliumi G, Dudek D, Stone GW. Effect of Ischemia Duration and Door-to-Balloon Time on Myocardial Perfusion in ST-Segment Elevation Myocardial Infarction An Analysis From HORIZONS-AMI Trial (Harmonizing Outcomes with Revascularization and Stents in Acute Myocardial Infarction). JACC Cardiovascular Interventions 2015, 8: 1966-1974. PMID: 26738667, DOI: 10.1016/j.jcin.2015.08.031.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overCoronary CirculationDrug-Eluting StentsFemaleHumansMaleMetalsMicrocirculationMiddle AgedMyocardial InfarctionMyocardial Perfusion ImagingPercutaneous Coronary InterventionProspective StudiesProsthesis DesignRisk AssessmentRisk FactorsStentsTime FactorsTime-to-TreatmentTreatment OutcomeConceptsPrimary percutaneous coronary interventionMyocardial blush gradePrimary PCIHORIZONS-AMI trialMBG 0/1Balloon timeIndependent predictorsAnterior infarctionMyocardial perfusionST-segment elevation myocardial infarction (STEMI) patientsST-segment elevation myocardial infarctionHigher clinical risk profileElevation myocardial infarction patientsMyocardial Infarction (TIMI) risk scoreClinical risk profileMechanical reperfusion therapyReference vessel diameterElevation myocardial infarctionPercutaneous coronary interventionST-segment elevationEpicardial blood flowMinimum lumen diameterMyocardial infarction patientsMicrovascular reperfusionBlush gradeMorphological changes and clinical impact of unstable plaques within untreated segments of acute myocardial infarction patients during a 3-year follow-up
Souza CF, Doi H, Mintz GS, Lansky AJ, Witzenbichler B, Guagliumi G, Brodie BR, Kellett MA, Xu K, Mehran R, Stone GW, Maehara A. Morphological changes and clinical impact of unstable plaques within untreated segments of acute myocardial infarction patients during a 3-year follow-up. Coronary Artery Disease 2015, 26: 469-475. PMID: 25919902, DOI: 10.1097/mca.0000000000000251.Peer-Reviewed Original ResearchMeSH KeywordsAgedCoronary Artery DiseaseCoronary VesselsFemaleHumansMaleMiddle AgedMyocardial InfarctionPercutaneous Coronary InterventionPlaque, AtheroscleroticPlatelet Aggregation InhibitorsPredictive Value of TestsProspective StudiesRisk FactorsRupture, SpontaneousStentsTime FactorsTreatment OutcomeUltrasonography, InterventionalWound HealingConceptsST-segment elevation myocardial infarctionPlaque ruptureIntravascular ultrasoundClinical eventsUnstable plaquesLumen compromiseUntreated segmentsAcute Myocardial Infarction trialLong-term clinical outcomesAcute myocardial infarction patientsBaseline intravascular ultrasoundOptimal systemic therapySerial IVUS analysisMyocardial Infarction trialElevation myocardial infarctionInfarct-related arteryMyocardial infarction patientsThree-year followAttenuated plaqueHarmonizing OutcomesNonculprit lesionsSTEMI patientsSystemic therapyClinical outcomesInfarction patients
2014
Impact of Nonculprit Vessel Myocardial Perfusion on Outcomes of Patients Undergoing Percutaneous Coronary Intervention for Acute Coronary Syndromes Analysis From the ACUITY Trial (Acute Catheterization and Urgent Intervention Triage Strategy)
Lansky AJ, Ng VG, Meller S, Xu K, Fahy M, Feit F, Ohman EM, White HD, Mehran R, Bertrand ME, Desmet W, Hamon M, Stone GW. Impact of Nonculprit Vessel Myocardial Perfusion on Outcomes of Patients Undergoing Percutaneous Coronary Intervention for Acute Coronary Syndromes Analysis From the ACUITY Trial (Acute Catheterization and Urgent Intervention Triage Strategy). JACC Cardiovascular Interventions 2014, 7: 266-275. PMID: 24650400, DOI: 10.1016/j.jcin.2013.08.016.Peer-Reviewed Original ResearchMeSH KeywordsAcute Coronary SyndromeAgedCardiac CatheterizationCoronary AngiographyCoronary CirculationDouble-Blind MethodElectrocardiographyEmergenciesFemaleFollow-Up StudiesHumansMaleMiddle AgedMyocardial Perfusion ImagingPercutaneous Coronary InterventionPericardiumPractice Guidelines as TopicPrognosisProspective StudiesSurvival RateTriageUnited StatesConceptsPercutaneous coronary interventionMyocardial blush gradeNSTE-ACS patientsMBG 0/1Myocardial perfusionACUITY trialNonculprit vesselsCulprit vesselCoronary interventionSegment elevation acute coronary syndrome patientsST-segment elevation myocardial infarction (STEMI) patientsElevation acute coronary syndrome patientsOutcomes of PCIAcute Coronary Syndromes AnalysisTIMI flow grade 3Worse baseline clinical characteristicsAcute coronary syndrome patientsElevation myocardial infarction patientsLong-term mortality ratesInfarct-related vesselBaseline clinical characteristicsOutcomes of patientsCoronary syndrome patientsRisk-stratify patientsMyocardial infarction patients
2011
Effect of Switching Antithrombin Agents for Primary Angioplasty in Acute Myocardial Infarction The HORIZONS-SWITCH Analysis
Dangas GD, Mehran R, Nikolsky E, Claessen BE, Lansky AJ, Brodie BR, Witzenbichler B, Guagliumi G, Peruga JZ, Dudek D, Möckel M, Caixeta A, Parise H, White H, Stone GW, Investigators H. Effect of Switching Antithrombin Agents for Primary Angioplasty in Acute Myocardial Infarction The HORIZONS-SWITCH Analysis. Journal Of The American College Of Cardiology 2011, 57: 2309-2316. PMID: 21636031, DOI: 10.1016/j.jacc.2011.01.038.Peer-Reviewed Original ResearchConceptsST-segment elevation myocardial infarctionElevation myocardial infarctionMajor bleedingMyocardial infarctionCardiac mortalityAcute ST-segment elevation myocardial infarctionST-segment elevation myocardial infarction (STEMI) patientsPrimary Percutaneous Coronary Intervention ResultsGlycoprotein IIb/IIIa inhibitorsPercutaneous Coronary Intervention ResultsElevation myocardial infarction patientsPrimary percutaneous coronary interventionIIb/IIIa inhibitorsBenefit of bivalirudinLate cardiac survivalProbable stent thrombosisPercutaneous coronary interventionTwo-year rateAcute myocardial infarctionMyocardial infarction patientsHORIZONS-AMISwitch patientsPrimary angioplastyControl patientsCoronary interventionIMPACT OF CHRONIC KIDNEY DISEASE ON LONG-TERM OUTCOMES IN ST-ELEVATION MYOCARDIAL INFARCTION PATIENTS TREATED WITH PRIMARY PERCUTANEOUS CORONARY INTERVENTION AND ALTERNATIVE ANTITHROMBOTIC TREATMENT STRATEGIES: A HORIZONS-AMI SUBSTUDY
Saltzman A, Claessen B, Narula A, Weisz G, Brodie B, Witzenbichler B, Guagliumi G, Kornowski R, Dudek D, Lansky A, Nikolsky E, Dangas G, Stone G, Mehran R. IMPACT OF CHRONIC KIDNEY DISEASE ON LONG-TERM OUTCOMES IN ST-ELEVATION MYOCARDIAL INFARCTION PATIENTS TREATED WITH PRIMARY PERCUTANEOUS CORONARY INTERVENTION AND ALTERNATIVE ANTITHROMBOTIC TREATMENT STRATEGIES: A HORIZONS-AMI SUBSTUDY. Journal Of The American College Of Cardiology 2011, 57: e904. DOI: 10.1016/s0735-1097(11)60904-2.Peer-Reviewed Original Research
2010
Incidence, Mechanisms, Predictors, and Clinical Impact of Acute and Late Stent Malapposition After Primary Intervention in Patients With Acute Myocardial Infarction
Guo N, Maehara A, Mintz GS, He Y, Xu K, Wu X, Lansky AJ, Witzenbichler B, Guagliumi G, Brodie B, Kellett MA, Dressler O, Parise H, Mehran R, Stone GW. Incidence, Mechanisms, Predictors, and Clinical Impact of Acute and Late Stent Malapposition After Primary Intervention in Patients With Acute Myocardial Infarction. Circulation 2010, 122: 1077-1084. PMID: 20805433, DOI: 10.1161/circulationaha.109.906040.Peer-Reviewed Original ResearchConceptsAcute stent malappositionPaclitaxel-eluting stentsBare metal stentsLate stent malappositionPES-treated lesionsStent malappositionPositive remodelingMyocardial infarctionST-segment elevation myocardial infarction (STEMI) patientsST-segment elevation myocardial infarctionEquivalent bare metal stentsAcute Myocardial Infarction trialElevation myocardial infarction patientsASM areaExternal elastic membrane areaIntravascular ultrasound substudyPeri-stent plaquePrimary stent implantationMyocardial Infarction trialNative coronary lesionsElevation myocardial infarctionAcute myocardial infarctionMyocardial infarction patientsSubset of lesionsExternal elastic membrane